The life and work of Jean-Martin Charcot (1825–1893): ‘The Napoleon of Neuroses’

Waraich, Manni; Shah, Shailesh

doi:10.1177/1751143717709420

Cited by 12 publications

(5 citation statements)

References 2 publications

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“…), due in part to Jean‐Martin Charcot (1825–1893), who systematically identified many neurological diseases including Charcot–Marie–Tooth, MS, Parkinson’s disease (PD; only later in 1872 was Parkinson credited for his earlier description, Fig. ) and amyotrophic lateral sclerosis (ALS), by linking the clinical disease in patients with detailed studies of the anatomy and microscopy of diseased tissues . The link between neurology and immunology gained momentum with the refinement of the microscope and development of staining techniques to allow detailed studies of tissue.…”

Section: Historical Beginningsmentioning

confidence: 99%

Neuroimmunology – the past, present and future

Nutma

Willison

Martino

et al. 2019

Clinical and Experimental Immunology

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Summary Neuroimmunology as a separate discipline has its roots in the fields of neurology, neuroscience and immunology. Early studies of the brain by Golgi and Cajal, the detailed clinical and neuropathology studies of Charcot and Thompson’s seminal paper on graft acceptance in the central nervous system, kindled a now rapidly expanding research area, with the aim of understanding pathological mechanisms of inflammatory components of neurological disorders. While neuroimmunologists originally focused on classical neuroinflammatory disorders, such as multiple sclerosis and infections, there is strong evidence to suggest that the immune response contributes to genetic white matter disorders, epilepsy, neurodegenerative diseases, neuropsychiatric disorders, peripheral nervous system and neuro‐oncological conditions, as well as ageing. Technological advances have greatly aided our knowledge of how the immune system influences the nervous system during development and ageing, and how such responses contribute to disease as well as regeneration and repair. Here, we highlight historical aspects and milestones in the field of neuroimmunology and discuss the paradigm shifts that have helped provide novel insights into disease mechanisms. We propose future perspectives including molecular biological studies and experimental models that may have the potential to push many areas of neuroimmunology. Such an understanding of neuroimmunology will open up new avenues for therapeutic approaches to manipulate neuroinflammation.

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Section: Historical Beginningsmentioning

confidence: 99%

Neuroimmunology – the past, present and future

Nutma

Willison

Martino

et al. 2019

Clinical and Experimental Immunology

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“…[5] Charcot, the father of Neurology, believed that he had discovered a new disorder called "hystero-epilepsy," in which female patients "had convulsions, contortions, fainting and impairment of consciousness" (Waraich & Shah 2018).…”

Section: (C)mentioning

confidence: 99%

Mapping the Brain and the Body: The Example of Greek Aesthete Nikolaos Episkopopoulos

Mavroeidi

2022

EJLS

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This article concentrates on the neurological condition of epilepsy in the short story “Mavra” by Greek author Nikolaos Episkopopoulos. An attempt is made to see the condition via the lens of social preconceptions, those who support degeneration, as well as neurological beliefs, through the identification and analysis of the themes that make up the protagonists’ epileptic identities. The reflection of the scientific atmosphere of the 19th century in fin-de-siècle literature is visible through the methodological prism of cognitive literary historicism. The socio-cultural makeup of the epileptic self eventually seems to be captured by the narrator’s body. The narrator’s brain functions are examined using introjection, visual perception, and the most recent finding of mirror neurons, indicating the particular and subjective experience of the illness. Article visualizations:<img src="/-counters-/edu_01/0339/a.php" alt="Hit counter" />

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“…Charcot replaced traditional rounds in the ward with shows, displaying patients with a group of symptoms termed hysteria. During Charcot's time hysteria was very en vogue and he would hence set up a stage for public clinical demonstrations, in which he would interview and hypnotize patients to perform theatrically [1] Various diseases were named after Charcot following his medical achievements. 1 Charcot-Marie-Tooth disease for instance is a neuropathy correlated to a mutation in apoptosis inducing factor mitochondria associated 1 ( AIFM1 ) [ 2 ].…”

Section: Spotlightmentioning

confidence: 99%

Small and mighty – microRNAs pulling the strings

Kattner¹

2022

Biomedical Journal

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The life and work of Jean-Martin Charcot (1825–1893): ‘The Napoleon of Neuroses’

Cited by 12 publications

References 2 publications

Neuroimmunology – the past, present and future

Neuroimmunology – the past, present and future

Mapping the Brain and the Body: The Example of Greek Aesthete Nikolaos Episkopopoulos

Small and mighty – microRNAs pulling the strings

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