The Levels of Ghrelin in Children with Cyanotic and Acyanotic Congenital Heart Disease

Al-Asy, Hassan Mohammed; Donia, Amr; El-Amrosy, Doaa M; Rabee, Enaam S.; Bendary, Amal Al

doi:10.17334/jps.46761

Cited by 2 publications

(2 citation statements)

References 17 publications

(16 reference statements)

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“…Al-Asy HM et al study also showed similarity to the present study in which out of 60 cases with CHD BMI was significantly lower in cases than control group (p=0.001). 13 Wishel OF et al study out of 65 cases with CHD almost half of the sample 32 (49.2%) were malnourished in relation to BMI for age. 14 In the present study out of 101 cases with acyanotic CHD, the prevalence of underweight was 83.16% which was significantly higher as compared to 25 cases with cyanotic CHD in which it was 72% (p = 0.009, S).…”

Section: Discussionmentioning

confidence: 96%

Anthropometric assessment in children with congenital heart disease

Rubia

Kher

2018

Int J Contemp Pediatr

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Background: Congenital Heart Diseases (CHD) are often associated with malnutrition with prevalence of 64%. Malnutrition in CHD increases morbidity and mortality in these children and hence it is essential to assess the nutritional status of the children with CHD so that proper nutritional therapy and rehabilitation can be done.Methods: In this case control study 126 cases of un operated CHD in the age group of >28 days to 10 years and 126 age and gender matched controls without CHD were studied during a period of 2 year. Informed consent from the parents was obtained and they were interviewed using pre-validated proforma and relevant clinical examination, detailed anthropometric assessment was done of all cases and control.Results: Male to female ratio was 0.9:1. Maximum cases were in age group of 1 to 5 years. Acyanotic CHD was seen in 80.16% and cyanotic CHD was seen in 19.84%. Stunting was seen in 58.72% cases and in 41.26% of controls. 82.53% of cases and 24.6% of controls were underweight. Conclusions: The prevalence of acyanotic CHD was more common than cyanotic CHD. In acyanotic CHD cases VSD was commonest and in cyanotic CHD cases TOF was the commonest lesion. The overall prevalence of underweight and stunting was high in cases than controls. In acyanotic CHD underweight and stunting was high than cyanotic CHD. In this study malnutrition correlated significantly with congestive heart failure, low hemoglobin level, poor dietary history and pulmonary hypertension and this was statistically highly significant.

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Section: Discussionmentioning

confidence: 96%

Anthropometric assessment in children with congenital heart disease

Rubia

Kher

2018

Int J Contemp Pediatr

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“…In addition, CHD causes chronic hypoxia, resulting in low levels of IGF-1 in the patient's endocrine system. [6][7][8][9][10][11] This analytical study was done in patients who underwent routine medical check-ups at the Pediatrics Cardiology Specialist Unit at Dr. Moewardi Hospital, Surakarta. In our study, there were more female CHD patients (58.7%) than males (41.3%).…”

Section: Discussionmentioning

confidence: 99%

The effect of cyanotic and acyanotic congenital heart disease on children’s growth velocity

Ulfah

Lestari

Salimo

et al. 2017

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Background Congenital heart disease (CHD) can lead to failure to thrive. Decreased energy intake, malabsorption, increased energy requirements, and decreased growth factors (growth hormone/insulin-like growth factor 1 axis) are related to malnutrition and growth retardation in children with CHD.Objective Tocompare the impact of cyanotic and acyanotic CHD on children’s growth velocity (using the 2009 WHO growth velocity chart).Methods This study was conducted in patients less than 24 months of age with CHD in the Pediatric Cardiology Specialist Unit Dr. Moewardi Hospital, Surakarta, Central Java, from December 2016 to February 2017. Subjects’ weights were evaluated at the beginning of the study and two months later. Data were compared to the WHO Growth Velocity chart and analyzed by Chi-square test.Results Of 46 patients with CHD (23 cyanotic, 23 acyanotic), 10 patients (21.7%) were identified with failure to thrive, i.e., < 5th percentile. Significantly more children with acyanotic CHD were in the >5th percentile for growth velocity than were children with cyanotic CHD (OR 5.600; 95%CI 1.038 to 30.204; P=0.032). Acute upper respiratory tract infection was not significantly associated with growth velocity (OR 2.273; 95%CI 0.545 to 9.479; P=0.253).Conclusion Children with cyanotic CHD have 5.6 times higher risk of failure to thrive than children with acyanotic CHD.

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The Levels of Ghrelin in Children with Cyanotic and Acyanotic Congenital Heart Disease

Cited by 2 publications

References 17 publications

Anthropometric assessment in children with congenital heart disease

Anthropometric assessment in children with congenital heart disease

The effect of cyanotic and acyanotic congenital heart disease on children’s growth velocity

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