The Leishmania donovani peroxin 14 binding domain accommodates a high degeneracy in the pentapeptide motifs present on peroxin 5

Characterization of the interaction between Trypanosoma brucei Pex5p and its receptor Pex14p

“…However, a single motif mutation, such as first motif or third motif mutations, has no influence on interaction with Pex14p or localization in peroxisomal proteins . In the case of L. donovani , Jardim and colleagues have investigated the interaction of Ld Pex5p and Ld Pex14p extensively and reported that deletion of the third WXXXF/Y motif of Ld Pex5p abolished the Ld Pex5p‐ Ld Pex14p interaction . Recently, Hs Pex5p was shown to have a novel sequence, LVXEF in the NH 2 ‐teminal region that initiates binding to Hs Pex14p .…”

A Demographic and Epidemiological Investigation of Patients Afflicted with Cutaneous Leishmaniasis in The Diyala Government Region of Iraq

“…There are two morphological phases in the life cycle of these protozoa: the first phase included the elongated promastigotes with seen flagella that inhabit sandfly guts, while the second phase included the round-formed amastigotes without seen flagella that inhabit the mammalian cells [5]. During the infection, the metacyclic promastigotes are carried through the blood-sucking sandflies that mediate the transmission among mammalian hosts, in a few human cases, the hosts might also additionally stay asymptomatic for a long term, and therefore play a vital role in leishmaniasis transmission to their regions [6]. The insect vector leaves metacyclic promastigotes on its host's skin during the blood meal.…”