The levels of the neutrophil elastase in the amniotic fluid of pregnant women whose infants develop bronchopulmonary dysplasia

Ikeda, Sayako; Kihira, Kana; Yokoi, Akira; Koji, Takehiko; Miyazaki, Ken; Furuhashi, Madoka

doi:10.3109/14767058.2014.921674

Cited by 7 publications

(5 citation statements)

References 27 publications

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“…Of 3170 potentially relevant studies, 158 (5.0%) met the inclusion criteria. The PRISMA flow diagram of the search process is shown in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…Seventy-six studies were designed from the perspective of CA; they examined the outcomes of preterm infants with or without CA, and BPD was one of these outcomes. Sixty-seven studies were designed from the perspective of BPD; they studied risk factors for BPD, and CA was one of these risk factors. Sixteen studies were designed to primarily examine the association between CA and BPD.…”

Section: Resultsmentioning

confidence: 99%

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Association of Chorioamnionitis With Bronchopulmonary Dysplasia Among Preterm Infants

et al. 2019

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Key PointsQuestionIs chorioamnionitis a risk factor for developing bronchopulmonary dysplasia in preterm infants?FindingsThis systematic review, meta-analysis, and metaregression found that chorioamnionitis was associated with an increased risk of bronchopulmonary dysplasia in preterm infants but also found significant differences in baseline characteristics between infants with and infants without chorioamnionitis. A multivariate metaregression model combining the difference in gestational age and the odds of respiratory distress syndrome was associated with 64% of the variance in the association between chorioamnionitis and bronchopulmonary dysplasia.MeaningExposure to chorioamnionitis is associated with a higher risk of developing bronchopulmonary dysplasia in preterm infants, but this association may be modulated by gestational age and risk of respiratory distress syndrome.

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“…Of 3170 potentially relevant studies, 158 (5.0%) met the inclusion criteria. The PRISMA flow diagram of the search process is shown in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Association of Chorioamnionitis With Bronchopulmonary Dysplasia Among Preterm Infants

et al. 2019

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“…Similarly, lower platelet mass has also been associated with BPD, as well as ROP, intraventricular hemorrhage, and necrotizing enterocolitis (403). In contrast, both absolute nucleated red blood cell counts (330) and amniotic fluid levels of neutrophil elastase (226) do not appear to have any utility as biomarkers for BPD in preterm infants. The identification of biomarkers to assess nutritional status of preterm infants has also received attention, where acylcarnitine profiles that reflect fatty acid metabolism have been suggested to reflect nutritional status in preterm infants (186).…”

Section: Biomarkersmentioning

confidence: 99%

Recent advances in our understanding of the mechanisms of late lung development and bronchopulmonary dysplasia

Solaligue

Rodríguez‐Castillo

Ahlbrecht

et al. 2017

American Journal of Physiology-Lung Cellular and Molecular Phys

124

102

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The objective of lung development is to generate an organ of gas exchange that provides both a thin gas diffusion barrier and a large gas diffusion surface area, which concomitantly generates a steep gas diffusion concentration gradient. As such, the lung is perfectly structured to undertake the function of gas exchange: a large number of small alveoli provide extensive surface area within the limited volume of the lung, and a delicate alveolo-capillary barrier brings circulating blood into close proximity to the inspired air. Efficient movement of inspired air and circulating blood through the conducting airways and conducting vessels, respectively, generates steep oxygen and carbon dioxide concentration gradients across the alveolo-capillary barrier, providing ideal conditions for effective diffusion of both gases during breathing. The development of the gas exchange apparatus of the lung occurs during the second phase of lung development-namely, late lung development-which includes the canalicular, saccular, and alveolar stages of lung development. It is during these stages of lung development that preterm-born infants are delivered, when the lung is not yet competent for effective gas exchange. These infants may develop bronchopulmonary dysplasia (BPD), a syndrome complicated by disturbances to the development of the alveoli and the pulmonary vasculature. It is the objective of this review to update the reader about recent developments that further our understanding of the mechanisms of lung alveolarization and vascularization and the pathogenesis of BPD and other neonatal lung diseases that feature lung hypoplasia.

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“…Furthermore, neutrophil elastase may work by correlating inflammation to preterm delivery. 19 , 20 , 22 Elastase is located in polymorphonuclear neutrophils. Furthermore, elastase vitiates collagen cross-links, elastin fibers, and type III collagen, which strengthens the tissues of the cervix.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil Elastase as a Predictor of Delivery in Pregnant Women with Preterm Labour

Eleje,

Nwagha,

Ezebialu

et al. 2023

Explor Res Hypothesis Med

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Background and objectives: No previous study has been conducted in Nigeria on the role of neutrophil elastase in predicting preterm birth. The present study aimed to determine the role of the neutrophil elastase test in predicting birth in women with preterm labor. Methods: The present prospective cohort study recruited 83 pregnant women with preterm labor between 28 and 36 +6 weeks of gestation, and followed up these subjects for 14 days. The controls comprised 85 pregnant women without preterm labor. The cervicovaginal fluid was collected and tested using the neutrophil elastase test. Then, the sensitivity, specificity, and positive and negative predictive parameters were determined. Afterward, the data were scrutinized using the SPSS arithmetic software (Sort23). Results: Among the 168 pregnant women analyzed in the present study, 83 pregnant women were assigned to the preterm labor group, and 85 pregnant women were assigned to the control group. Furthermore, among the 83 pregnant women in the preterm labor group, 11 women had spontaneous preterm delivery, leading to a spontaneous preterm birth proportion of 13.3%. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the neutrophil elastase test within 14 days post-enrollment were 93.8%, 61.2%, 36.6%, 97.6%, and 67.5%, respectively, for the general population, and 87.5%, 66.7%, 35.0%, 96.3%, and 70.2%, respectively, for subjects at <35 weeks of gestation. The positive and negative likelihood ratios for preterm birth prediction were 2.62 and 0.19, respectively. Conclusion: The neutrophil elastase test exhibited high predictive accuracy in pregnant women with preterm labor, when compared to the controls, based on the sensitivity and negative predictive value, but this had poor positive predictive values. The neutrophil elastase test may be used as a screening test, but not as a potential predictive test, in the routine clinical setting.

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The levels of the neutrophil elastase in the amniotic fluid of pregnant women whose infants develop bronchopulmonary dysplasia

Abstract: The level of amniotic neutrophil elastase cannot be a definitive risk factor for BPD.

Cited by 7 publications

References 27 publications

Association of Chorioamnionitis With Bronchopulmonary Dysplasia Among Preterm Infants

Association of Chorioamnionitis With Bronchopulmonary Dysplasia Among Preterm Infants

Recent advances in our understanding of the mechanisms of late lung development and bronchopulmonary dysplasia

Neutrophil Elastase as a Predictor of Delivery in Pregnant Women with Preterm Labour

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