The Level of Serum Anti-Müllerian Hormone Correlates with Vitamin D Status in Men and Women But Not in Boys

Dennis, Nicola A.; Houghton, Lisa A; Jones, Gregory T.; Rij, André M. van; Morgan, Kirstie; McLennan, Ian S.

doi:10.1210/jc.2012-1213

Cited by 156 publications

(125 citation statements)

References 37 publications

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“…Previous studies were investigated the relationship between vitamin D and ovarian reserve status. Although our results do not agree with these studies, human studies have reported positive correlations between serum 25(OH) D and AMH levels (11,16,17). Merhi et al found a weak negative association between vitamin D and AMH levels in women under 35 years of age and a weak positive relationship above 40 years of age (10).…”

Section: Discussioncontrasting

confidence: 99%

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Vitamin D Does not Have Any Impact on Ovarian Reserve Markers in Infertile Women

Görkem

Küçükler²,

Toğrul³

et al. 2017

Gynecol Obstet Reprod Med

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OBJECTIVE:To evaluate the potential role of vitamin D on ovarian reserve markers in infertile women with different reserve patterns. STUDY DESIGN:This prospective cross-sectional study included the infertile women attending the Hitit University Hospital. The initial examination included the measurements of waist circumference and hip circumference, body mass index, and waist/hip ratio. A total of 171 women were divided into three groups according to ovarian reserve patterns: (i) adequate ovarian reserve pattern (AOR, n=77), (ii) high ovarian reserve pattern (polycystic ovarian syndrome, n=62), and (iii) diminished ovarian reserve pattern (DOR, n=32). The serum estradiol (E2), follicle stimulating hormone, total testosterone, 17-hydroxyprogesterone (17 (OH) P), dehydroepiandrosterone sulfate, anti-mullerian hormone, and hydroxycholecalciferol (25 (OH) D) levels were analyzed. RESULTS:No significant difference between three different groups was detected in terms of body mass index, waist circumference, hip circumference, waist/hip ratio, E2 and 17OHP levels (p>0.05, for all). One-hundred-sixty-nine (98.2%) women in all groups had vitamin D concentration below 30 ng/mL as a cut-off value. The circulating 25 (OH) D levels did not show a significant difference between all ovarian reserve groups (p=0.804). No correlation between 25 (OH) D and anti-mullerian hormone levels was documented in women with AOR, polycystic ovarian syndrome and DOR patterns (r=-0.099 p=0.393, r=0.034 p=0.794 and r=0.157 p=0.390 respectively). 25 (OH) D levels were significantly correlated with body mass index, waist circumference and hip circumference parameters only in AOR group (r=-0.355 p=0.002, r=-0.305 p=0.007 and r=-0.322 p=0.004 respectively). CONCLUSIONS:There is no association between 25 (OH) D and ovarian reserve markers. 25 (OH) D levels were significantly correlated with body mass index, waist circumference and hip circumference parameters only in AOR group.

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Section: Discussioncontrasting

confidence: 99%

“…However, serum AMH levels were mostly very low and even sometimes non-measurable as expected in such women. Dennis et al conducted a study, which was one of first studies reporting that vitamin D might exert a positive impact on AMH production (16). Nevertheless, the study population was small and did not consider the ovarian status.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Does not Have Any Impact on Ovarian Reserve Markers in Infertile Women

Görkem

Küçükler²,

Toğrul³

et al. 2017

Gynecol Obstet Reprod Med

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“…Although AMH is one of the best markers of ovarian reserve, it has been shown to be altered by environmental factors such as obesity and vitamin deficiencies [6,[8][9][10][11]. For instance, we have recently shown that circulating vitamin D level may play a role in predicting serum AMH especially in late reproductive-aged women who are more likely to have DOR than early reproductive-aged women [7].…”

Section: Discussionmentioning

confidence: 99%

“…Serum AMH levels estimate ovarian reserve and the proximity of menopause [3]. Although we and others [4][5][6][7][8][9][10][11][12] have recently shown that Capsule AMH of 0.2 ng/mL appears to be a clinically meaningful cutoff for predicting a relatively "good" clinical pregnancy rate in women with severely diminished ovarian reserve at our practice. serum AMH is affected by several factors including obesity, serum leptin and serum vitamin D; AMH remains one of the most reliable markers of ovarian reserve and is commonly used in assisted reproductive technology (ART) as a predictor of ovarian response in ovarian stimulation protocols in women with normal or diminished ovarian reserve (DOR) [13][14][15].…”

Section: Introductionmentioning

confidence: 95%

Determining an anti-mullerian hormone cutoff level to predict clinical pregnancy following in vitro fertilization in women with severely diminished ovarian reserve

Merhi

Zapantis

Berger

et al. 2013

J Assist Reprod Genet

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Purpose Serum anti-Mullerian hormone (AMH) levels estimate ovarian reserve. The purpose of this study was to identify a minimum serum AMH level that correlates with acceptable clinical pregnancy rate (CPR) in women with severe diminished ovarian reserve (DOR) undergoing in vitro fertilization (IVF). Methods(s) A historical cohort of severe DOR participants (age ≥35) with day 3 FSH of >10 ng/mL were included (n =120). Participants were categorized into 3 groups: AMH <0.2 (Group 1, n =38), AMH=0.2-0.79 (Group 2, n =57) and AMH≥0.8 (Group 3, n =25) ng/mL. The main outcome was CPR. The number of retrieved and mature oocytes, transferred embryos, spontaneous abortion (SAB) and live birth (LB) rates were also evaluated. Result(s) Among the three groups, there was no difference in day 3 FSH and estradiol, total gonadotropins dose used per cycle, or LB. Participants in Group 1 were two years older than those in Group 2 and had significantly higher BMI than those in Groups 2 and 3. The three groups significantly differed in AFC (Group 1< Group 2< Group 3; p =0.001) and cycle cancellation rate (Group 1> Group 2> Group 3; p =0.006), and had a trend toward significance in SAB rate (Group 1> Group 2> Group 3; p =0.06). Group 3 had significantly more retrieved and mature oocytes than Groups 1 or 2. Group 2 and 3 had significantly higher CPR per cycle start compared to Group 1. Although Group 2 had significantly fewer oocytes retrieved and mature oocytes than Group 3, CPR per cycle start for both groups was not different. ROC curve indicated that the point of maximal inflection between lower and higher CPR represents an AMH value of 0.2 ng/mL. Conclusion(s) AMH of 0.2 ng/mL appears to be a meaningful threshold for predicting CPR in women with severe DOR at our practice. This information can be crucial during the precycle counseling of these women.

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“…It has been also reported that AMH level increases with increasing serum 25-hydroxyvitamin D (25OH-D) level in women ≥40 years of age 5) 6) . In addition to serum vitamin D levels, premenopausal women show seasonal variations in serum AMH levels, showing an 18% decrease in serum AMH levels in winter compared to summer 5) . Vitamin D has also been shown to affect AMH gene expression in vitro 7) .…”

mentioning

confidence: 99%

Decreased Serum Anti-Müllerian Hormone Level Is Associated with Vitamin D Deficiency in Healthy Japanese Women

Honda

Suzuki

Sato

et al. 2016

Juntendo Medical Journal

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The Level of Serum Anti-Müllerian Hormone Correlates with Vitamin D Status in Men and Women But Not in Boys

Abstract: Vitamin D may be a positive regulator of AMH production in adults, and vitamin D deficiency may confound clinical decisions based on AMH. Vitamin D deficiency should be considered when serum AMH levels are obtained for diagnosis.

Cited by 156 publications

References 37 publications

Vitamin D Does not Have Any Impact on Ovarian Reserve Markers in Infertile Women

Vitamin D Does not Have Any Impact on Ovarian Reserve Markers in Infertile Women

Determining an anti-mullerian hormone cutoff level to predict clinical pregnancy following in vitro fertilization in women with severely diminished ovarian reserve

Decreased Serum Anti-Müllerian Hormone Level Is Associated with Vitamin D Deficiency in Healthy Japanese Women

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The Level of Serum Anti-Müllerian Hormone Correlates with Vitamin D Status in Men and Women But Not in Boys

Abstract: Vitamin D may be a positive regulator of AMH production in adults, and vitamin D deficiency may confound clinical decisions based on AMH. Vitamin D deficiency should be considered when serum AMH levels are obtained for diagnosis.

Cited by 156 publications

References 37 publications

Vitamin D Does not Have Any Impact on Ovarian Reserve Markers in Infertile Women

Vitamin D Does not Have Any Impact on Ovarian Reserve Markers in Infertile Women

Determining an anti-mullerian hormone cutoff level to predict clinical pregnancy following in vitro fertilization in women with severely diminished ovarian reserve

Decreased Serum Anti-M&uuml;llerian Hormone Level Is Associated with Vitamin D Deficiency in Healthy Japanese Women

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Decreased Serum Anti-Müllerian Hormone Level Is Associated with Vitamin D Deficiency in Healthy Japanese Women