The Latent Interval for Thyroid Cancer Following Irradiation

Raventos, A.; Winship, Theodore

doi:10.1148/83.3.501

Cited by 44 publications

(12 citation statements)

References 17 publications

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“…Dolphin et al 29 and Raventos et al 30 found that after external irradiation in childhood, cumulative frequency of thyroid cancer showed a rapid increase and a plateau 15 to 25 years after exposure. The latent period for radiation-induced thyroid neoplasms may be longer than 30 years, and cases of thyroid cancers have been reported as long as 40 years after irradiation.…”

Section: Basic Information About Radiation Exposurementioning

confidence: 99%

Radiation Exposure to the Surgeon During Fluoroscopically Assisted Percutaneous Vertebroplasty

Harstall¹,

Heini²,

Mini³

et al. 2005

Spine

115

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Section: Basic Information About Radiation Exposurementioning

confidence: 99%

Radiation Exposure to the Surgeon During Fluoroscopically Assisted Percutaneous Vertebroplasty

Harstall¹,

Heini²,

Mini³

et al. 2005

Spine

115

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“…Radiogenic thyroid cancer from nonoccupational exposure to radioactive iodine or external penetrating radiation is well established. (29) Rudimentary epidemiologic considerations regarding the latency of brain and thyroid tumors (30,31) pointed to the 1960s and the 1970s as eras of interest for investigation of historical emissions.…”

Section: Hypothesismentioning

confidence: 99%

Environmental Surveillance at Los Alamos: An Independent Reassessment of Historical Data

Silver¹,

Clapp²

2006

Risk Analysis

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Since 1971, a series of annual Environmental Surveillance ... reports have served as the official public record of Los Alamos National Laboratory's (LANL) environmental performance. In northern New Mexico, where past LANL emissions are a public health concern, there is public skepticism over the accuracy of information contained in these reports. To test the hypothesis that LANL Environmental Surveillance ... reports systematically understate past emissions, we compared the data on releases in LANL's own internal Occurrence Reports Collection (ORC) to the data reported to the public in the Environmental Surveillance ... reports. A data set of 89 environmental occurrences recorded in the ORC in the time period from 1971 through 1980 was assembled. We did not find a systematic pattern of quantitative underreporting of source terms. However, 17 of the 89 (19%) environmental occurrences recorded in the ORC were not reported to the public in the Environmental Surveillance ... reports. The observed discrepancies are discussed in terms of their relevance to public health concerns. Methodological caveats dictate restraint in applying these findings beyond the scope of the relative comparison performed here. Possible social origins for the rejected hypothesis are discussed. Areas for further consideration by the Centers for Disease Control's dose reconstruction study of LANL are identified.

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“…More recently, a number of studies have confirmed the relationship between lowdose thyroid irradiation exposure and the increased incidence of thyroid neoplastic disease, both benign and Several large recall studies of children who received neck irradiation have demonstrated an incidence of benign thyroid nodules ranging from 10% to 30% and an increased incidence of carcinoma of the thyroid.2,2'*22 The reported latent period between radiation exposure and thyroid neoplasms ranged from 3 to 30 years, with a median of about i 1 years, corresponding to the data in this series. 23 DeLawter and Winship reviewed a series of 222 adult patients treated with therapeutic neck irradiation for cancer and hyperthyroid disease but were not able to demonstrate an increased incidence of thyroid malignancy. However, among the children treated with irradiation, there was an increase in thyroid ne~plasia.…”

Section: Thyroid Neoplasiamentioning

confidence: 99%

Thyroid dysfunction and neoplasia in children receiving neck irradiation for cancer

Fleming

Black

Thompson

et al. 1985

Cancer

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The reported relationship of radiation exposure and thyroid carcinoma stimulated this retrospective study of 298 patients treated at St. Jude Children's Hospital with radiation therapy to the neck for childhood cancer to identify patients who developed subsequent thyroid abnormalities. This series includes 153 patients with Hodgkin's disease, 95 with acute lymphocytic leukemia, 28 with lymphoepi‐thelioma, and 22 with miscellaneous tumors. Inclusion in the study required 5 years of disease‐free survival following therapy for their original tumor, which included thyroid irradiation. Follow‐up has been 100%. Most patients also received chemotherapy. Seventeen patients were found to have decreased thyroid reserve with normal levels of free triiodothyroxine (T3) or free thyroxin, (T4) and an elevated level of thyroid‐stimulating hormone (TSH). In nine patients hypothyroidism developed, with decreased T3 or T4 levels and an elevated level of TSH. One hyperthyroid patient was identified. Two patients had thyroiditis, and seven had thyroid neoplasms: (carcinoma in two, adenoma in two, colloid nodule in one, and undiagnosed nodules in two). This survey has demonstrated an increased incidence of thyroid dysfunction and thyroid neoplasia when compared to the general population. The importance of long‐term follow‐up for thyroid disease is emphasized in patients who have received thyroid irradiation. The possible role of subclinical hypothyroidism with TSH elevation coupled with radiation darnage to the thyroid gland as a model for the development of neoplastic disease is discussed. Cancer 55:1190‐1194, 1985.

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The Latent Interval for Thyroid Cancer Following Irradiation

Cited by 44 publications

References 17 publications

Radiation Exposure to the Surgeon During Fluoroscopically Assisted Percutaneous Vertebroplasty

Radiation Exposure to the Surgeon During Fluoroscopically Assisted Percutaneous Vertebroplasty

Environmental Surveillance at Los Alamos: An Independent Reassessment of Historical Data

Thyroid dysfunction and neoplasia in children receiving neck irradiation for cancer

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