The level of free-circulating mtDNA in patients with radon-induced lung cancer

Bulgakova, Olga; Kussainova, Assiya; Kakabayev, Anuarbek; Aripova, Akmaral; Baikenova, G. E.; Izzotti, Alberto; Bersimbaev, R. I.

doi:10.1016/j.envres.2021.112215

Cited by 13 publications

(10 citation statements)

References 49 publications

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“…The authors suggested that excess cf-mtDNA may be a biomarker of radiation-induced stress during spaceflight. We have also demonstrated that radon, a radioactive gas, increases the level of cf-mtDNA both in patients with radon-induced lung cancer and in individuals living in areas with high radon levels, which confirms the role of cf-mtDNA as a promising biomarker of radiation exposure [64].…”

Section: Mitochondrial Dysfunctionsupporting

confidence: 69%

“…The mtDNA deletion is Δ-mtDNA 4977 , the most commonly considered a somatic mutation, which increases with age during the progression of mitochondrial dysfunction [ 63 ]. Free-circulating mtDNA (cf-mtDNA) is another favored non-invasive biomarker for multiple diseases; for example, it has been used to diagnose various cancers [ 64 , 65 , 66 , 67 ]. Recently, cf-mtDNA has been used as a predictive marker of the age-related phenotype [ 68 , 69 , 70 ].…”

Section: Inducers and Key Signatures Of Cellular Senescencementioning

confidence: 99%

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The Molecular Mechanisms in Senescent Cells Induced by Natural Aging and Ionizing Radiation

Ibragimova,

Kussainova,

Aripova

et al. 2024

Cells

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This review discusses the relationship between cellular senescence and radiation exposure. Given the wide range of ionizing radiation sources encountered by people in professional and medical spheres, as well as the influence of natural background radiation, the question of the effect of radiation on biological processes, particularly on aging processes, remains highly relevant. The parallel relationship between natural and radiation-induced cellular senescence reveals the common aspects underlying these processes. Based on recent scientific data, the key points of the effects of ionizing radiation on cellular processes associated with aging, such as genome instability, mitochondrial dysfunction, altered expression of miRNAs, epigenetic profile, and manifestation of the senescence-associated secretory phenotype (SASP), are discussed. Unraveling the molecular mechanisms of cellular senescence can make a valuable contribution to the understanding of the molecular genetic basis of age-associated diseases in the context of environmental exposure.

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Section: Mitochondrial Dysfunctionsupporting

confidence: 69%

Section: Inducers and Key Signatures Of Cellular Senescencementioning

confidence: 99%

The Molecular Mechanisms in Senescent Cells Induced by Natural Aging and Ionizing Radiation

Ibragimova,

Kussainova,

Aripova

et al. 2024

Cells

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“…After smoking, exposure to radon is the second leading cause of LC (Lorenzo-González et al, 2019). A study found that in radoninduced LC patients, the concentration of cell free mtDNA was significantly increased compared to other participants in the study (Bulgakova et al, 2022). Although these studies suggested a relationship between MPs and LC to some degree, the causal links remain unclear, and the direct association between them still lacks substantial research backing.…”

Section: Discussionmentioning

confidence: 99%

Causal relationships between mitochondrial proteins and different pathological types of lung cancer: a bidirectional mendelian randomization study

Ji,

Lv,

Liu

et al. 2024

Front. Genet.

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An increasing number of studies point to an association between mitochondrial proteins (MPs) and lung cancer (LC). However, the causal relationship between MPs and LC remains unclear. Consequently, our study employed a bidirectional Mendelian randomization (MR) analysis to explore the causal association between MPs and different pathological types of LC. A two-sample MR study was performed using the genome-wide association study (GWAS) data publicly available. We applied the primary inverse variance weighted (IVW) method along with additional MR methods to validate the causality between MPs and different pathological types of LC. To ensure the robustness of our findings, sensitivity analyses were employed. Moreover, we performed a bi-directional MR analysis to determine the direction of the causal association. We identified a total of seven MPs had significant causal relationships on overall LC, lung squamous cell carcinoma (LUSC), and small cell lung carcinoma (SCLC). We found two MPs had significant associations with overall LC, four MPs had significant associations with LUSC, and four MPs had significant associations with SCLC. Additionally, an MP was found to have a nominal relationship with LUSC. Moreover, no causality was found between MPs and lung adenocarcinoma (LUAD). Bidirectional MR showed no reverse effect between identified MPs and different pathological types of LC. In general, our findings of this MR study suggest causal associations of specific MPs with overall LC, LUSC, and SCLC. However, no such causality was found in LUAD.

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“…However, as for freely circulating mtDNA, it is worth noting that in the case of exposure to aggressive factors, such as tobacco smoke, radon, or asbestos, an increase in the level of cf-MtDNA and proinflammatory cytokines in the plasma of patients with NSCLC occurs, which correlates with the poor prognosis of the survival rate [ 133 ]. It was noted that cf-mtDNA levels increased in patients with radon-induced lung cancer and in healthy donors living in areas with high radon levels [ 134 ]. This can be explained by the fact that the main provocateurs of lung tissue carcinogenesis (smoking and radon) increase the production of ROS, which, in turn, damages various structural parts of cells including the lipid bilayer of mitochondrial membranes.…”

Section: The Role Of Mitochondria and Mtdna In The Development Of Lun...mentioning

confidence: 99%

The Role of Mitochondrial miRNAs in the Development of Radon-Induced Lung Cancer

et al. 2022

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MicroRNAs are short, non-coding RNA molecules regulating gene expression by inhibiting the translation of messenger RNA (mRNA) or leading to degradation. The miRNAs are encoded in the nuclear genome and exported to the cytosol. However, miRNAs have been found in mitochondria and are probably derived from mitochondrial DNA. These miRNAs are able to directly regulate mitochondrial genes and mitochondrial activity. Mitochondrial dysfunction is the cause of many diseases, including cancer. In this review, we consider the role of mitochondrial miRNAs in the pathogenesis of lung cancer with particular reference to radon exposure.

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The level of free-circulating mtDNA in patients with radon-induced lung cancer

Cited by 13 publications

References 49 publications

The Molecular Mechanisms in Senescent Cells Induced by Natural Aging and Ionizing Radiation

The Molecular Mechanisms in Senescent Cells Induced by Natural Aging and Ionizing Radiation

Causal relationships between mitochondrial proteins and different pathological types of lung cancer: a bidirectional mendelian randomization study

The Role of Mitochondrial miRNAs in the Development of Radon-Induced Lung Cancer

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