The Link between Ankylosing Spondylitis, Crohn’s Disease,<i>Klebsiella</i>, and Starch Consumption

Rashid, Taha; Wilson, Clyde; Ebringer, Alan

doi:10.1155/2013/872632

Cited by 57 publications

(51 citation statements)

References 74 publications

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“…Since these tests have high sensitivity and specificity, they could be used for AS patients by clinicians. AS and IBD may accompany each other, which means a fecal calprotectin test in AS patients may be used in the early diagnosis of IBD and in patient monetarization [18]. Our study has some limitations.…”

Section: Discussionmentioning

confidence: 90%

Fecal calprotectin is associated with disease activity in patients with ankylosing spondylitis

Duran

Kobak

Şen

et al. 2016

Bosn J of Basic Med Sci

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Calprotectin is one of the major antimicrobial S100 leucocyte proteins. Serum calprotectin levels are associated with certain inflammatory diseases such as rheumatoid arthritis, systemic lupus erythematosus and inflammatory bowel disease. The aim of this study was to investigate serum and fecal calprotectin levels in patients with ankylosing spondylitis (AS) and show their potential relations to the clinical findings of the disease. Fifty-one patients fulfilling the New York criteria of AS and 43 healthy age-and gender-matched volunteers were included in the study. Physical and locomotor system examinations were performed and history data were obtained for all patients. Disease activity parameters were assessed together with anthropometric parameters. Routine laboratory examinations and genetic testing (HLA-B27) were performed. Serum calprotectin levels and fecal calprotectin levels were measured by an enzyme-linked immunosorbent assay. The mean age of the patients was 41.5 years, the mean duration of the disease was 8.6 years, and the delay in diagnosis was 4.2 years. Serum calprotectin levels were similar in both AS patients and in the control group (p=0.233). Serum calprotectin level was correlated with Bath AS disease activity index (BASDAI) and Bath AS functional index (BASFI) (p=0.001, p=0.002, respectively). A higher level of fecal calprotectin was detected in AS patients when compared with the control group. A statistically significant correlation between fecal calprotectin level and BASDAI, BASFI, C-reactive protein and Erythrocyte sedimentation rate were detected (p=0.002, p=0.005, p=0.001, p=0.002, respectively). The results indicated that fecal calprotectin levels were associated with AS disease findings and activity parameters. Calprotectin is a vital disease activity biomarker for AS and may have an important role in the pathogenesis of the disease. Multi-centered prospective studies are needed in order to provide further insight.

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Section: Discussionmentioning

confidence: 90%

Fecal calprotectin is associated with disease activity in patients with ankylosing spondylitis

Duran

Kobak

Şen

et al. 2016

Bosn J of Basic Med Sci

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“…K. pneumoniae has also been identified as a causative agent of other less common, yet serious, infections such as liver abscess and invasive syndrome (39, 40), septic arthritis (41), or generalized pustulosis (42), and as the triggering factor in the initiation and development of ankylosing spondylitis and Crohn's disease (43-45). K. pneumoniae strains have accumulated plasmids that carry virulence and resistance genes that keep increasing its ability to resist the main antibiotics used for treatment such as cephalosporins, carbapenems, penicillins, aminoglycosides or fluoroquinolones (26, 37, 38, 46, 47).…”

mentioning

confidence: 99%

Plasmid-Mediated Antibiotic Resistance and Virulence in Gram-Negatives: the Klebsiella pneumoniae Paradigm

et al. 2014

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Summary Plasmids harbor genes coding for specific functions including virulence factors and antibiotic resistance that permit bacteria to survive the hostile environment found in the host and resist treatment. Together with other genetic elements such as integrons and transposons, and using a variety of mechanisms, plasmids participate in the dissemination of these traits resulting in the virtual elimination of barriers among different kinds of bacteria. In this article we review the current information about physiology and role in virulence and antibiotic resistance of plasmids from the gram-negative opportunistic pathogen Klebsiella pneumoniae. This bacterium has acquired multidrug resistance and is the causative agent of serious communityand hospital-acquired infections. It is also included in the recently defined ESKAPE group of bacteria that cause most of US hospital infections.

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“…(32) food supplements in the past 2 weeks of use the most common were omega-3 (13), multivitamin and/or multimineral (12) …”

Section: Resultsmentioning

confidence: 99%

“…It has been suggested that a low starch diet leads to lower AS disease activity and that Klebsiella pneumoniae, which can be influenced by starch consumption, is a triggering factor involved in the initiation and development of AS (10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Relationship between diet and ankylosing spondylitis: A systematic review

Macfarlane¹,

Abbood²,

Pathan³

et al. 2018

Eur J Rheumatol

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The question of whether diet plays a role in the onset of ankylosing spondylitis (AS) or can affect the course of the disease is an important one for many patients and healthcare providers. The aims of this study were to investigate whether: 1) patients with AS report different diets to those without AS; 2) amongst patients with AS, diet is related to severity; 3) persons with particular diets are less likely to develop AS; 4) specific dietary interventions improve the AS symptoms. The review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Medline, Embase, Cochrane Library, and reference lists of relevant articles were searched. Two authors independently selected eligible studies, assessed the quality of included trials, and extracted the data. Sixteen studies (nine observational and seven interventions) were included in the review. Due to the heterogeneity of the study designs and analyses, the results could not be aggregated. Evidence on a possible relationship between AS and diet is extremely limited and inconclusive due to the majority of included studies being small, single studies with moderate-to-high risk of bias, and insufficient reporting of results.

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The Link between Ankylosing Spondylitis, Crohn’s Disease,Klebsiella, and Starch Consumption

Cited by 57 publications

References 74 publications

Fecal calprotectin is associated with disease activity in patients with ankylosing spondylitis

Fecal calprotectin is associated with disease activity in patients with ankylosing spondylitis

Plasmid-Mediated Antibiotic Resistance and Virulence in Gram-Negatives: the Klebsiella pneumoniae Paradigm

Relationship between diet and ankylosing spondylitis: A systematic review

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