2012
DOI: 10.1016/j.bone.2012.08.040
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The LIM-only protein FHL2 controls mesenchymal cell osteogenic differentiation and bone formation through Wnt5a and Wnt10b

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Cited by 7 publications
(7 citation statements)
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“…Fhl2 can interact with β‐catenin, potentiating β‐catenin nuclear translocation and TCF/LEF transcription [Hamidouche et al, ]. Fhl2 can also be activated by Wnt3a at a transcriptional level [Brun et al, ], resulting in osteogenesis of bone marrow mesenchymal stem cells. Since Fhl2 acts similarly to Fhl1 during osteogenesis, they may functionally compensate each other because of evolutionary conservation.…”
Section: Discussionmentioning
confidence: 99%
“…Fhl2 can interact with β‐catenin, potentiating β‐catenin nuclear translocation and TCF/LEF transcription [Hamidouche et al, ]. Fhl2 can also be activated by Wnt3a at a transcriptional level [Brun et al, ], resulting in osteogenesis of bone marrow mesenchymal stem cells. Since Fhl2 acts similarly to Fhl1 during osteogenesis, they may functionally compensate each other because of evolutionary conservation.…”
Section: Discussionmentioning
confidence: 99%
“…Because both effects were blocked by conditional disruption of Igf1 in osteocytes, it would suggest that osteocyte-derived IGF-I is important for the endosteal lamellar bone formation as well as for the periosteal woven bone formation. There is strong evidence that the periosteal woven bone formation in response to mechanical loading is mediated through the commitment of mesenchymal stem cells into osteoblast lineage cells primarily by the Wnt signaling (4,5). The mechanism by which loading enhances endosteal lamellar bone formation has not been determined, but it is likely mediated through stimulation of cell proliferation and activity of existing osteoblasts by yet-to-beidentified signaling pathways.…”
Section: E277mentioning
confidence: 99%
“…FHL2 is a serum-inducible coactivator of the transcription factor AP1 (7), the downstream effector of receptor tyrosine kinase-initiated signaling cascades. In Wnt/␤-catenin signaling, FHL2 exerts both transcription corepressor and coactivator functions of ␤-catenin, depending on the cellular context (8)(9)(10)(11). The main receptor of Sonic hedgehog Patched recruits a proapoptotic complex containing FHL2 and caspase 9 and triggers cell death through a caspase 9-dependent mechanism (12).…”
mentioning
confidence: 99%