Background: The purpose of this study was to determine the factors associated with outcomes after reverse total shoulder arthroplasty (RTSA). Methods: We retrospectively evaluated all RTSAs performed by the senior author between January 1, 2007, and November 1, 2017. We evaluated pain visual analog scale (VAS), Simple Shoulder Test (SST), and American Shoulder and Elbow Surgeons Standardized Shoulder Assessment Form (ASES) scores and complication and reoperation rates at a minimum of 2-year follow-up. We evaluated preoperative and 2-week postoperative radiographs for glenoid inclination (GI), medialization as distance between the center of the humeral head or glenosphere and the line of the deltoid, and distalization via the acromial-greater tuberosity distance. We performed inter-and intrarater reliabilities via intraclass correlation coefficients (ICCs) and conducted a multivariable analysis. Results: We included 230 RTSAs in the analysis, with 70% follow-up at a median of 3.4 years. Reliability was acceptable with all ICCs >.678. Increased postoperative GI was significantly associated with increased VAS pain postoperatively (P ¼ .008). Increased distalization was associated with an increased rate of complications and reoperations (P ¼ .032). Younger age (P ¼ .008), female gender (P ¼ .009), and lower body mass index (BMI) (P ¼.006) were associated with worse ASES scores. Female gender (P <.001) and lower BMI (P ¼.039) were associated with worse SST scores. Female gender (P ¼ .013) and lower BMI (P ¼ .005) were associated with worse VAS-pain scores. Conclusion: Age, gender, and BMI are associated with outcome after RTSA. In this retrospective analysis of a Grammont-style RTSA, superior inclination is associated with increased pain postoperatively, whereas excessive arm lengthening is associated with increased risk for complication or reoperation.