The latest advances in the pharmacological management of endometriosis

Hartner, Gabriel; Husslein, H; Kuessel, Lorenz; Gstoettner, Manuela; Tiringer, Denise; Wenzl, René; Perricos, Alexandra

doi:10.1080/14656566.2022.2045274

Cited by 5 publications

(3 citation statements)

References 76 publications

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“…Future research should focus on developing new medications with increased efficacy, improved safety profiles, and minimal contraceptive effects. Additionally, exploring alternative treatment modalities such as oral gonadotropin receptor antagonists, selective progesterone receptor modulators, and angiogenesis inhibitors may prove advantageous [160] . Understanding the pathogenesis: The exact cause and underlying mechanisms of endometriosis are still not fully understood.…”

Section: Research Gaps and Areas For Further Investigationmentioning

confidence: 99%

“…However, there are several research gaps in the diagnosis and management of endometriosis. Future studies should focus on improving diagnostic methods, developing personalized treatment approaches, exploring novel therapeutic options, and further understanding the pathogenesis of the disease [141,157,159,160] .…”

Section: Research Gaps and Areas For Further Investigationmentioning

confidence: 99%

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Advances in the Diagnosis and Management of Endometriosis: A Comprehensive Review

Chen,

Waseem,

Luo

2024

Preprint

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Endometriosis is a common gynecological condition characterized by the presence of endometrial-like tissue outside the uterus, leading to chronic pelvic pain and infertility. This review aims to provide an overview of recent advances in the diagnosis and management of endometriosis. The article discusses the pathogenesis, clinical presentation, diagnostic modalities, and treatment options for endometriosis. Additionally, it highlights emerging technologies and novel therapeutic approaches that show promise in improving patient outcomes. By summarizing the current state of knowledge, this review aims to guide clinicians in providing optimal care for patients with endometriosis.

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Section: Research Gaps and Areas For Further Investigationmentioning

confidence: 99%

Section: Research Gaps and Areas For Further Investigationmentioning

confidence: 99%

Advances in the Diagnosis and Management of Endometriosis: A Comprehensive Review

Chen,

Waseem,

Luo

2024

Preprint

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“…Current first- and second-line medical treatments available for endometriosis-related pain include nonsteroidal anti-inflammatory drugs, hormonal therapies (such as oral contraceptives), gonadotropin-releasing hormone (GnRH) agonists, and, more recently, GnRH antagonists ( 15 , 16 , 17 , 18 ). However, GnRH agonists and antagonists are not always effective and may be associated with hypoestrogenic side effects, such as hot flashes, decreased bone mineral density, and depression ( 8 , 18 , 19 ). In patients whose symptoms are refractory to pharmacologic treatment, surgical treatment options may be advised; however, these are also not always effective and may be associated with symptom recurrence and surgical complications ( 12 , 14 , 20 ).…”

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confidence: 99%

Vilaprisan for the treatment of symptomatic endometriosis: results from a terminated phase 2b randomized controlled trial

Taylor,

Dong,

Haikonen

et al. 2024

F&S Reports

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Novel pharmacological therapies for the treatment of endometriosis

Buggio

Dridi

Barbara

et al. 2022

Expert Review of Clinical Pharmacology

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Introduction:Endometriosis is a chronic, estrogen-dependent, inflammatory disease associated with pelvic pain, infertility, impaired sexual function, and psychological suffering. Therefore, tailored patient management appears of primary importance to address specific issues and identify the appropriate treatment for each woman. Over the years, abundant research has been carried out with the objective to find new therapeutic approaches for this multifaceted disease.Areas covered: This narrative review aims to present the latest advances in the pharmacological management of endometriosis. In particular, the potential role of GnRH antagonists, selective progesterone receptor modulators (SPRMs), and selective estrogen receptors modulators (SERMs) will be discussed. We performed a literature search in PubMed and Embase, and selected the best quality evidence, giving preference to the most recent and definitive original articles and reviews.Expert opinion: Medical therapy represents the cornerstone of endometriosis management, although few advances have been made in the last decade. Most studies have focused on the evaluation of the efficacy and safety of GnRH antagonists (plus add-back therapy in cases of prolonged treatment), which should be used as second-line treatment options in selected cases (i.e. non-responders to first-line treatments). Further studies are needed to identify the ideal treatment for women with endometriosis.

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The latest advances in the pharmacological management of endometriosis

Cited by 5 publications

References 76 publications

Advances in the Diagnosis and Management of Endometriosis: A Comprehensive Review

Advances in the Diagnosis and Management of Endometriosis: A Comprehensive Review

Vilaprisan for the treatment of symptomatic endometriosis: results from a terminated phase 2b randomized controlled trial

Novel pharmacological therapies for the treatment of endometriosis

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