The Legionella collagen-like protein employs a distinct binding mechanism for the recognition of host glycosaminoglycans
Saima Rehman,
Anna Katarina Antonovic,
Ian E. McIntire
et al.
Abstract:Bacterial adhesion is a fundamental process which enables colonisation of niche environments and is key for infection. However, in Legionella pneumophila, the causative agent of Legionnaires’ disease, these processes are not well understood. The Legionella collagen-like protein (Lcl) is an extracellular peripheral membrane protein that recognises sulphated glycosaminoglycans on the surface of eukaryotic cells, but also stimulates bacterial aggregation in response to divalent cations. Here we report the crystal… Show more
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