The Latin American Brain Health Institute, a regional initiative to reduce the scale and impact of dementia

Abstract

Latin American and Caribbean countries face complex challenges to improve brain health and reduce the impact of dementia. Regional hubs devoted to research, capacity building, implementation science, and education are critically needed. The Latin American Brain Health Institute represent an important step to address many of these needs. K E Y W O R D Sbrain health, capacity building, dementia, Latin America, networking, translational research Latin America and the Caribbean countries (LACs) urgently require the development of harmonized, innovative, multisectoral, educational, and regional centers focused on brain health and dementia research. 1

Classification of Alzheimer's disease and frontotemporal dementia using routine clinical and cognitive measures across multicentric underrepresented samples: a cross sectional observational study

“… 5 , 39 The data-driven techniques employed here provide a reliable approach to accurately discriminate between conditions, in a region known for exhibiting high clinical heterogeneity, having no systematic procedures for clinical assessment of dementia, and presenting limited access to biomarkers. 1 , 8 , 10 , 40 - 43 Additionally, the results add new evidence supporting complementary automatized methods for clinical discrimination of dementia. Such methods highlight the discriminative potential of measures of executive functioning, neuropsychiatric symptoms, and social cognition as compared to classical cognitive measures.…”

Genuine high-order interactions in brain networks and neurodegeneration

“…The study comprised a total of 173 participants, including 99 healthy controls (CN), 25 bvFTD, and 49 CE patients from an ongoing analytical framework of multimodal neuroimaging (Birba et al, 2022;Díaz-Rivera et al, 2022;Legaz et al, 2021;Salamone et al, 2021) led by BrainLat (Duran-Aniotz et al, 2022) and including resting-state electroencephalography (EEG) and f/MRI recordings. For the CN group, 95 patients were recorded using fMRI, 46 EEG, and 42 using both.…”

A cost-benefit framework for prosocial motivation – advantages and challenges

“…This not only will help to combat global challenges, but will also prove whether the knowledge we have accumulated in our discipline makes sense in the wild (68). Diversifying our samples and creating knowledge from countries in the Big South might be crucial to achieve these goals (69,70). Understanding prosocial behaviour could potentially have a positive impact on the lives of many people across the world, and this cost-benefit framework might be an important contributor to this end.…”