The Level of vWF Antigen and Coagulation Markers in Hospitalized Patients with Covid-19

Otair, Hadeel Al; Alsaleh, Khalid; AlQahtany, Fatmah S.; Ayed, K; Ammar, Hessah Al; Mefgai, Noura Al; Zeer, Faisal Al

doi:10.2147/jbm.s318940

Cited by 8 publications

(7 citation statements)

References 35 publications

(38 reference statements)

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“…In this study, the median VWF-Ag level was significantly elevated in COVID-19 cases while the median factor VIII and RiCoF levels fell within the normal range. Consistent with our results, previous studies showed that COVID-19 patients showed elevated levels of VWF-Ag ( 8 , 13 , 38 ) with no significant difference in factor VIII levels compared to non-COVID-19 patients ( 39 ). However, studies reported some different findings from our study in this regard, with elevated factor VIIIc levels ( 8 , 13 , 38 , 39 ) and RiCoF activity being detected in COVID-19 patients ( 8 ).…”

Section: Discussionsupporting

confidence: 93%

“…Consistent with our results, previous studies showed that COVID-19 patients showed elevated levels of VWF-Ag ( 8 , 13 , 38 ) with no significant difference in factor VIII levels compared to non-COVID-19 patients ( 39 ). However, studies reported some different findings from our study in this regard, with elevated factor VIIIc levels ( 8 , 13 , 38 , 39 ) and RiCoF activity being detected in COVID-19 patients ( 8 ). Furthermore, factor VIII, RiCoF, and VWF-Ag were significantly elevated in severe and non-survivors in this study.…”

Section: Discussionsupporting

confidence: 93%

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Coagulation Profile in COVID-19 Patients and its Relation to Disease Severity and Overall Survival: A Single-Center Study

El-Lateef¹,

Alghamdi²,

Ebid³

et al. 2022

Br J Biomed Sci

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Objectives: This study aims to investigate hemostatic changes in patients with coronavirus disease (COVID-19) and their relationship to disease severity and survival.Methods: This study included 284 patients with COVID-19 who attended the Security Forces Hospital, Makkah, Saudi Arabia between October 2020 and March 2021, and retrospectively reviewed their demographic, radiological, and laboratory findings. The coagulation profile was assayed at the time of diagnosis for platelet counts using an automated hematology analyzer; Sysmex XN2000 while international normalized ratio (INR), activated partial thromboplastin time (aPTT), fibrinogen, D-dimer, factor VIII, ristocetin cofactor (RiCoF), and von Willebrand factor antigen (VWF-Ag) were measured by Stago kits on a Stago automated coagulation analyzer (STA Compact Max®).Results: In this study, 32.3% of the cases had severe disease, while 8.8% of the cases died. D-dimer, factor VIII, and RiCoF were the only independent predictors of disease severity, with factor VIII and RiCoF having significantly higher areas under the curve (AUCs) than D-dimer (all p < 0.001). Furthermore, age, aPTT, and factor VIII were associated with an increased risk of mortality in multivariate Cox regression analysis, with factor VIII having a higher AUC of 0.98 than aPTT with an optimal cut-off value of >314 IU/dl in predicting mortality. Cases with factor VIII levels >314 IU/dl, compared to those with factor VIII levels <314 IU/dl, were associated with a significantly shorter mean overall survival time (20.08 vs. 31.35 days, p < 0.001), a lower survival rate (30.3% vs. 99.2%, p < 0.001), and a 16.62-fold increased mortality risk.Conclusion: RiCoF is a novel predictor of disease severity in COVID-19, while factor VIII is confirmed as a predictor of severity and mortality in COVID-19 patients and is associated with lower overall survival and increased mortality risk.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Coagulation Profile in COVID-19 Patients and its Relation to Disease Severity and Overall Survival: A Single-Center Study

El-Lateef¹,

Alghamdi²,

Ebid³

et al. 2022

Br J Biomed Sci

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“…Given the very recent interest in the involvement of the vascular endothelium in the pathogenesis of COVID-19, only a few reports have described relationships between disease severity and outcome with elevations in systemic biomarkers of endothelial activation and dysfunction such as von Willebrand factor and thrombomodulin (110)(111)(112). The paucity of reports focused on this important topic underscores the necessity for more intensive investigation.…”

Section: Nucleocapsid Proteinmentioning

confidence: 99%

Emerging Role of Platelet-Endothelium Interactions in the Pathogenesis of Severe SARS-CoV-2 Infection-Associated Myocardial Injury

et al. 2022

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Cardiovascular dysfunction and disease are common and frequently fatal complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Indeed, from early on during the SARS-CoV-2 virus pandemic it was recognized that cardiac complications may occur, even in patients with no underlying cardiac disorders, as part of the acute infection, and that these were associated with more severe disease and increased morbidity and mortality. The most common cardiac complication is acute cardiac injury, defined by significant elevation of cardiac troponins. The potential mechanisms of cardiovascular complications include direct viral myocardial injury, systemic inflammation induced by the virus, sepsis, arrhythmia, myocardial oxygen supply-demand mismatch, electrolyte abnormalities, and hypercoagulability. This review is focused on the prevalence, risk factors and clinical course of COVID-19-related myocardial injury, as well as on current data with regard to disease pathogenesis, specifically the interaction of platelets with the vascular endothelium. The latter section includes consideration of the role of SARS-CoV-2 proteins in triggering development of a generalized endotheliitis that, in turn, drives intense activation of platelets. Most prominently, SARS-CoV-2–induced endotheliitis involves interaction of the viral spike protein with endothelial angiotensin-converting enzyme 2 (ACE2) together with alternative mechanisms that involve the nucleocapsid and viroporin. In addition, the mechanisms by which activated platelets intensify endothelial activation and dysfunction, seemingly driven by release of the platelet-derived calcium-binding proteins, SA100A8 and SA100A9, are described. These events create a SARS-CoV-2–driven cycle of intravascular inflammation and coagulation, which contributes significantly to a poor clinical outcome in patients with severe disease.

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“…The new coronavirus, 2019-nCoV, was isolated from airway epithelial cells. The most prevalent symptoms associated with COVID-19 were fever, coughing, headache, expectoration, muscle aches or fatigue, frequent bowel movements, and hemoptysis, as well as aberrant features on chest computerized tomography [1], [2], [3], [4], [5]. These signs and symptoms are associated with raised inflammatory respone in the form of adult respiratory syndrome , sepsis, coagulapoathy and high mortality [6].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Level of Protein C in Hospitalized Iraqi Patients with COVID-19 and its Correlation with Hematological and Inflammatory Markers

Al-Mamoori

Ahmed

Al-Nafie

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: COVID-19 coagulopathy manifests by elevation of certain marker of active coagulation as fibrinogen and this increment associated with increased markers of inflammations. AIM: To measure protein C (PC) level in hospitalized patients with COVID-19 and to find a possible correlation with hematological and inflammatory markers. PATIENTS AND METHODS: Seventy-five hospitalized Iraqi adult patients with COVID-19 were included in a descriptive cross-sectional research. PC, D-dimer, and erythrocyte sedimentation rate (ESR) blood samples were collected, and further information was received from patient’s records. Statistical analysis was conducted using SPSS version 23 and Microsoft Office Excel 2019. RESULTS: Mean age of 75 patients included in the study was 60.13 ± 14.65 years. Sixty-two (62.7%) of patients exhibited neutrophilia, whereas 41 had lymphopenia (54.7%). High ratio of neutrophil/lymphocyte (N/L) was seen in 66 (88.0%), eosinopenia was seen in 46 (61.3%), high lactate dehydrogenase level was seen 68 (90.7%), serum ferritin was high in 66 (88.0%), and high level of C-reactive protein was seen in 68 (90.7%), increased ESR was seen in 69 (92.0%) and high level of D-dimer was seen in 56 (74.7%), while low level of PC was seen in 12 (16.0%) patients. PC had significant negative correlation with prothrombin and partial thromboplastin time but no significant correlation with hematological and inflammatory parameters. CONCLUSION: COVID-19 coagulopathy is common in majority of patients which include significant changes in WBCs counts, inflammatory markers, PC, and D-dimer levels. Such changes may have a great impact on morbidity and mortality and thus need to be monitored throughout treatment and convalescence.

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The Level of vWF Antigen and Coagulation Markers in Hospitalized Patients with Covid-19

Cited by 8 publications

References 35 publications

Coagulation Profile in COVID-19 Patients and its Relation to Disease Severity and Overall Survival: A Single-Center Study

Coagulation Profile in COVID-19 Patients and its Relation to Disease Severity and Overall Survival: A Single-Center Study

Emerging Role of Platelet-Endothelium Interactions in the Pathogenesis of Severe SARS-CoV-2 Infection-Associated Myocardial Injury

Assessment of the Level of Protein C in Hospitalized Iraqi Patients with COVID-19 and its Correlation with Hematological and Inflammatory Markers

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