The Latest Evidence from Vitamin D Intervention Trials for Skeletal and Non-skeletal Outcomes

Sami, A; Abrahamsen, Bo

doi:10.1007/s00223-019-00616-y

Cited by 5 publications

(4 citation statements)

References 20 publications

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“… 9 , 10 Beyond its traditional role in bone health, vitamin D exerts significant effects on gene regulation, cardiovascular function, immune response, and hormonal interplay through the vitamin D receptor. 11 , 12 , 13 Vitamin D deficiency affects a substantial portion of the global population and has been implicated in various disorders where serotonin dysregulation is involved. 14 , 15 …”

Section: Introductionmentioning

confidence: 99%

Does vitamin D supplementation impact serotonin levels? A systematic review and meta‐analysis

Alimohammadi‐Kamalabadi,

Ziaei,

Hasani

et al. 2024

Health Science Reports

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Background and AimsVitamin D deficiency impacts a significant proportion of the world's population, and this deficiency has been linked to various conditions characterized by imbalanced serotonin regulation. The objective of this systematic review and meta‐analysis was to evaluate the effect of vitamin D supplementation on serum serotonin levels.MethodsWe conducted a comprehensive search of PubMed, Scopus, Cochrane Central for Randomized Clinical Trials, and Web of Science up to September 2022, without any language restrictions. The effect sizes were calculated using the standard mean difference (SMD) and 95% confidence interval (CI).ResultsSix randomized clinical trials involving 356 participants were included in the analysis. Our findings indicated no significant changes in serotonin levels between the intervention and control groups (SMD: 0.24 ng/mL, 95% CI: −0.28, 0.75, p > 0.10). Subgroup analysis also did not reveal any significant changes in serotonin levels among children, participants with autism spectrum disorders, interventions lasting 10 weeks or longer, or those receiving vitamin D doses below 4000 IU/day.ConclusionAlthough the results obtained in this systematic review are inconclusive, they support the need for further well‐designed randomized trials to assess the potential role of vitamin D supplementation in regulating serotonin levels and potentially ameliorating depression and related disorders.

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Section: Introductionmentioning

confidence: 99%

Does vitamin D supplementation impact serotonin levels? A systematic review and meta‐analysis

Alimohammadi‐Kamalabadi,

Ziaei,

Hasani

et al. 2024

Health Science Reports

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“…Vitamin D is of crucial importance for bone health, and it appears to have extra-skeletal influences. 1,2 Vitamin D can be procured from solar ultraviolet B radiation (wavelength 290-315 nm), the diet, or dietary supplements. 3 The two major varieties of vitamin D (calciferol) are the plant form referred to as vitamin D2 (ergocalciferol) and the animal form known as vitamin D3 (cholecalciferol).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, carriers of the "A" allele of CYP2R1 rs10741657 have upsurges of 25(OH)D concentrations following interferon-α therapies. In addition to 25(OH)D suppressing HCV replication, the biologically active vitamin D metabolite 1,25dihydroxyvitamin D 3(1,25[OH] 2 D 3 ) directly suppresses HCV-RNA replication. Furthermore, antiviral vitamin D-vitamin D receptor (VDR) signaling in peripheral blood mononuclear cells (PBMCs) is activated to improve the response to interferon-based therapy.…”

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confidence: 99%

Relationships Between Vitamin D Status and Cytokine: Results from Interferon-Based Therapy in Non-Cirrhotic, Treatment-Naïve Patients with Chronic Hepatitis C Infection

Chen

Chiu

Hsieh

et al. 2020

JIR

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Background: Vitamin D contributes to bone health and extra-skeletal effects. The mechanisms underlying vitamin D metabolism have not been extensively evaluated. The relationships between vitamin D and inflammatory cytokines are debated. Our objective was to investigate whether supplemental interferons are associated with longitudinal change of vitamin D status in humans. Methods: A total of 48 patients with 24 or 48 weeks of pegylated interferon-α plus ribavirin therapy were examined for serum 25-hydroxyvitamin D (25[OH]D) level before treatment, at the end of treatment, and 24 weeks after treatment. In addition, we analyzed publicly available RNA sequencing data from accession GSE42697 and GSE7123 in the Gene Expression Omnibus. Findings: The overall sustained virologic response (SVR) rate was 62.5%. There was no statistically significant association between baseline 25(OH)D concentrations and liver fibrosis. In patients with SVR, serum 25(OH)D increased markedly at end-of-treatment and decreased markedly by the end of the 24-week follow-up period. In the non-SVR group, this treatment-dependent change was lost. In gene expression analysis, the vitamin D biosynthesis process was activated in subjects with SVR, but not in patients without SVR. Furthermore, vitamin D receptor (VDR) signaling in peripheral blood mononuclear cells (PBMCs) was triggered in marked responders but not in poor responders. Conclusion:In the aggregate, these data suggest that interferons have a regulatory influence on vitamin D status that can contribute to VDR signaling in PBMCs.

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“…In vitamin D research, as elsewhere, no sooner have manuscripts been accepted for publication than the latest (sometimes contradictory) evidence is published. With large studies and meta-analyses, recruiting ever more diverse populations and looking at variable outcome measures, we are grateful to Dr Sami and Professor Abrahamsen for their attempts to keep us up to date [15]. They note a change in focus of vitamin D research.…”

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confidence: 99%

Vitamin D in Musculoskeletal Health and Beyond

Aspray

2020

Calcif Tissue Int

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The Latest Evidence from Vitamin D Intervention Trials for Skeletal and Non-skeletal Outcomes

Cited by 5 publications

References 20 publications

Does vitamin D supplementation impact serotonin levels? A systematic review and meta‐analysis

Does vitamin D supplementation impact serotonin levels? A systematic review and meta‐analysis

Relationships Between Vitamin D Status and Cytokine: Results from Interferon-Based Therapy in Non-Cirrhotic, Treatment-Naïve Patients with Chronic Hepatitis C Infection

Vitamin D in Musculoskeletal Health and Beyond

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