The lemon balm extract ALS-L1023 inhibits obesity and nonalcoholic fatty liver disease in female ovariectomized mice

Kim, Jeongjun; Lee, Hyunghee; Lim, Jonghoon; Lee, Haerim; Yoon, Sung-jun; Shin, Soon Shik; Yoon, Michung

doi:10.1016/j.fct.2017.05.059

Cited by 28 publications

(20 citation statements)

References 69 publications

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“…Interestingly, Fc‐apelin‐13 did not affect body weight, which is consistent with a recent report that AAV‐mediated apelin‐36 over‐expression does not modulate body weight gain in mice being fed with high fat diet . Obese mice fed with high‐fat‐diet develop steatosis and mild fibrosis in the liver . We have found that the Fc‐apelin‐13 treatment ameliorates hepatic steatosis by reducing triglyceride content and fibrosis.…”

Section: Discussionsupporting

confidence: 91%

“…42 Obese mice fed with high-fat-diet develop steatosis and mild fibrosis in the liver. [43][44][45] We have found that the Fc-apelin-13 treatment ameliorates hepatic steatosis by reducing triglyceride content and fibrosis. The mechanism is not clear and could be a consequence of improved insulin sensitivity or a direct effect of apelin on the liver through AMPK and PPARα signalling.…”

Section: Discussionmentioning

confidence: 97%

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Hepatic and cardiac beneficial effects of a long‐acting Fc‐apelin fusion protein in diet‐induced obese mice

Wang

Zhang

Yang

et al. 2018

Diabetes Metabolism Res

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 97%

Hepatic and cardiac beneficial effects of a long‐acting Fc‐apelin fusion protein in diet‐induced obese mice

Wang

Zhang

Yang

et al. 2018

Diabetes Metabolism Res

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“…Moreover, it has an antioxidant activity and protects against oxidative stress-induced apoptosis [12]. An ethyl acetate fraction of lemon balm extract has been shown to reduce high-fat-induced NAFLD in mice [13,14]. The main active compound of lemon balm is rosmarinic acid (RA, O-caffeoyl-3,4-dihydroxyphenyl lactic acid), which possesses a multitude of biological activities; the antioxidant, anti-inflammatory, anti-fatty liver, and anti-obesity effects [15][16][17].…”

Section: Of 15mentioning

confidence: 99%

Lemon Balm and Its Constituent, Rosmarinic Acid, Alleviate Liver Damage in an Animal Model of Nonalcoholic Steatohepatitis

et al. 2020

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Nonalcoholic fatty liver disease (NAFLD) ranges in severity from hepatic steatosis to cirrhosis. Lemon balm and its major constituent, rosmarinic acid (RA), effectively improve the liver injury and obesity; however, their therapeutic effects on nonalcoholic steatohepatitis (NASH) are unknown. In this study, we investigated the effects of RA and a lemon balm extract (LBE) on NAFLD and liver fibrosis and elucidated their mechanisms. Palmitic acid (PA)-exposed HepG2 cells and db/db mice fed a methionine- and choline-deficient (MCD) diet were utilized to exhibit symptoms of human NASH. LBE and RA treatments alleviated the oxidative stress by increasing antioxidant enzymes and modulated lipid metabolism-related gene expression by the activation of adenosine monophosphate-activated protein kinase (AMPK) in vitro and in vivo. LBE and RA treatments inhibited the expression of genes involved in hepatic fibrosis and inflammation in vitro and in vivo. Together, LBE and RA could improve liver damage by non-alcoholic lipid accumulation and may be promising medications to treat NASH.

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“…They also reported elevated mRNA levels of PPARα target enzymes of the liver, suggesting an increase in fatty acid catabolism which reduced hepatic intracellular and plasma levels of TG in addition to anti-angiogenic effects [44]. Additionally, in a recent study, properties of ALS mentioned above were confirmed along with alleviation of non-alcoholic fatty liver in female ovariectomized mice [49].…”

Section: Discussionmentioning

confidence: 90%

The effects of a Melissa officinalis L. based product on metabolic parameters in patients with type 2 diabetes mellitus: A randomized double-blinded controlled clinical trial

Nayebi

Esteghamati

Meysamie

et al. 2019

Journal of Complementary and Integrative Medicine

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Background Diabetic patients are at increased risk for coronary artery disease. Since phytotherapy has been greatly common, finding safe and effective treatments is of importance. This study aimed to evaluate the effects of a Melissa officinalis L. based product (MO) in patients with type 2 diabetes. Methods A randomized double-blinded controlled study was conducted with 37 dyslipidemic diabetic patients, assigned to either MO or placebo (P) groups receiving two 500 mg capsules daily for 3 months. Finally, 32 cases completed the study and were included in the analysis; MO (n=16) and P (n=16). Results Safe and significant effects in terms of decreasing the serum level of triglyceride (TG) in all patients after 2 months (p-value=0.02) and in patients with higher baseline serum levels of TG (TG≥200 mg/dl) after 3 months (p-value=0.04) were shown in the MO group. However, no metabolic significant changes were seen compared to the control group. Significant decrease in both systolic and diastolic blood pressure from baseline values were also found in patients with higher systolic blood pressure (SBP≥130 mmHg) (p-value=0.02) and those with higher diastolic blood pressure (DBP≥85 mmHg) (p-value=0.02) in the MO group. Conclusion This study showed that MO might be safe and beneficial in decreasing the serum TG level in dyslipidemic diabetic patients. Although, larger long-term studies are required.

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The lemon balm extract ALS-L1023 inhibits obesity and nonalcoholic fatty liver disease in female ovariectomized mice

Cited by 28 publications

References 69 publications

Hepatic and cardiac beneficial effects of a long‐acting Fc‐apelin fusion protein in diet‐induced obese mice

Hepatic and cardiac beneficial effects of a long‐acting Fc‐apelin fusion protein in diet‐induced obese mice

Lemon Balm and Its Constituent, Rosmarinic Acid, Alleviate Liver Damage in an Animal Model of Nonalcoholic Steatohepatitis

The effects of a Melissa officinalis L. based product on metabolic parameters in patients with type 2 diabetes mellitus: A randomized double-blinded controlled clinical trial

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