The life cycle of Trypanosoma cruzi revisited

Engman, David M.

doi:10.1016/s0020-7519(01)00153-9

Cited by 347 publications

(294 citation statements)

References 40 publications

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“…Tyler and Engman (2000) have shown that the depletion of glucose from the medium triggers elongation of the epimastigotes flagellum. Later, the authors proposed that the intracellular glucose concentration is the key factor for both elongation of the flagellum and sustaining the differentiation of the metacyclic trypomastigote (Tyler & Engman 2001). In agreement with these data, we observed that the lengthening or shortening process exhibited during the pre-incubation phase is not accompanied by elongation of the metacyclic trypomastigote flagellum.…”

Section: Discussionsupporting

confidence: 91%

“…emphasized that the extreme morphological and motility differences of the trypomastigote and amastigotes stages of T. cruzi offer an excellent chance to study microtubules-based mechanism of morphological control which would be difficult to discern in systems where such change is more subtle (Gull 1999, Tyler & Engman 2001. We have shown by SEM that in axenic conditions the morphological transformation of the tissue-cultured trypomastigotes and the in vitro-induced amastigotes from metacyclic trypomastigotes are different.…”

Section: Discussionmentioning

confidence: 89%

“…In addition, the pHinduced transformation of tissue-derived trypomastigotes is not observed when metacyclic trypomastigotes are incubated under the same conditions (Tyler & Engman 2001). Interestingly, it is known that the first intracellular cycle of metacyclic trypomastigotes is significantly shorter than the cycle of tissue-culture-derived trypomastigotes of the same strain that has been growing as an obligate intracellular parasite for several cycles (Dvorak 1975).…”

Section: Discussionmentioning

confidence: 99%

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Morphological comparison of axenic amastigogenesis of trypomastigotes and metacyclic forms of Trypanosoma cruzi

Navarro

Lima

Askue

et al. 2003

Mem. Inst. Oswaldo Cruz

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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Morphological comparison of axenic amastigogenesis of trypomastigotes and metacyclic forms of Trypanosoma cruzi

Navarro

Lima

Askue

et al. 2003

Mem. Inst. Oswaldo Cruz

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“…The selection of the epimastigote form of T. cruzi as an obligate mammalian intracellular stage has been re-evaluated and confirmed [37][38][39]. The results obtained are shown in table 2.…”

Section: In Vitro Anti-t Cruzi Activitymentioning

confidence: 82%

Novel quinoxaline 1,4-di-N-oxide derivatives as new potential antichagasic agents

Torres

Moreno‐Viguri

Galiano

et al. 2013

European Journal of Medicinal Chemistry

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ABSTRACT. As a continuation of our research and with the aim of obtaining new agents against Chagas disease, an extremely neglected disease which threatens 100 million people, eighteen new quinoxaline 1,4-di-N-oxide derivatives have been synthesized following the Beirut reaction. The synthesis of the new derivatives was optimized through the use of a new and more efficient microwave-assisted organic synthetic method. The new derivatives showed excellent in vitro biological activity against Trypanosoma cruzi. Compound 17, which was substituted with 2 fluoro groups at the 6-and 7-positions of the quinoxaline ring, was the most active and selective in the cytotoxicity assay. The electrochemical study showed that the most active compounds, which were substituted by electron-withdrawing groups, possessed a greater ease of reduction of the N-oxide groups.

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“…Then, they can differentiate into trypomastigotes again, reach circulation and infect new cells. If an uninfected bug feeds from the animal in the moment of parasitemia, cycle starts again (Tyler & Engman, 2001). …”

mentioning

confidence: 99%