The let-7 family of microRNAs

Roush, Sarah F.; Slack, Frank J.

doi:10.1016/j.tcb.2008.07.007

Cited by 1,166 publications

(1,035 citation statements)

References 82 publications

Supporting

Mentioning

990

Contrasting

Unclassified

Order By: Relevance

“…The Let-7 family of miRNAs is expressed ubiquitously in somatic cells, but not in ESCs, and is up-regulated upon ESC differentiation. Their targets include many cell cycle regulators such as CDC25A and cyclinD1 (Roush and Slack, 2008). The mechanism of Lin28's action appears to promote cell cycle progression by suppressing the Let-7 miRNAs, and hence accelerate the reprogramming process (Hanna et al, 2009).…”

Section: Molecular Mechanism Of Reprogramming To Pluripotency the Funmentioning

confidence: 99%

Mechanism and methods to induce pluripotency

Wang

2011

Protein Cell

View full text Add to dashboard Cite

Pluripotent stem cells are able to self-renew indefinitely and differentiate into all types of cells in the body. They can thus be an inexhaustible source for future cell transplantation therapy to treat degenerative diseases which currently have no cure. However, non-autologous cells will cause immune rejection. Induced pluripotent stem cell (iPSC) technology can convert somatic cells to the pluripotent state, and therefore offers a solution to this problem. Since the first generation of iPSCs, there has been an explosion of relevant research, from which we have learned much about the genetic networks and epigenetic landscape of pluripotency, as well as how to manipulate genes, epigenetics, and microRNAs to obtain iPSCs. In this review, we focus on the mechanism of cellular reprogramming and current methods to induce pluripotency. We also highlight new problems emerging from iPSCs. Better understanding of the fundamental mechanisms underlying pluripotenty and refining the methodology of iPSC generation will have a significant impact on future development of regenerative medicine.

show abstract

Section: Molecular Mechanism Of Reprogramming To Pluripotency the Funmentioning

confidence: 99%

Mechanism and methods to induce pluripotency

Wang

2011

Protein Cell

View full text Add to dashboard Cite

show abstract

“…3,4 Members of the Let-7 (Lethal-7) family of miRNAs showed RAS regulating activity. 5 Let-7 induced RAS downregulation after binding to specific sites in the 3 0 untranslated region (3 0 -UTR) of the KRAS mRNA. 6,7 These findings led to growing interest in Let-7 and its role in cancer development and control.…”

Section: Introductionmentioning

confidence: 99%

Genetic modulation of the Let-7 microRNA binding to KRAS 3′-untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab–irinotecan

et al. 2010

View full text Add to dashboard Cite

“…The deregulation of miRNAs in let-7 family often leads to abnormal cell differentiation and development cell-based diseases, such as cancer. What's more, many let-7 family members are located in the genomic regions which are frequently deleted in lung cancer patients (Roush and Slack, 2008;Boyerinas et al, 2010). It is also reported that all of these three miRNAs' expression are altered in lung cancer cell compared to normal controls (Johnson et al, 2007;Boyerinas et al, 2010).…”

Section: Discussionmentioning

confidence: 97%