The leucocyte migration inhibition test and subpopulations of peripheral lymphocytes in insulin-dependent diabetics.

Nagaoka, Kengo; Sakurami, Takehiko; Nabeya, Noboru; Imura, Hiroo; Kuno, Shotaro

doi:10.1507/endocrj1954.26.89

Cited by 5 publications

(7 citation statements)

References 12 publications

(14 reference statements)

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“…Reported results on T-lymphocyte numbers in IDD disagree [12][13][14][15][16][17]. The metabolic compensation [15], the duration of the illness [25] and the patients' age, which is inversely correlated to the T-lymphocyte absolute number [26], are perhaps relevant.…”

Section: Discussionmentioning

confidence: 99%

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Lymphocyte subpopulations in insulin-dependent diabetics with and without serum islet-cell autoantibodies

et al. 1981

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Summary. The lymphocyte subpopulations of 26insulin-dependent diabetics were studied. Thirteen of them had persistent pancreatic islet-cell serum antibodies (ICA) (mean (+ SD) duration of diabetes 11 + 8 years). The others were ICA-negative (mean duration of diabetes 10 + 8 years). The mean fasting blood glucose in the week before the lymphocyte count was 1.37 _ 0.45 g/l (two specimens for every patient). As controls 19 healthy volunteers, sex and age matched, were investigated. The T-lymphocyte count was no different in diabetics compared to controls~ B-cells were significantb' raised (p <0,0t) in the ICA-positive group, when tested with antihuman gammaglobulin sera (IgG + IgA + IgM), anti-human IgG and anti-human IgM, while' no difference was observed between ICA-negative patients and normal subjects. IgA-bearing lymphocytes were equally raised in both diabetic groups (p <0.05). These data show an altered immunological balance in type IB (autoimmune) diabetes, characterized by an increased number of B-lymphocytes.

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Section: Discussionmentioning

confidence: 99%

“…MacCuish et al [12] and other groups [13,14] did not find significarit differences in the number of T and B cells between diabetic patients and normal subjects, independent of the metab61i~ state. There are reports, however, of a fall in the number of Tlymphocytes, dependent on [15] and independent of [16] metabolic conditions.…”

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confidence: 81%

Lymphocyte subpopulations in insulin-dependent diabetics with and without serum islet-cell autoantibodies

et al. 1981

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“…In Japan, Nagaoka et al ( , 1979 and Sakaguchi et al (1978) also reported decreased M.I. of LMT in IDDM with extracts of human pancreas and rat islet cell mitochondria, respectively.…”

Section: Discussionmentioning

confidence: 92%

“…Nerup et al (1971) first showed anti-pancreatic hypersensitivity in IDDM patients with calf pancreas antigen. Later, several authors (MacCuish et al, 1974;Nagaoka et al, 1979;Sakaguchi et al, 1978) reproduced this phenomenon with the extract of human pancreas.…”

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confidence: 87%

Cellular hypersensitivity to human pancreatic B-cell clone in diabetes mellitus and its relationship to the presence of islet cell antibodies.

et al. 1985

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“…The clinical association between IDD and autoimmune diseases and a high incidence of thyroid or gastric autoantibodies and an antipancreatic cellular hypersensitivity in IDD have already been reported (Hecht et al, 1968;Irvine et al, 1970;Nagaoka et al, 1979;Nerup et al, 1971Nerup et al, , 1973. By mean of the indirect immunofluorescence test, Bottazzo et al(1974) and MacCuish et al(1974) found respectively pancreatic islets cell antibodies (I. C.…”

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confidence: 87%

Antimicrosomal antibodies, gastric parietal cell antibodies and antinuclear factors in insulin dependent diabetes mellitus.

et al. 1979

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antibodies, gastric parietal cell antibodies (PCA) and antinuclear factors were studied in208insulin dependent diabetic (IDD) according to the duration of diabetes and patient's age at the time of testing. Antimicrosomal antibodies were found in11out of47 (23.4%) IDD with the duration of less than one year, however this value declined to13.1% at1to3years, 15.3% at4to5 years, 10.8% at6to10yearsand5.8% at more than10years. Of the47IDD,7 (14.8%) were positive for gastric parietal cell antibodies.The prevalence of PCA declined with the increasing duration of diabetes.However, this decrease in the prevalence of antimicrosomal antibodies and PCA was not so extreme as that of pancreatic islet cell antibodies.Antinuclear factors did not reveal a significant correlation with the duration of diabetes.In normal controls, the prevalence of antimicrosomal antibodies, PCA and the antinuclear factors increased progressively with age. In IDD, the prevalence of the antinuclear factors was also progressively greater with age. However, the prevalence of antimicrosomal antibodies in IDD decreased with age and those of PCA showed the lowest percent in the40-69year-age group.There is an increasing evidence that autoimmune mechanism may have a role in the pathogenesis in insulin dependent diabetics (IDD). The clinical association between IDD and autoimmune diseases and a high incidence of thyroid or gastric autoantibodies and an antipancreatic cellular hypersensitivity in IDD have already been reported (Hecht et al., 1968;Irvine et al., 1970;Nagaoka et al., 1979; Nerup et al., 1971 Nerup et al., , 1973. By mean of the indirect immunofluorescence test, Bottazzo et al.(1974) and MacCuish et al.(1974) found respectively pancreatic islets cell antibodies (I. C. Ab.) in IDD with autoimmune polyendocrine disease. Using an improved technique and group-0 fresh human pancreas, Irvine et al.(1977) determined the prevalence of I. C. Ab. in IDD with and without other organ-specific autoimmune disorders and they found that I. C. Ab. declined with the duration. In collaboration with W. J. Irvine, the inverse relationship between the prevalence of I. C. Ab. and the duration of diabetes was already observed by us in Japanese insulin dependent diabetics (Nagaoka et al., 1978). The purpose of the present study was to study the relationship between thyroid antibodies, gastric parietal cell antibodies (PCA) and the duration of diabetes.Received January26, 1979.

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The leucocyte migration inhibition test and subpopulations of peripheral lymphocytes in insulin-dependent diabetics.

Cited by 5 publications

References 12 publications

Lymphocyte subpopulations in insulin-dependent diabetics with and without serum islet-cell autoantibodies

Lymphocyte subpopulations in insulin-dependent diabetics with and without serum islet-cell autoantibodies

Cellular hypersensitivity to human pancreatic B-cell clone in diabetes mellitus and its relationship to the presence of islet cell antibodies.

Antimicrosomal antibodies, gastric parietal cell antibodies and antinuclear factors in insulin dependent diabetes mellitus.

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