“…Towards our goal of constructing a chimeritope (chimeric epitope-based protein) vaccinogen for leptospirosis, we have sought to identify immunodominant epitope-containing domains of Leptospira proteins. In a previous study we identified the immunodominant bactericidal epitopes of the General secretory pathway D (GspD) protein [24] . The goal of this study was to identify the antigenic determinants of the Leptospira virulence factor, Loa22 ( Leptospira OmpA-like 22 kDa protein) [25] and assess its potential utility for inclusion in a multi-valent subunit vaccine.…”