The lichen planus-like eruption after bone marrow transplantation

Saurat, Jean‐Hilaire; Gluckman, Éliane; Bussel, A; Didierjean, Liliane; Puissant, A

doi:10.1111/j.1365-2133.1975.tb05118.x

Cited by 108 publications

(28 citation statements)

References 12 publications

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“…Direct immuno fluorescence findings of these eruptions were very similar to those o f 'genuine' LP. There is good evidence that the lichenoid reaction represents a graft-versus-host reaction, in which the target area of the recipient host is likely to be the basal cell compartment of the epithelium [20,21].…”

Section: Discussionmentioning

confidence: 99%

Lymphocytotoxicity for Oral Mucosa in Lichen planus

Simon¹,

Reimer²,

Schardt³

et al. 1983

Dermatology

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The in vitro effect of peripheral blood lymphocytes on syngeneic oral epithelial cells was investigated in 23 patients suffering from lichen planus of skin and/or mucous membranes and in 18 healthy sex- and age-matched volunteers as controls. A modified ⁵¹Cr release macro-assay was used. The result shows a significant lymphocytotoxic effect on the epithelial target cells, giving evidence of cytolytic activities of blood lymphocytes on autologous epithelial cells. We consider these lymphocytes to be involved in the complex pathogenesis of lichen planus.

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Section: Discussionmentioning

confidence: 99%

Lymphocytotoxicity for Oral Mucosa in Lichen planus

Simon¹,

Reimer²,

Schardt³

et al. 1983

Dermatology

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“…40,41 These lesions are erythematous or violaceous papules or plaques, with a squamous surface, sometimes able to form larger confluent areas. The periorbital region, ears, palms, and soles are the typically affected sites (Figure 6).…”

Section: Cutaneous Chronic Gvhdmentioning

confidence: 99%

Cutaneous Graft-versus-Host Disease

Aractingi

Chosidow²

1998

Arch Dermatol

184

177

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“…The histologic diagnosis was made with the use of established criteria. 17,18 Date of diagnosis of cGVHD was determined as the time when an appropriate therapy was started for cGVHD. The modes of presentation were progressive (development from aGVHD without interval), quiescent (development after complete remission from aGVHD), and de novo (without preceding aGVHD) as previously described.…”

Section: Study Definitionsmentioning

confidence: 99%

Development of a prognostic model for grading chronic graft-versus-host disease

Akpek¹,

Zahurak²,

Piantadosi³

et al. 2001

Blood

169

161

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The disease-specific survival (DSS) of 151 patients with chronic graft-versushost disease (cGVHD) was studied in an attempt to stratify patients into risk groups and to form a basis for a new grading of cGVHD. The data included the outcome and 23 variables at the diagnosis of cGVHD and at the primary treatment failure (PTF). Eighty-nine patients (58%) failed primary therapy for cGVHD. Nonrelapse mortality was 44% after a median follow-up of 7.8 years. The probability of DSS at 10 years after diagnosis of cGVHD (DSS1) and after PTF (DSS2) was 51% (95% confidence interval [CI] ‫؍‬ 39%, 60%) and 38% (95% CI ‫؍‬ 28%, 49%), respectively. According to multivariate analysis, extensive skin involvement (ESI) more than 50% of body surface area; hazard ratio (HR) of 7.0 (95% CI ‫؍‬ 3.6-13.4), thrombocytopenia (TP) (< 100 000/L; HR, 3.6; 95% CI ‫؍‬ 1.9-6.8), and progressivetype onset (PTO) (HR, 1.7; 95% CI ‫؍‬ 0.9-3.0) significantly influenced DSS1. These 3 factors and Karnofsky Performance Score of less than 50% at PTF were significant predictors for DSS2. The DSS1 at 10 years for patients with prognostic factor score (PFS) at diagnosis of 0 (none), less than 2 (ESI only or TP and/or PTO), 2 to 3.5 (ESI plus either TP or PTO), and more than 3.5 (all 3 factors) was 82%, 68%, 34%, and 3% (P ‫؍‬ .05, < .001, < .001), respectively. The DSS2 at 5 years for patients with PFS at PTF of 0, 2 or less, 2 to 3.5, and more than 3.5 were 91%, 71%, 22%, and 4% (P ‫؍‬ .2, .005, and < .001), respectively. It was concluded that these prognostic models might be useful in grouping the patients with similar outcome. (Blood. 2001;97:1219-1226)

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The lichen planus-like eruption after bone marrow transplantation

Cited by 108 publications

References 12 publications

Lymphocytotoxicity for Oral Mucosa in Lichen planus

Lymphocytotoxicity for Oral Mucosa in Lichen planus

Cutaneous Graft-versus-Host Disease

Development of a prognostic model for grading chronic graft-versus-host disease

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