The level of expression of HPV16 early transcripts is not associated with the natural history of cervical lesions
Elise Jacquin,
Maëlle Saunier,
Quentin Lepiller
et al.
Abstract:The natural history of cervical cancer is closely linked to that of high‐risk human papillomaviruses (HPV) infection. It is recognized that upon HPV DNA integration, partial or complete loss of the E2 open reading frame precludes expression of the corresponding protein, resulting in upregulation of the E6 and E7 viral oncoproteins. To better characterize HPV16 infection at the cervical level, viral load, viral DNA integration, and viral early transcript expression (E2, E5, and E6) were analyzed in a series of … Show more
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