The Laugier–Hunziker syndrome

Abstract

Laugier and Hunziker described a syndrome consisting of asymptomatic benign areas of hyperpigmentation affecting the lips, buccal mucosa and, in 50%, the fingernails. We report a 67-year-old woman with the clinical features of Laugier-Hunziker syndrome in association with vulval pigmentation. Histology, immunohistochemistry and electron microscopy from the various areas of pigmentation on the body confirmed the benign nature of the pigmentation. We review potential causes of oral and genital pigmentation, and suggest an expansion of the original syndrome described by Laugier and Hunziker to include more widespread areas of benign hyperpigmentation, which may associated.

Laugier-Hunziker Syndrome: An Uncommon Cause of Oral Pigmentation and a Review of the Literature

“…The pathogenesis is unknown, but no systemic involvement or malignant predisposition has been described, so the correct clinical identification avoids the need for detailed and potentially hazardous investigations and treatment [3]. Few cases have been reported, and almost all have been published in the dermatological literature [4, 5]. Here we describe a patient with diffuse oral pigmentation associated with a toenail longitudinal pigmented band in which the diagnosis of Laugier-Hunziker pigmentation (Laugier-Hunziker syndrome) was made on the basis of clinical and histological findings.…”

A Pediatric Case of Pityriasis Rubra Pilaris Successfully Treated with Low-Dose Vitamin A

“…Administration of large amounts of vitamin A for treatment of PRP has been described in previous literature and textbooks [2, 3], but the effective amount and period of vitamin A has not been specifically described.…”

“…At the onset in infancy, we frequently hesitate to use these medications, which are etretinate, systemic corticosteroid, and biologics recommended by previous studies. An administration of high-dosage vitamin A was described in the previous textbook of dermatology [2]; however, it did not describe in detail the lower limits and the period. Herein, we present an infantile case of PRP which was hard to classify, successfully controlled with a minimal dose of systemic vitamin A in the long term.…”

A Case of Laugier-Hunziker Syndrome

“…Pigmentary change has also been reported on the fingertips and nail folds 7 . Pigmentation around the proximal nailfold has been termed the pseudoHutchinson's sign and no evidence of malignant changes has been reported 8 . The onset of this condition is usually in middle age and to date there has been no known association with systemic disease.…”