The Lignans

Albertson, Anna K. F.; Lumb, Jean‐Philip

doi:10.1002/9781119427896.ch1

Cited by 3 publications

(2 citation statements)

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“…The biosynthesis of lignans starts from a regio- and stereoselective, oxidative coupling of two coniferyl alcohol or their biogenetic equivalents (propenyl phenols), to form a large variety of distinct molecules [ 6 , 7 ]. On the base of their chemical structure, they are divided into several classes.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Aryltetralin Lignans Production in Linum Adventi-Tious Root Cultures

et al. 2021

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Lignans are the main secondary metabolites synthetized by Linum species as plant defense molecules. They are also valuable for human health, in particular, for their potent antiviral and antineoplastic properties. In this study, the adventitious root cultures of three Linum species (L. flavum, L. mucronatum and L. dolomiticum) were developed to produce aryltetralin lignans. The effect of two elicitors, methyl jasmonate and coronatine, on aryltetralin lignans production was also evaluated. The adventitious root cultures from L. dolomiticum were obtained and analyzed for the first time and resulted as the best producer for all the aryltetralins highlighted in this system: Podophyllotoxin, 6-methoxypodophyllotoxin and 6-methoxypodophyllotoxin-7-O-β-glucoside, the last showing a productivity of 92.6 mg/g DW. The two elicitors differently affected the production of the 6-methoxypodophyllotoxin and 6-methoxypodophyllotoxin-7-O-β-glucoside.

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Section: Introductionmentioning

confidence: 99%

Enhanced Aryltetralin Lignans Production in Linum Adventi-Tious Root Cultures

et al. 2021

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“…The classical lignans are phenylpropane dimers linked in a β–β′(8–8′) fashion biosynthesized from synapyl alcohol. In contrast, various dimeric pattern in the relative less common neolignans rendered them as challenging synthetic targets . Recently, codonopiloneolignanin A, a polycyclic neolignan was isolated by Shi from the roots of Codonopsispilosula (Franch), named “dang shen” in Chinese, which is one of the most common drugs in traditional Chinese medicine .…”

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confidence: 99%