The latex fixation test in rheumatic diseases

Singer, Jacques M.

doi:10.1016/0002-9343(61)90161-9

Cited by 93 publications

(28 citation statements)

References 85 publications

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“…RF are observed in about 30% of patients but are not speci®c for SLE [3]. In previous studies examining the relevance of RF in SLE, controversial conclusions have been drawn with regard to lupus nephritis.…”

Section: Discussionmentioning

confidence: 99%

“…However, they have also been observed in a variety of other conditions and in up to 5% of normal blood donors [2]. Approximately one third of patients suering from systemic lupus erythematosus (SLE) also display RF [3,4]. Previous reports have suggested that the presence of RF is associated with clinical subgroups of SLE patients, namely those who suer more often from skin rash and sicca syndrome [5].…”

Section: Introductionmentioning

confidence: 99%

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Rheumatoid factors in systemic lupus erythematosus: association with clinical and laboratory parameters

Witte¹,

Hartung

Sachse

et al. 2000

Rheumatology International

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The prevalence and clinical and laboratory associations of IgM, IgG and IgA rheumatoid factors (RF) were determined in 352 patients with systemic lupus erythematosus (SLE). IgM, IgG, and IgA class RF were detected in 17.9%, 20.5%, and 20.5% of the sera, respectively. RF were associated with sicca syndrome, hypergammaglobulinemia, high titer of antinuclear antibodies, anemia, SSA- and SSB-antibodies, and with the presence of HLA-DR3. RF correlated negatively with nephritis and livedo racemosa. Moreover, we observed an association of RF and parameters of inflammatory activity such as elevated erythrocyte sedimentation rate (ESR) and leukopenia. Analysis of immunoglobulin classes revealed that laboratory parameters of inflammatory activity, SSA- and SSB-antibodies and HLA-DR3 correlated with IgA RF only. IgA RF define a subgroup of SLE patients characterized by distinct autoimmune phenomena and high disease activity in the absence of nephritis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rheumatoid factors in systemic lupus erythematosus: association with clinical and laboratory parameters

Witte¹,

Hartung

Sachse

et al. 2000

Rheumatology International

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“…A more detailed description of the ability of the LAT to detect the rheumatoid factor was presented by Singer (1961). He reported that a standardized latex particle suspension which had a total surface area of 9.2 cm2 could absorb 1.46 yg of human gamma globulin nitrogen per ml.…”

Section: Latex Agglutination Testmentioning

confidence: 99%

Adaptation of a latex agglutination tube test for diagnosis of Mycoplasma hyopneumoniae swine pneumonia

Slavik

Switzer

1979

Veterinary Microbiology

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“…[1][2][3][4][5][6] Recently, there has been considerable interest in the development of polymer particles by dispersion polymerization, mainly due to the spherical shape and the highly monodisperse size distribution of product particles. The variety of these monodisperse micron-sized polymer particles has expanded into many areas of specialty applications such as medical diagnostics, [7,8] liquid chromatography, [9,10] enzyme immobilization, [11,12] and drug delivery. [13] However, the common results of the crosslinking of polymer particles by a conventional dispersion polymerization have been broad size distributions, odd-shaped particles, and particle coagula.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Monodisperse Crosslinked Organic‐Inorganic Hybrid Copolymer Particles by Dispersion Polymerization

Jun

Hong

Park

et al. 2003

Macro Chemistry & Physics

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This study presents a new method for producing monodisperse crosslinked organic‐inorganic hybrid polymer particles in micron‐size by using simple dispersion polymerization. Firstly, highly monodisperse hybrid copolymer particles were prepared by conventional dispersion polymerization of styrene and 3‐(trimethoxysilyl)propyl methacrylate (TMSPM) in a methanol/water medium. It was very interesting to find that slightly crosslinked hybrid polymer particles were formed by this simple dispersion polymerization due to a partial condensation reaction between the adjacent silanol groups of the TMSPM during the polymerization. Secondly, for the hydrolytic condensation of the remaining trimethoxysilyl groups, post treatment by sol‐gel process was carried out to form an inorganic siloxane network, which provides the particle with high crosslinking density. In the proper conditions, monodisperse crosslinked particles could be produced in high TMSPM concentrations, up to 20 wt.‐%. In addition, the size monodispersity of the hybrid polymer particles was maintained after the sol‐gel process. Crosslinking with inorganic networks formed by the sol‐gel process was confirmed by a thermal analysis and a 29Si NMR spectroscopy.Synthesis of crosslinked organic‐inorganic hybrid polymer particles by dispersion copolymerization and post sol‐gel process.magnified imageSynthesis of crosslinked organic‐inorganic hybrid polymer particles by dispersion copolymerization and post sol‐gel process.

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The latex fixation test in rheumatic diseases

Cited by 93 publications

References 85 publications

Rheumatoid factors in systemic lupus erythematosus: association with clinical and laboratory parameters

Rheumatoid factors in systemic lupus erythematosus: association with clinical and laboratory parameters

Adaptation of a latex agglutination tube test for diagnosis of Mycoplasma hyopneumoniae swine pneumonia

Preparation of Monodisperse Crosslinked Organic‐Inorganic Hybrid Copolymer Particles by Dispersion Polymerization

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