The Link between Cognitive Measures and ADLs and IADL Functioning in Mild Alzheimer′s: What has Gender Got to Do with It?

Hall, James; Vo, Hoa T.; Johnson, Leigh; Barber, Robert C.; O’Bryant, Sid

doi:10.4061/2011/276734

Cited by 76 publications

(79 citation statements)

References 23 publications

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“…There seems to be a stronger relationship between IADL results and cognitive performance than between BADL and cognitive function 22 . As IADL require a more complex neuropsychological organization, such activities are much more vulnerable in the early stages of cognitive decline 4 .…”

Section: Discussionmentioning

confidence: 79%

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Alterações motoras e funcionais em diferentes estágios da doença de Alzheimer

Zidan¹,

Arcoverde²,

Araújo³

et al. 2012

Rev. psiquiatr. clín.

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Background: Alzheimer's disease (AD) is the most prevalent dementia, being associated with cognitive, behavioral, and functional alterations. However, clarifying the influence of the disease worsening in the decline of these functions is of major relevance. Objective: Compare specific cognitive functions, motor functions and activities of daily living (ADL) of AD patients in different stages of the disease. Methods: Cognitive and motor functions, as well as ADL of 74 AD patients (35 patients CDR1; 20 patients CDR2; 19 patients CDR3) were evaluated. Results: Motor function and independency in the ADL have presented a non-linear decline. While motor function shows a greater decline from the mild to the moderate phase, ADL present a greater decline in the severe stage of the disease. Discussion: Motor function decline is more evident in both moderate and severe stages of AD, associated with losses in physical capacity and increases in risk of falls. The patients' loss of independency to perform instrumental ADL occurs in a non-linear pattern and it is much greater than both physical and cognitive declines when these parameters are objectively evaluated in the three phases of the disease.

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Section: Discussionmentioning

confidence: 79%

“…While both BADL and IADL are affected in AD, IADL are the first ones to decline. Basically, functional impairment is the distinction point between AD and mild cognitive impairment 22 .…”

Section: Discussionmentioning

confidence: 99%

Alterações motoras e funcionais em diferentes estágios da doença de Alzheimer

Zidan¹,

Arcoverde²,

Araújo³

et al. 2012

Rev. psiquiatr. clín.

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show abstract

“…34 In daily clinical practice, several MOCA items such as the animal picture naming and repetition sentences appear as a relatively poor discriminator because of a ceiling effect 49 : this could explain our finding of a lower optimal cutoff than the conventional cutoff for an optimal use of the MOCA.…”

Section: Discussionmentioning

confidence: 83%

The Lawton Instrumental Activities Daily Living/Activities Daily Living Scales

Koskas

Henry–Feugeas

Feugeas

et al. 2014

J Geriatr Psychiatry Neurol

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“…Gender differences may have contributed to the divergence of findings among previous research studies in this area. Work from our group and others have found gender differences in depression and cognitive function [7, 57], and gender differences in domain-specific cognitive functioning and ADLs [57]. …”

Section: Discussion/conclusionmentioning

confidence: 99%

Vascular Depression and Cognition in Mexican Americans

Johnson¹,

Large

Munoz

et al. 2019

Dement Geriatr Cogn Disord

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Background: Mexican Americans are at increased risk of developing mild cognitive impairment (MCI) and Alzheimer’s disease compared to non-Hispanic whites. This study sought to examine the relationship between vascular risk, depression, and cognition in Mexican American elders. Methods: Data from 470 (390 normal controls, 80 MCI patients) Mexican Americans enrolled in the Health and Aging Brain among Latino Elders (HABLE) study were used. The cardiovascular risk was assessed by the Framingham Risk Score. Cognition was assessed with a neuropsychological battery, and depression was assessed based on scores from the Geriatric Depression Scale (GDS). ANOVAs were utilized to determine the differences in neuropsychological scores of normal controls with and without depression and CVD risk (low vs. high). Follow-up logistic regression was conducted to determine MCI risk. Results: The results of this study indicated that comorbid depression and a high CVD risk were associated with poorer cognitive performance in Mexican Americans. Depressed women with high CVD risk were more likely to have executive dysfunction, language deficits, and poorer global cognition than nondepressed women with a high CVD risk. In Mexican American men, those with a high vascular risk and depression were more likely to have executive dysfunction and poorer immediate memory than the nondepressed high-risk group. Higher GDS scores (OR = 1.10; 95% CI 1.02–1.10, p = 0.001) and higher vascular risk scores (OR = 1.05; 95% CI 1.02–1.10, p = 0.001) significantly predicted MCI status in Mexican Americans. Conclusion: The results of this study indicated that comorbid depression and a high CVD risk were associated with poorer cognitive performance and increased risk of MCI in Mexican Americans.

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The Link between Cognitive Measures and ADLs and IADL Functioning in Mild Alzheimer′s: What has Gender Got to Do with It?

Cited by 76 publications

References 23 publications

Alterações motoras e funcionais em diferentes estágios da doença de Alzheimer

Alterações motoras e funcionais em diferentes estágios da doença de Alzheimer

The Lawton Instrumental Activities Daily Living/Activities Daily Living Scales

Vascular Depression and Cognition in Mexican Americans

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