The life‐history of the formed elements of the blood, especially the red blood corpuscles

Howell, W. H.

doi:10.1002/jmor.1050040105

Cited by 59 publications

(20 citation statements)

References 8 publications

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“…Micronuclei, initially found in red blood cells by Howell (1891) and described by Jolly (1905), are small DNA-containing bodies which can be present near the cell nucleus during interphase as a consequence of both chromosome breakage and spindle disfunction. 'Micronucleus tests' to evaluate chromoson~al damage were performed in the early 1970's by Bo!…”

Section: Introductionmentioning

confidence: 99%

The micronucleus test: examples of application to marine ecology

Brunetti¹,

Majone²,

Gola³

et al. 1988

Mar. Ecol. Prog. Ser.

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Section: Introductionmentioning

confidence: 99%

The micronucleus test: examples of application to marine ecology

Brunetti¹,

Majone²,

Gola³

et al. 1988

Mar. Ecol. Prog. Ser.

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“…Havers (1691) recognised that marrow is redder in certain sites and noted that these areas have more blood vessels. The haemopoietic function of bone marrow was only understood after the discovery of nucleated red cells in this tissue by Neumann and Bizzozero independently in 1868 (Howell, 1890). Hunter was, however, correct in his view that the yellow marrow is a fat store.…”

Section: Hunter Said ''In My Opinion the Reason Of Epiphyses Is Not mentioning

confidence: 99%

What did William Hunter know about bone?

McDonald

Russell

2005

Clinical Anatomy

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This article examines William Hunter's specimens on bone in the Anatomy Museum at the University of Glasgow. By referring to students' notes taken at Hunter's lectures and to the Manuscript Catalogue of his anatomical specimens, we attempt to answer the question, ''What did William Hunter know about bone?'' Hunter seems to have been particularly interested in the relationship between vascularisation and ossification and many of the specimens illustrate this. He provided his students with reasoned arguments on a number of issues: that the marrow serves as a fat store and not to produce synovial fluid or to keep bones supple; the periosteum serves as an attachment for tendons and ligaments; the rationale for the presence of epiphyses is not readily defined; that bones form by intramembranous and endochondral ossification and that, in the latter, cartilage is replaced by bone. William Hunter narrowly failed to realise that in long bones new bone is laid down by the periosteum and at the epiphysial plates, and is remodeled. These discoveries were to be made by his brother, John. Clin. Anat. 18:155-163, 2005. ' 2005 Wiley-Liss, Inc.

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“…HJBs are inclusion bodies present in erythrocytes that stain with May-Giemsa and are not normally observed in healthy persons, although they are seen in some patients with blood disorders or functional asplenia and those treated with splenectomy (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Howell-Jolly Bodies Caused by Partial Splenic Embolization for Portal Hypertension

et al. 2013

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Objective Postsplenectomy sepsis (PSS) and overwhelming postsplenectomy infection (OPSI) following splenectomy or the development of hyposplenism are associated with a high mortality rate. The presence of Howell-Jolly bodies (HJBs) in peripheral erythrocytes is attracting attention as a parameter of hyposplenism. To date, whether HJBs appear following partial splenic embolization (PSE) has not been investigated. Therefore, we examined the prevalence of HJBs in patients who have undergone PSE. Methods Whether HJBs were present in 95 patients who underwent PSE between November 2007 and August 2012 was assessed.Results No serious complications occurred due to PSE; however, 17 of the 95 patients (17.89%) exhibited HJBs during the follow-up. The residual spleen volume and splenic infarction rate did not differ significantly compared to those observed in the HJB-negative group. Conclusion With the recent increase in the use of autoanalyzers, the opportunities to perform microscopic examinations have been decreasing. Therefore, the presence of HJBs, which can only be confirmed visually, may be overlooked, and the clinical significance of these bodies tends to be disregarded. However, the presence of HJBs is associated with a risk of PSS and OPSI due to hyposplenism. Because HJBs are common in the peripheral erythrocytes of patients who have undergone PSE, irrespective of the residual spleen volume or splenic infarction rate, the presence or absence of HJBs should be assessed visually. In HJB-positive patients, preventing serious infections, for example, by administering the pneumococcal vaccine, is important.

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The life‐history of the formed elements of the blood, especially the red blood corpuscles

Cited by 59 publications

References 8 publications

The micronucleus test: examples of application to marine ecology

The micronucleus test: examples of application to marine ecology

What did William Hunter know about bone?

Prevalence of Howell-Jolly Bodies Caused by Partial Splenic Embolization for Portal Hypertension

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