The level of monocyte turnover predicts disease progression in the macaque model of AIDS

Hasegawa, Atsuhiko; Liu, Huining; Ling, Binhua; Borda, Juan T.; Álvarez, Xavier; Sugimoto, Chie; Vinet-Oliphant, Heather; Kim, Woong‐Ki; Williams, Kenneth C.; Ribeiro, Ruy M.; Lackner, Andrew A.; Veazey, Ronald S.; Kuroda, Marcelo J.

doi:10.1182/blood-2009-02-204263

Cited by 131 publications

(176 citation statements)

References 36 publications

Supporting

Mentioning

155

Contrasting

Unclassified

Order By: Relevance

“…CD8 þ lymphocytes were depleted to achieve rapid AIDS (3 to 4 months) with >75% incidence of SIVE. 14,17,18,44 Although there is an increase in the number of monocytes, macrophages, and virus in the CNS of CD8 þ lymphocyte depleted compared with nondepleted animals, the neuropathology with SIVE is the same. A chimeric anti-CD8 antibody, cM-T807 (NIH Non-Human Primate Reagent Resource, Boston, MA), was administered s.c. (10 mg/kg) at 6 dpi and i.v.…”

Section: Ethics Statementmentioning

confidence: 99%

SIV Encephalitis Lesions Are Composed of CD163+ Macrophages Present in the Central Nervous System during Early SIV Infection and SIV-Positive Macrophages Recruited Terminally with AIDS

Nowlin

Burdo

Midkiff

et al. 2015

The American Journal of Pathology

Self Cite

View full text Add to dashboard Cite

Macrophage recruitment to the central nervous system (CNS) during AIDS pathogenesis is poorly understood. We measured the accumulation of brain perivascular (CD163 þ ) and inflammatory (MAC387 þ ) macrophages in SIV-infected monkeys. Monocyte progenitors were 5-bromo-2 0 -deoxyuridine (BrdU) labeled in bone marrow, and CNS macrophages were labeled serially with fluorescent dextrans injected into the cisterna magna. MAC387 þ macrophages accumulated in the meninges and choroid plexus in early inflammation and in the perivascular space and SIV encephalitis (SIVE) lesions late. CD163 þ macrophages accumulated in the perivascular space and SIVE lesions with late inflammation. Most of the BrdU þ cells were MAC387 þ ; however, CD163 þ BrdU þ macrophages were present in the meninges and choroid plexus with AIDS. Most (81.6% AE 1.8%) of macrophages in SIVE lesions were present in the CNS before SIVE lesion formation. There was a 2.9-fold increase in SIVp28 þ macrophages entering the CNS late compared with those entering early (P < 0.05). The rate of CD163 þ macrophage recruitment to the CNS inversely correlated with time to death (P < 0.03) and increased with SIVE. In SIVE animals, soluble CD163 correlated with CD163 þ macrophage recruitment (P Z 0.02). Most perivascular macrophages that comprise SIVE lesions and multinucleated giant cells are present in the CNS early, before SIVE lesions are formed. Most SIV-infected macrophages traffic to the CNS terminally with AIDS.

show abstract

Section: Ethics Statementmentioning

confidence: 99%

SIV Encephalitis Lesions Are Composed of CD163+ Macrophages Present in the Central Nervous System during Early SIV Infection and SIV-Positive Macrophages Recruited Terminally with AIDS

Nowlin

Burdo

Midkiff

et al. 2015

The American Journal of Pathology

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, while the monocyte:lymphocyte ratio seemed to give the best predictive value in the HIV-infected individuals, observations from the present study in HIV-negative TB contacts suggested that the peripheral blood monocyte rate alone can identify elevated risk of progression to active TB, and when combined with a strong TST response gave a better risk association than the monocyte: lymphocyte ratio according to the AIC obtained from the different models. The effect of HIV on lymphocyte and leukocyte numbers [31] could explain the differences observed in these HIV-positive and -negative populations.…”

Section: Discussionmentioning

confidence: 99%

Biomarkers for risk of developing active tuberculosis in contacts of TB patients: a prospective cohort study

et al. 2015

View full text Add to dashboard Cite

Identifying those Mycobacterium tuberculosis latent-infected individuals most at risk of developing active tuberculosis (TB) using routine clinical and laboratory tests remains a huge challenge in TB control efforts. We conducted a prospective longitudinal study of clinical and laboratory markers associated with the risk of developing active TB in contacts with latent M. tuberculosis infection.HIV-negative household contacts (n=296) of pulmonary TB patients underwent monitoring of clinical features, full blood cell counts, tuberculin skin text (TST) and chest radiography performed regularly during 18 months of follow-up. Paired statistical tests, a Kaplan-Meier analysis and Cox proportional hazard modelling were performed on variables between contacts progressing or not progressing to active TB.The appearance of TB disease symptoms in contacts was significantly associated with an elevated peripheral percentage of blood monocytes (adjusted hazard ratio (aHR) 6.25, 95% CI 1.63-23.95; p<0.01), a ⩾14 mm TST response (aHR 5.72, 95% CI 1.22-26.80; p=0.03) and an increased monocyte:lymphocyte ratio (aHR 4.97, 95% CI 1.3-18.99; p=0.03). Among contacts having TST ⩾14 mm, a strong association with risk of progression to TB was found with an elevated blood monocyte percentage (aHR 8.46, p<0.01).Elevated percentage of peripheral blood monocytes plus an elevated TST response are potential biomarkers for identifying contacts of TB patients at highest risk of developing active TB. @ERSpublications Tuberculin skin tests combined with monocyte count improve evaluation of disease progression risk among TB contacts

show abstract

“…Changes in these cells have been shown to correlate with disease progression (23,27,28,34,57). Others have shown that the level of monocyte turnover predicted disease progression in SIV-infected rhesus macaques (5,15). Igarashi et al (16) showed that macrophages were a principal reservoir in rhesus macaques after the depletion of CD4 T cells during SHIV infection, whereas macrophage-tropic SHIV-SF162 has been shown to infect rhesus macaques efficiently (33).…”

mentioning

confidence: 99%

Mucosal and Peripheral Lin ⁻ HLA-DR ⁺ CD11c/123 ⁻ CD13 ⁺ CD14 ⁻ Mononuclear Cells Are Preferentially Infected during Acute Simian Immunodeficiency Virus Infection

Moore

Bixler

Lewis

et al. 2012

J Virol

View full text Add to dashboard Cite

Massive infection of memory CD4 T cells is a hallmark of early simian immunodeficiency virus (SIV) infection, with viral infectionHere we show that, at day 10 p.i., Lin ؊ HLA-DR ؉ CD11c/123 ؊ CD13 ؉ CD14 ؊ macrophages in the jejunal mucosa were infected, albeit at lower levels than CD4 memory T cells. Interestingly, Lin ؊ HLA-DR ؉ CD11c/123 ؊ CD13 ؉ CD14 ؊ macrophages in peripheral blood, like their mucosal counterparts, were preferentially infected compared to Lin ؊ HLA-DR ؉ CD11c/123 ؊ CD13 ؉ CD14 ؉ monocytes, suggesting that differentiated macrophages were selectively infected by SIV. CD13 ؉ CD14 ؊ macrophages expressed low levels of CD4 compared to CD4 T cells but expressed similar levels of CCR5 as lymphocytes. Interestingly, CD13 ؉ CD14 ؊ macrophages expressed Apobec3G at lower levels than CD13 ؉ CD14 ؉ monocytes, suggesting that intracellular restriction may contribute to the differential infection of mononuclear subsets. Taken together, our results suggest that CD13 ؉ CD14 ؊ macrophages in mucosal and peripheral tissues are preferentially infected very early during the course of SIV infection.

show abstract

The level of monocyte turnover predicts disease progression in the macaque model of AIDS

Cited by 131 publications

References 36 publications

SIV Encephalitis Lesions Are Composed of CD163+ Macrophages Present in the Central Nervous System during Early SIV Infection and SIV-Positive Macrophages Recruited Terminally with AIDS

SIV Encephalitis Lesions Are Composed of CD163+ Macrophages Present in the Central Nervous System during Early SIV Infection and SIV-Positive Macrophages Recruited Terminally with AIDS

Biomarkers for risk of developing active tuberculosis in contacts of TB patients: a prospective cohort study

Mucosal and Peripheral Lin ⁻ HLA-DR ⁺ CD11c/123 ⁻ CD13 ⁺ CD14 ⁻ Mononuclear Cells Are Preferentially Infected during Acute Simian Immunodeficiency Virus Infection

Contact Info

Product

Resources

About

The level of monocyte turnover predicts disease progression in the macaque model of AIDS

Cited by 131 publications

References 36 publications

SIV Encephalitis Lesions Are Composed of CD163+ Macrophages Present in the Central Nervous System during Early SIV Infection and SIV-Positive Macrophages Recruited Terminally with AIDS

SIV Encephalitis Lesions Are Composed of CD163+ Macrophages Present in the Central Nervous System during Early SIV Infection and SIV-Positive Macrophages Recruited Terminally with AIDS

Biomarkers for risk of developing active tuberculosis in contacts of TB patients: a prospective cohort study

Mucosal and Peripheral Lin − HLA-DR + CD11c/123 − CD13 + CD14 − Mononuclear Cells Are Preferentially Infected during Acute Simian Immunodeficiency Virus Infection

Contact Info

Product

Resources

About

Mucosal and Peripheral Lin ⁻ HLA-DR ⁺ CD11c/123 ⁻ CD13 ⁺ CD14 ⁻ Mononuclear Cells Are Preferentially Infected during Acute Simian Immunodeficiency Virus Infection