The Link Between Periodontal Disease and Systemic Diseases: State of the Evidence 2005

Hamilton, Janyce

doi:10.1080/19424396.2005.12223841

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…Increasing researches showed the key associations between oral health and systemic diseases. Periodontitis can increase abnormalities in diabetes, cardiovascular, respiratory, digestive, endocrine, musculoskeletal and reproductive systems (John et al, 2016). Moreover, many studies have shown that periodontitis can aggravate the progression of liver cancer (Al‐Maweri et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Porphyromonas gingivalis triggers inflammation in hepatocyte depend on ferroptosis via activating the NF‐κB signaling pathway

Yao

Lan

et al. 2023

Oral Diseases

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ObjectiveNon‐alcoholic fatty liver disease (NAFLD) is a clinicopathological syndrome characterized by excessive fat deposition in hepatocytes caused by non‐alcoholic liver injury. Porphyromonas gingivalis (P.g) is the main pathogen causing periodontitis, which can aggravate the progression of NAFLD in our previously study. The objective of this study was to further investigate the pathogenesis and moleculer michanisma of NAFLD aggravated by P.g.MethodsA mouse model of NAFLD was established, and the changes of inflammatory factors and NF‐κB signaling pathway in liver tissue and L‐02 cells were analyzed by transcriptome sequencing, Western blot, IHC and RT‐PCR. In addition, the NF‐κB signaling pathway inhibitor QNZ and ferroptosis inhibitor Fer‐1 were used to analyze the relationship between NF‐κB signaling pathway and ferroptosis in vitro.ResultsIn vivo and in vitro experiments, P.g can induce liver inflammation and activate NF‐κB signaling pathway. At the same time, P.g promotes ferroptosis and inflammation in L‐02 in vitro. QNZ alleviates ferroptosis and inflammatory activation in L‐02. Fer‐1 can relieve the L‐02 inflammation caused by P.g products.ConclusionPorphyromonas gingivalis can induce ferroptosis and inflammation in hepatocytes and further worsen liver lesions. The mechanism of ferroptosis in hepatocytes depends on NF‐κB signaling pathway, which provides a new strategy for clinical treatment and prevention of NAFLD.

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Section: Introductionmentioning

confidence: 99%

“…cardiovascular, respiratory, digestive, endocrine, musculoskeletal and reproductive systems (John et al, 2016). Moreover, many studies have shown that periodontitis can aggravate the progression of liver cancer (Al-Maweri et al, 2021).…”

mentioning

confidence: 99%