The Leaf Essential Oil of<i>Momordica charantia</i>from Nigeria is Dominated by Geijerene and Pregeijerene

Owolabi, Moses S.; Omikorede, Oluwole; Yusuf, Kamil A.; Paudel, Prajwal; Setzer, William N.

doi:10.1080/0972060x.2013.813263

Cited by 2 publications

(2 citation statements)

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“…Furthermore, 3,10-Dihydro-1,4-dimethylazulene ( 95), a labile tri-nor-sesquiterpene biosynthetic precursor of 1,4-dimethylazulene (94), was first isolated from a cell culture of the liverwort Calypogeia granulata [239,272]. Its absolute stereochemistry was determined by the theoretical calculation of its circular dichroism spectra and verified by the synthesis of model compounds [273].…”

Section: Tri-nor-guaianes: 111213-tri-nor-guaianesmentioning

confidence: 99%

“…Similar to pregeijerene ( 2 ), compound 3 has also been isolated from many Pimpinella species [ 42 ] and exhibits antimicrobial and antioxidant activity [ 52 ]. It has also been found in Momordica charantia [ 94 ] and in the essential oil of Eupatorium odoratum Linn. leaves and was found to be active against E. coli and B. subtilis [ 95 ].…”

Section: Tri- Nor -Germacranes and Tri- ...mentioning

confidence: 99%

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Structures, Occurrences and Biosynthesis of 11,12,13-Tri-nor-Sesquiterpenes, an Intriguing Class of Bioactive Metabolites

Coca-Ruíz

Suárez

Aleu

et al. 2022

Plants

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The compounds 11,12,13-tri-nor-sesquiterpenes are degraded sesquiterpenoids which have lost the C3 unit of isopropyl or isopropenyl at C-7 of the sesquiterpene skeleton. The irregular C-backbone originates from the oxidative removal of a C3 side chain from the C15 sesquiterpene, which arises from farnesyl diphosphate (FDP). The C12-framework is generated, generally, in all families of sesquiterpenes by oxidative cleavage of the C3 substituent, with the simultaneous introduction of a double bond. This article reviews the isolation, biosynthesis and biological activity of this special class of sesquiterpenes, the 11,12,13-tri-nor-sesquiterpenes.

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Section: Tri-nor-guaianes: 111213-tri-nor-guaianesmentioning

confidence: 99%

Section: Tri- Nor -Germacranes and Tri- ...mentioning

confidence: 99%

Structures, Occurrences and Biosynthesis of 11,12,13-Tri-nor-Sesquiterpenes, an Intriguing Class of Bioactive Metabolites

Coca-Ruíz

Suárez

Aleu

et al. 2022

Plants

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In Vivo Treatment Efficacy of Essential Oil Isolated from Seeds of Momordica charantia in Streptozotocin-Induced Diabetes Mellitus

Grace

David

Jerrin

et al. 2021

BIOT

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Background: All parts of Momordica charantia L have potential hypoglycemic property in reversing the metabolic disorder of diabetes mellitus. But there exists a need for preparing an effective and safer formulation of active phytochemical. We have also reviewed certain patents on such preparatory methods for Momordica charantia L and analysis. Objective: The objectives were isolation of the essential oil from the seeds of Momordica charantia L, analysis of its phytochemicals and study of their anti-diabetic effects. Methods: The essential oil was isolated by hydro distillation method, analyzed for phytochemicals by GC-MS and tested its acute toxicity in rats. Anti-diabetic effects were evaluated in Streptozotocin induced diabetic rats with 17.5 and 55 mg/kg b.wt of essential oil by evaluating blood glucose, serum lipid profile, liver glycogen, protein and other serum markers such as ALT, AST, ALP, urea and creatinine. The histologic changes in the liver, pancreas and kidney were evaluated using Haematoxylin and Eosin staining. Results : The phytochemicals, having hypoglycaemic and insulin induction potency were identified in the GC-MS analysis. A highly significant (p≤0.01; p≤0.001) reduction in blood glucose was resulted for 17.5 mg/kg and 55 mg/kg essential oil treatments respectively. The diabetes associated metabolic alterations (p≤0.001) observed in diabetic control rats such as lipid profile, enzymes, glycogen, protein, urea and creatinine were normalized upon treatment with essential oil. The histologic changes in vital organs reversed in treated rats. Conclusion: The essential oil of Momordica charantia L. seed has promising potency to normalize the metabolic changes of type II diabetes mellitus.

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The Leaf Essential Oil ofMomordica charantiafrom Nigeria is Dominated by Geijerene and Pregeijerene

Cited by 2 publications

References 20 publications

Structures, Occurrences and Biosynthesis of 11,12,13-Tri-nor-Sesquiterpenes, an Intriguing Class of Bioactive Metabolites

Structures, Occurrences and Biosynthesis of 11,12,13-Tri-nor-Sesquiterpenes, an Intriguing Class of Bioactive Metabolites

In Vivo Treatment Efficacy of Essential Oil Isolated from Seeds of Momordica charantia in Streptozotocin-Induced Diabetes Mellitus

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