The link between nutritional status and outcomes in COVID-19 patients in ICU: Is obesity or sarcopenia the real problem?

Molfino, Alessio; Imbimbo, Giovanni; Rizzo, Veronica; Alampi, Daniela

doi:10.1016/j.ejim.2021.06.028

Cited by 13 publications

(16 citation statements)

References 10 publications

(17 reference statements)

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“…Moreover, the data by Qaisar et al. [3] are of interest, indicating that individuals with sarcopenia at baseline or after the COVID-19 infection showed worse disease severity scores than those without sarcopenia, extending our findings [1] .…”

supporting

confidence: 87%

mentioning

confidence: 99%

“…We are glad of the high interest received regarding our original data on the level of muscularity, comorbidities and outcomes among critically ill COVID-19 patients [1] , [2] , [3] . In particular, of note was that the prevalence of comorbidities in our cohort was approximately 2-times more common in those patients who died [1] and that the non-survivors were older than survivors, suggesting the importance also of aging in the development of sarcopenia [ 1 , 2 ]. In this light, we agree with the observation [2] that the presence of comorbidities (including obesity) - associated with aging - might have promoted the development of sarcopenia and in turn mortality in our cohort of patients.…”

mentioning

confidence: 99%

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The relevance of nutritional and metabolic derangements in COVID-19 patients

Molfino

Imbimbo

2022

European Journal of Internal Medicine

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confidence: 87%

mentioning

confidence: 99%

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confidence: 99%

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The relevance of nutritional and metabolic derangements in COVID-19 patients

Molfino

Imbimbo

2022

European Journal of Internal Medicine

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“…Obesity is a risk factor for limited mobility and reduced physical activity. The study conducted by Molfino et al on a group of 25 patients with an average age of 67 years (2004) supports the idea that the risk of disability is increased when obesity and sarcopenia are associated [29,30]. The same study supports a decrease in muscle strength in sarcopenic obese patients.…”

Section: Discussionmentioning

confidence: 72%

The Effects of the ‘Catabolic Crisis’ on Patients’ Prolonged Immobility after COVID-19 Infection

et al. 2022

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Background and Objectives: Quarantine, isolation and bed rest associated with COVID-19 infection favored the loss of muscle and bone mass, especially in elderly patients. The current study aims to compare the presence of sarcopenia and osteoporosis in patients with a recent (one month) history of SARS-CoV-2 infection versus the general population. Materials and Methods: A cross-sectional study was conducted in which 157 patients were enrolled, divided into two groups, comparable in structure. The COVID-19 group (group C) consisted of 86 patients who were diagnosed with SARS-CoV-2 respiratory infection within the last 30 days. The non-COVID-19 group (group NC) consists of 71 patients who had no clinical signs of respiratory infection and were not quarantined/hospitalized in the last 3 months. Muscle strength, incidence of sarcopenia (using SARC-F score) and osteoporosis (DEXA determination) and physical performance (SPPB score) in the two groups were assessed and compared. Results: No statistically significant differences were found between the SPPB scores of the C group versus the NC group. Statistically significant differences were found in the evaluation of three parameters included in the SARC-F score. Patients in the C group had difficulties in standing up from a chair (p = 0.009) and climbing stairs (p = 0.030) due to lower muscle strength (p = 0.002) compared with patients in the NC group. No correlation of the SARC F and SPPB scores with the T score values obtained by osteo-densitometry was found. Conclusions: The sudden and significant reduction in physical activity, through various measures taken in the general population during the pandemic, led to an increased incidence of sarcopenia, both in patients who did not have COVID-19 infection and among those quarantined/hospitalized for this condition.

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“…Obesity in COVID-19 patients has been shown to be frequent and to worsen the disease prognosis (110). Unfortunately, especially in the ICU cases, only the BMI has been measured while body composition analysis has been rarely assessed (111).…”

Section: Sarcopenic Obesity: Role Of Muscle-fat Crosstalkmentioning

confidence: 99%

Skeletal Muscle in Hypoxia and Inflammation: Insights on the COVID-19 Pandemic

et al. 2022

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SARS-CoV-2 infection is often associated with severe inflammation, oxidative stress, hypoxia and impaired physical activity. These factors all together contribute to muscle wasting and fatigue. In addition, there is evidence of a direct SARS-CoV-2 viral infiltration into skeletal muscle. Aging is often characterized by sarcopenia or sarcopenic obesity These conditions are risk factors for severe acute COVID-19 and long-COVID-19 syndrome. From these observations we may predict a strong association between COVID-19 and decreased muscle mass and functions. While the relationship between physical inactivity, chronic inflammation, oxidative stress and muscle dysfunction is well-known, the effects on muscle mass of COVID-19-related hypoxemia are inadequately investigated. The aim of this review is to highlight metabolic, immunity-related and redox biomarkers potentially affected by reduced oxygen availability and/or muscle fatigue in order to shed light on the negative impact of COVID-19 on muscle mass and function. Possible countermeasures are also reviewed.

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The link between nutritional status and outcomes in COVID-19 patients in ICU: Is obesity or sarcopenia the real problem?

Cited by 13 publications

References 10 publications

The relevance of nutritional and metabolic derangements in COVID-19 patients

The relevance of nutritional and metabolic derangements in COVID-19 patients

The Effects of the ‘Catabolic Crisis’ on Patients’ Prolonged Immobility after COVID-19 Infection

Skeletal Muscle in Hypoxia and Inflammation: Insights on the COVID-19 Pandemic

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