The leprous testis

El-beheiry, A. H.; Zeid, S. Abou; El-Ghazzawi, E.; El-Mansy, E.; Salama, Nader

doi:10.3109/01485017908985066

Cited by 7 publications

(6 citation statements)

References 3 publications

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“…Lepromatous leprosy is associated with an increased risk of semen abnormalities and azoospermia with testicular biopsies showing features of spermatogenic arrest as well as complete hyalinization of both seminiferous tubules and interstitial tissue (El-Beheiry et al ., 1979; Saporta and Yuksel, 1994). Data from Tanzania have suggested lower fertility in men and women suffering from malaria although the pathogenesis remains to be explained (Larsen, 1996).…”

Section: Aetiology and Risk Factors For Infertility In Developing Coumentioning

confidence: 99%

Infertility and the provision of infertility medical services in developing countries

Ombelet

Cooke²,

Dyer

et al. 2008

Human Reproduction Update

531

398

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BACKGROUNDWorldwide more than 70 million couples suffer from infertility, the majority being residents of developing countries. Negative consequences of childlessness are experienced to a greater degree in developing countries when compared with Western societies. Bilateral tubal occlusion due to sexually transmitted diseases and pregnancy-related infections is the most common cause of infertility in developing countries, a condition that is potentially treatable with assisted reproductive technologies (ART). New reproductive technologies are either unavailable or very costly in developing countries. This review provides a comprehensive survey of all important papers on the issue of infertility in developing countries.METHODSMedline, PubMed, Excerpta Medica and EMBASE searches identified relevant papers published between 1978 and 2007 and the keywords used were the combinations of ‘affordable, assisted reproduction, ART, developing countries, health services, infertility, IVF, simplified methods, traditional health care'.RESULTSThe exact prevalence of infertility in developing countries is unknown due to a lack of registration and well-performed studies. On the other hand, the implementation of appropriate infertility treatment is currently not a main goal for most international non-profit organizations. Keystones in the successful implementation of infertility care in low-resource settings include simplification of diagnostic and ART procedures, minimizing the complication rate of interventions, providing training-courses for health-care workers and incorporating infertility treatment into sexual and reproductive health-care programmes.CONCLUSIONSAlthough recognizing the importance of education and prevention, we believe that for the reasons of social justice, infertility treatment in developing countries requires greater attention at National and International levels.

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Section: Aetiology and Risk Factors For Infertility In Developing Coumentioning

confidence: 99%

Infertility and the provision of infertility medical services in developing countries

Ombelet

Cooke²,

Dyer

et al. 2008

Human Reproduction Update

531

398

View full text Add to dashboard Cite

show abstract

“…Infertility has been reported in 24% to 28% male patients with leprosy, with oligoazoospermia in 61% to 69% of lepromatous patients. 4 El-Shiemy et al 8 opined that azoospermia was a result of testicular involvement, rather than epididymal obstruction. Abd-Elkawi et al 3 proposed that the degree of testicular involvement, duration of disease, early treatment, and frequency of orchitis in type 2 reactions influenced testicular atrophy, whereas El-Beheiry et al 4 found no relation between duration of disease and testicular involvement.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 Testicular involvement may or may not correlate with disease progression. 2,4 The testes are composed of Leydig cells and seminiferous tubules containing Sertoli cells and germ cells. Leydig cells produce testosterone under regulation by luteinizing hormone (LH), and Sertoli cells are regulated by follicle stimulating hormone (FSH) and androgens.…”

Section: Introductionmentioning

confidence: 99%

Case Report: Successful Outcome of Primary Infertility with Multidrug Therapy in a Long-Standing Case of Hypogonadism Resulting from Lepromatous Leprosy: Shattering the Dogma of Irreversible Infertility in Leprosy

Sinha

Singh

Mathachan

et al. 2022

The American Journal of Tropical Medicine and Hygiene

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We present a case of primary infertility with features of hypogonadism in a male patient with lepromatous leprosy who had remained undiagnosed for 3 years. On investigation, azoospermia and deranged gonadotropin levels with normal serum testosterone were noted and the patient was initiated on multibacillary–multidrug therapy with the primary aim of treating the disease. Although the cutaneous lesions improved within 6 weeks, remarkably, infertility was reversed in 2 months—with concomitant normalization of luteinizing hormone, follicle stimulating hormone, and sperm count—an outcome that was unexpected. While reiterating leprosy as a cause of infertility, considered to be an uncommon cause among endocrinologists, we also discuss the probable mechanism for the efficacy of the WHO multidrug therapy in what seemed to be an irreversible outcome of advanced lepromatous leprosy.

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“…Epididymo-orchitis, scrotalgia and orchitis are common urological ailments. Testicular involvement by leprosy is quite common, incidence ranging from 23.6% to 68.3% [2,3]. India accounts for half of the leprosy burden of the world.…”

Section: Discussionmentioning

confidence: 99%

Chronic Epididymo-Orchitis Mimicking Tuberculosis Turned Out to be Leprosy: A Case Report

Arya¹

2020

AUN

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We report a 55-year male with a prior history of treatment for bilateral Epididymo-orchitis without relief. We thought of genitourinary tuberculosis (GUTB) or nonspecific Epididymo-orchitis as differentials. Suddenly he developed crops of lepromatous skin lesions. On reviewing the literature, we found the involvement of testes in leprosy in 60-90% of cases. However, urology literature and textbooks do not mention leprosy to be a differential diagnosis of orchitis or chronic Epididymo-orchitis. Therefore, testicular atrophy, infertility or chronic Epididymo-orchitis should make us consider the possibility of leprosy, considering the half of the global burden in India.

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The leprous testis

Cited by 7 publications

References 3 publications

Infertility and the provision of infertility medical services in developing countries

Infertility and the provision of infertility medical services in developing countries

Case Report: Successful Outcome of Primary Infertility with Multidrug Therapy in a Long-Standing Case of Hypogonadism Resulting from Lepromatous Leprosy: Shattering the Dogma of Irreversible Infertility in Leprosy

Chronic Epididymo-Orchitis Mimicking Tuberculosis Turned Out to be Leprosy: A Case Report

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