The lateral, third, and fourth ventricle choroid plexus of the dog: A structural and ultrastructural study

Gomez, Daniel G.; Potts, D. Gordon

doi:10.1002/ana.410100404

Cited by 38 publications

(29 citation statements)

References 24 publications

(19 reference statements)

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“…In general, SEM and TEM analyses of the CPs from buffalo brain showed morphological and structural features similar to those reported in other mammalian species (Adami et al, 2005;De Spiegelaere et al, 2008;Gomez and Potts, 1981;Miodonski et al, 1979;Peters and Swan, 1979;Rajtovà , 2002;Scala et al, 1994;Tamega et al, 2000;Webster, 1976). The blood microvasculature is the major component of the CPs responsible for the formation of the CSF.…”

Section: Discussionsupporting

confidence: 54%

Microvasculature of the buffalo (Bubalus bubalis) choroid plexuses: Structural, histochemical, and immunocytochemical study

Scala

Corona

Langella

et al. 2010

Microscopy Res & Technique

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The choroid plexuses (CPs) in mammals produce the cerebrospinal fluid (CSF). In the literature, the morphology of CPs and the process that regulates the production of CSF are virtually nonexistent for domestic ruminants. Thus this study has two aims: 1. to investigate the morpho-structure of the buffalo CP microvasculature utilizing light microscopy (LM), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) techniques, and 2. to investigate the relationship between the blood vessels and both the elongated cells and the cells with multiple protrusions located in the CPs. SEM and TEM analyses of the CPs from buffalo brain showed morphological and structural features similar those reported in other mammalian species. Moreover the blood microvasculature is the major component responsible for the formation of the CSF, secreted by the encephalic CPs. In addition the chemical composition of this fluid depends on several morpho-functional characteristics of the vascularization of the CPs. These characteristics are as follows: two shapes of the vascular organization: lamina-like and ovoid-like elongated cells of the CPs, which connect the ventricular cavities to the blood capillaries; and the CP capillaries have diverse forms. In the present study the employment of NADPHd and NOS I was taken as indirect evidence for the presence of NO for investigation their specific role in CPs. Then NOS I immunoreactivity is found in the walls of CP blood vessels demonstrating indirectly the presence of NO with a vaso-dilatatory and autoregulation function of vascular tone by cholinergic nerve stimulation of blood vessel smooth muscle.

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Section: Discussionsupporting

confidence: 54%

Microvasculature of the buffalo (Bubalus bubalis) choroid plexuses: Structural, histochemical, and immunocytochemical study

Scala

Corona

Langella

et al. 2010

Microscopy Res & Technique

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“…The actual structure of the choroid plexus epithelium itself, with high vascularisation and increased size of the plexus capillaries (up to 15 μm) compared with other brain capillaries (approximately 2 μm [37,38]) suggests cellular activity.…”

Section: Reviewmentioning

confidence: 99%

Fluids and barriers of the CNS: a historical viewpoint

Liddelow

2011

Fluids Barriers CNS

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Tracing the exact origins of modern science can be a difficult but rewarding pursuit. It is possible for the astute reader to follow the background of any subject through the many important surviving texts from the classical and ancient world. While empirical investigations have been described by many since the time of Aristotle and scientific methods have been employed since the Middle Ages, the beginnings of modern science are generally accepted to have originated during the 'scientific revolution' of the 16th and 17th centuries in Europe. The scientific method is so fundamental to modern science that some philosophers consider earlier investigations as 'pre-science'. Notwithstanding this, the insight that can be gained from the study of the beginnings of a subject can prove important in the understanding of work more recently completed. As this journal undergoes an expansion in focus and nomenclature from cerebrospinal fluid (CSF) into all barriers of the central nervous system (CNS), this review traces the history of both the blood-CSF and blood-brain barriers from as early as it was possible to find references, to the time when modern concepts were established at the beginning of the 20th century.

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“…This was important because the opossum, unlike eutherian mammals, does not seem to have a period when the choroidal epithelial cells store large amounts of glycogen ). The choroid plexus in each brain ventricle was examined because there have been very few studies that have compared the ultrastructure of the different choroid plexuses during development (Gomez and Potts, 1981).…”

mentioning

confidence: 99%

Structural characteristics and barrier properties of the choroid plexuses in developing brain of the opossum (Monodelphis Domestica)

Habgood

Dzięgielewska

et al. 2003

J of Comparative Neurology

116

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The structural and functional development of the choroid plexuses, the site of the blood-cerebrospinal fluid (CSF) barrier, in an opossum (Monodelphis domestica) was studied. Marsupial species are extremely immature at birth compared with more conventional eutherian species. Choroid plexus tissue of each brain ventricle, from early stages of development, was collected for light and electron microscopy. During development, the choroidal epithelium changes from a pseudostratified to a cuboidal layer. Individual epithelial cells appear to go through a similar maturation process even though the timing is different between and within each plexus. The ultrastructural changes during development in the choroidal epithelial cells consist of an increase in the number of mitochondria and microvilli, and changes in structure of endoplasmic reticulum. There are also changes in the core of plexuses with age. In contrast, the structure of the tight junctions between epithelial cells does not appear to change with maturation. In addition, the route of penetration for lipid insoluble molecules from blood to CSF across the choroid plexuses was examined using a small biotin-dextran. This showed that the tight junctions already form a functional barrier in early development by preventing the paracellular movement of the tracer. Intracellular staining shows that there may be a transcellular route for these molecules through the epithelial cells from blood to CSF. Apart from lacking a glycogen-rich stage, cellular changes in the developing opossum plexus seem to be similar to those in other species, demonstrating that this is a good model for studies of mammalian choroid plexus development.

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The lateral, third, and fourth ventricle choroid plexus of the dog: A structural and ultrastructural study

Cited by 38 publications

References 24 publications

Microvasculature of the buffalo (Bubalus bubalis) choroid plexuses: Structural, histochemical, and immunocytochemical study

Microvasculature of the buffalo (Bubalus bubalis) choroid plexuses: Structural, histochemical, and immunocytochemical study

Fluids and barriers of the CNS: a historical viewpoint

Structural characteristics and barrier properties of the choroid plexuses in developing brain of the opossum (Monodelphis Domestica)

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