The Link Between Obstructive Sleep Apnea and Cardiovascular Disease

Bauters, F; Rietzschel, Ernst; Hertegonne, Katrien; Chirinos, Julio A.

doi:10.1007/s11883-015-0556-z

Cited by 124 publications

(78 citation statements)

References 97 publications

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“…Third, disrupted sleep increases sympathetic nervous activity, leading to an increase in blood pressure and heart rate, which demands cardiac activity at a time when the heart should be regenerating 2, 19, 20. In addition, several studies have shown that SA is associated with hypertension, coronary artery disease, arrhythmias, obesity, diabetes mellitus, and metabolic disturbances, all known to increase the risk of HF 2, 3, 21, 22. Hence, we applied many of these comorbidities in our regression models, including continuous assessment of their presence.…”

Section: Discussionmentioning

confidence: 99%

Sleep Apnea, the Risk of Developing Heart Failure, and Potential Benefits of Continuous Positive Airway Pressure (CPAP) Therapy

Holt

Bjerre

Zareini

et al. 2018

JAHA

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BackgroundWhether there is an association between sleep apnea (SA) and the risk of developing heart failure (HF) is unclear. Furthermore, it has never been established whether continuous positive airway pressure (CPAP) therapy can prevent development of HF. We aimed to investigate SA patients’ risk of developing HF and the association of CPAP therapy.Methods and ResultsUsing nationwide databases, the entire Danish population was followed from 2000 until 2012. patients with SA receiving and not receiving CPAP therapy were identified and compared with the background population. The primary end point was first‐time hospital contact for HF and adjusted incidence rate ratios of HF were calculated using Poisson regression models. Among 4.9 million individuals included, 40 485 developed SA during the study period (median age: 53.4 years, 78.5% men) of whom 45.2% received CPAP therapy. Crude rates of HF were increased in all patients with SA relative to the background population. In the adjusted model, the incidence rate ratios of HF were increased in the untreated SA patients of all ages, compared with the background population. Comparing the CPAP‐treated patients with SA with the untreated patients with SA showed significantly lower incidence rate ratios of HF among older patients.ConclusionsIn this nationwide cohort study, SA not treated with CPAP was associated with an increased risk of HF in patients of all ages. Use of CPAP therapy was associated with a lower risk of incident HF in patients >60 years of age, suggesting a protective effect of CPAP therapy in the elderly.

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Section: Discussionmentioning

confidence: 99%

Sleep Apnea, the Risk of Developing Heart Failure, and Potential Benefits of Continuous Positive Airway Pressure (CPAP) Therapy

Holt

Bjerre

Zareini

et al. 2018

JAHA

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“…The results of this paper, apparently showing that CPAP had no protective effect against various forms of cardiovascular disease (CVD), came as a surprise to us in light of the accumulated evidence linking OSA with CVD. The currently available data from randomized controlled trials (RCTs) have shown that CPAP has beneficial effects on factors associated with CVD such as blood pressure, increased sympathetic activity, endothelial function, and insulin sensitivity [2,3]. In addition, several observational studies have shown that CPAP use reduces the risk of cardiovascular events due to OSA and cardiovascular related death [2,3].…”

Section: A Paper By Mcevoy Et Al Recently Appeared In the Newmentioning

confidence: 99%

The SAVE Trial: Has the Importance of CPAP for Preventing Cardiovascular Events been Discounted?

BaHammam

Pandi-Perumal²,

Spence³

et al. 2017

Sleep Vigilance

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“…The current gold standard treatment for OSAS is CPAP therapy, which has been demonstrated not only to significantly improve sleep quality, reduce the risk of comorbidities and increase patient quality of life, but also to minimize risks of accidents and injuries[71-74]. By effectively diminishing the intermittent hypoxia episodes, CPAP can prevent the activation of pathogenic mechanism that has been shown to affect EPCs number and function.…”

Section: Circulating Stem/progenitor Cellsmentioning

confidence: 99%

Stem/progenitor cells and obstructive sleep apnea syndrome - new insights for clinical applications

Micheu

Rosca

Deleanu

2016

WJSC

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Obstructive sleep apnea syndrome (OSAS) is a widespread disorder, characterized by recurrent upper airway obstruction during sleep, mostly as a result of complete or partial pharyngeal obstruction. Due to the occurrence of frequent and regular hypoxic events, patients with OSAS are at increased risk of cardiovascular disease, stroke, metabolic disorders, occupational errors, motor vehicle accidents and even death. Thus, OSAS has severe consequences and represents a significant economic burden. However, some of the consequences, as well as their costs can be reduced with appropriate detection and treatment. In this context, the recent advances that were made in stem cell biology knowledge and stem cell - based technologies hold a great promise for various medical conditions, including respiratory diseases. However, the investigation of the role of stem cells in OSAS is still recent and rather limited, requiring further studies, both in animal models and humans. The goal of this review is to summarize the current state of knowledge regarding both lung resident as well as circulating stem/progenitor cells and discuss existing controversies in the field in order to identify future research directions for clinical applications in OSAS. Also, the paper highlights the requisite for inter-institutional, multi-disciplinary research collaborations in order to achieve breakthrough results in the field.

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The Link Between Obstructive Sleep Apnea and Cardiovascular Disease

Cited by 124 publications

References 97 publications

Sleep Apnea, the Risk of Developing Heart Failure, and Potential Benefits of Continuous Positive Airway Pressure (CPAP) Therapy

Sleep Apnea, the Risk of Developing Heart Failure, and Potential Benefits of Continuous Positive Airway Pressure (CPAP) Therapy

The SAVE Trial: Has the Importance of CPAP for Preventing Cardiovascular Events been Discounted?

Stem/progenitor cells and obstructive sleep apnea syndrome - new insights for clinical applications

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