The latest research trends in primary biliary cholangitis: a bibliometric analysis

Abstract

Background and aims: The bibliometric analysis uses the citation count of an article to measure its impact in the scienti c community, but no study has been undertaken to determine the most in uential papers in the eld of primary biliary cholangitis (PBC). This study aimed to investigate the global research interest regarding PBC in dentistry using a bibliometric approach. Methods: We searched the Web of Science Core Collection database to nd the top 100 most cited (T100) articles focusing on PBC. The information about each article including citations, authors, journals, countries, institutions, and keywords was recorded for bibliometric analysis. Results: The T100 articles related to PBC were published from 1983 to 2019 and were originated from 26 countries. A total of 805 different authors were from 342 different institutions, and articles written by them were published in 35 journals. The ve most frequently occurring keywords were "biochemical response", "ursodeoxycholic acid", "primary biliary cirrhosis", "antimitochondrial antibody", and "autoimmunity". The T100 articles were classi ed into different research focuses: pathogenesis (41%), treatment (20%), prognosis (12%), epidemiology (9%), diagnosis (8%) and others (10%). These 100 articles included 32 observational studies, 29 basic research articles, 15 reviews, eight meta-analyses, 12 clinical trials, and four clinical guidelines. Conclusions: This report presents major advances and changes in research regarding PBC. The single treatment method entered a bottleneck period, and combined treatment with immunosuppressant, local therapy, and surgery will become the next research focus to identify possible bene cial treatment combinations.

Primary Biliary Cholangitis, Liver Transplantation, and Hepatocellular Carcinoma: A Mini-review

“…The familial risk of PBC for women with one affected first-degree relative is higher than for women with no affected relatives. 1 Furthermore, the risk of PBC was found to be higher with an increasing degree of familial relationships. 19 Growing evidence has suggested that environmental factors, in combination with genetic predisposition, play an essential role in disease development.…”

“…8 PBC prevalence has also been increasing over time. 1 In Northern England, between 1987 and 1994, prevalence increased from 20 to 33 cases per 100,000 adults, and from 54 to 94 cases per 100,000 women over the age of 40. 9 In Australia, prevalence increased from 1 to 5.1 cases per 100,000 between 1991 and 2004, 10 while in Canada, prevalence increased from 10 to 22.7 cases per 100,000 between 2002 and 2009.…”

“…17 Hereditary susceptibility is a crucial contributing element in the pathogenesis of PBC. 1 Genetic predisposition is supported by significant concordance in monozygotic twins. The familial risk of PBC for women with one affected first-degree relative is higher than for women with no affected relatives.…”

“…Primary biliary cholangitis (PBC) is a chronic autoimmune disease characterized by T-lymphocyte mediated destruction of intrahepatic biliary epithelial cells and a distinctive serologic marker, antimitochondrial antibody (AMA). 1 Histologically, PBC is characterized by infiltration of mononuclear cells and destruction of intrahepatic small bile ducts, followed by liver cirrhosis and, eventually, liver failure. 2 PBC predominantly affects middle-aged women, and the rate of disease progression differs significantly between patients.…”

Autoimmune pancreatitis: A bibliometric analysis from 2002 to 2022

“…Bibliometric analysis enables the qualitative and quantitative profiling of publications (4) and allows researchers to identify not only the productive countries/regions, institutions, and authors but also the research focus and emerging topics within a specific field (5,6). Additionally, bibliometric analysis has been applied in research on autoimmune digestive diseases, including inflammatory bowel disease and primary biliary cholangitis (7,8). However, a bibliometric analysis of AIP has not been reported in the literature thus far.…”