The level of peripheral blood circulating CD34+ cells is higher in acute promyelocytic leukemia patients with adverse prognostic factors

Zeng, Hui; Yin, Lingdi; Li, Ping; Yuan, Yihang; Guan, Chaoyang; Xie, Tongxin; Zhang, Qiguo

doi:10.1080/10245332.2016.1150410

Cited by 6 publications

(1 citation statement)

References 12 publications

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“…Evaluation of the full text was performed for 242 studies, of which 218 were excluded given the lack of outcome or mutations of interest. Finally, a total of 24 articles were included in this systematic review [13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36], as shown in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

The Impact of Flt3 Gene Mutations in Acute Promyelocytic Leukemia: A Meta-Analysis

Picharski

Andrade

Fabro

et al. 2019

Cancers

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The association of FLT3 mutations with white blood cell (WBC) counts at diagnosis and early death was studied in patients with acute promyelocytic leukemia (APL). Publications indexed in databases of biomedical literature were analyzed. Potential publication bias was evaluated by analyzing the standard error in funnel plots using the estimated relative risk (RR). Mixed-effect models were used to obtain the consolidated RR. All analyses were conducted using the R statistical software package. We used 24 publications in the final meta-analysis. Of 1005 males and 1376 females included in these 24 publications, 645 had FLT3-ITD (internal tandem duplication) mutations. Information on FLT3-D835 mutations was available in 10 publications for 175 patients. Concurrent occurrence of the two mutations was rare. WBC count at diagnosis was ≥10 × 109/L in 351 patients. For patients with the FLT3-ITD mutation, RR was 0.59 for overall survival (OS) and 1.62 for death during induction. For those with FLT3-D835 mutations, the RR was 0.50 for OS and 1.77 for death during induction. RR for WBC count ≥10 × 109/L was 3.29 and 1.48 for patients with FLT3-ITD and FLT3-D835, respectively. APL patients with FLT3-ITD or FLT3-D835 are more likely to present with elevated WBC counts and poorer prognosis than those without these mutations.

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Section: Resultsmentioning

confidence: 99%

The Impact of Flt3 Gene Mutations in Acute Promyelocytic Leukemia: A Meta-Analysis

Picharski

Andrade

Fabro

et al. 2019

Cancers

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Arsenic‐induced transition of thymic inflammation‐to‐fibrosis involves Stat3‐Twist1 interaction: Melatonin to the rescue

Das,

Mitra,

Ghosh

et al. 2024

BioFactors

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Groundwater arsenic is a notorious toxicant and exposure to environmentally relevant concentrations persists as a healthcare burden across the world. Arsenic has been reported to jeopardize the normal functioning of the immune system, but there are still gaps in the understanding of thymic T cell biology. Immunotoxic influence of arsenic in thymic integrity demands a potent restorative molecule. The objectives of this study were to examine key signaling cross‐talks associated with arsenic‐induced immune alterations in the thymus and propose melatonin as a potential candidate against immunological complications arising from arsenic exposure. Swiss albino mice were exposed to sodium arsenite (0.05 mg/L; in drinking water) and melatonin (IP:10 mg/kg BW) for 28 days. Melatonin successfully protected thymus from arsenic‐mediated tissue degeneration and maintained immune homeostasis including T cell maturation and proliferation by mitigating oxidative stress through Nrf2 upregulation. Additionally, melatonin exerted ameliorative effect against arsenic‐induced apoptosis and inflammation by inhibiting p53‐mediated mitochondrial cell death pathway and NF‐κB‐p65/STAT3‐mediated proinflammatory pathway, respectively. For the first time, we showed that arsenic‐induced profibrotic changes were inhibited by melatonin through targeting of inflammation‐associated EMT. Our findings clearly demonstrate that melatonin can be a viable and promising candidate in combating arsenic‐induced immune toxicity with no collateral damage, making it an important research target.

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Higher Level of Peripheral Blood CD34 Positive Cells Presented with Unfavorable Prognosis in Intermediate-Low Risk Acute Promyelocytic Leukemia

Zhang

Dong

Lin

et al. 2019

Indian J Hematol Blood Transfus

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The level of peripheral blood circulating CD34+ cells is higher in acute promyelocytic leukemia patients with adverse prognostic factors

Abstract: The circulating CD34+ cell count appears to increase in some APL patients and a higher CD34+ cell count may be indicative of inferior survival and serve as an adverse biomarker for APL.

Cited by 6 publications

References 12 publications

The Impact of Flt3 Gene Mutations in Acute Promyelocytic Leukemia: A Meta-Analysis

The Impact of Flt3 Gene Mutations in Acute Promyelocytic Leukemia: A Meta-Analysis

Arsenic‐induced transition of thymic inflammation‐to‐fibrosis involves Stat3‐Twist1 interaction: Melatonin to the rescue

Higher Level of Peripheral Blood CD34 Positive Cells Presented with Unfavorable Prognosis in Intermediate-Low Risk Acute Promyelocytic Leukemia

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