The Last Voyage of Drake and Hawkins

Andrews, Kenneth R.

doi:10.4324/9781315556321

Cited by 7 publications

(3 citation statements)

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“…However, further studies are required to decipher the molecule mechanism controlling this inhibitory LAG3-MHC class II signaling pathway. LAG-3 is a CD4-like molecule that binds MHC class with a greater affinity than CD4 (Andrews et al, 2017). Whereas CD4 binds MHC class II interaction in the presence of antigen, whether LAG-3 binding to MHC class II required antigen presentation remain elusive.…”

Section: Discussionmentioning

confidence: 99%

LAG3+ Regulatory T Cells Restrain Interleukin-23-Producing CX3CR1+ Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis

et al. 2018

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Interleukin-22 (IL-22)-producing group 3 innate lymphoid cells (ILC3) maintains gut homeostasis but can also promote inflammatory bowel disease (IBD). The regulation of ILC3-dependent colitis remains to be elucidated. Here we show that Foxp3 regulatory T cells (Treg cells) prevented ILC3-mediated colitis in an IL-10-independent manner. Treg cells inhibited IL-23 and IL-1β production from intestinal-resident CX3CR1 macrophages but not CD103 dendritic cells. Moreover, Treg cells restrained ILC3 production of IL-22 through suppression of CX3CR1 macrophage production of IL-23 and IL-1β. This suppression was contact dependent and was mediated by latent activation gene-3 (LAG-3)-an immune checkpoint receptor-expressed on Treg cells. Engagement of LAG-3 on MHC class II drove profound immunosuppression of CX3CR1 tissue-resident macrophages. Our study reveals that the health of the intestinal mucosa is maintained by an axis driven by Treg cells communication with resident macrophages that withhold inflammatory stimuli required for ILC3 function.

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Section: Discussionmentioning

confidence: 99%

LAG3+ Regulatory T Cells Restrain Interleukin-23-Producing CX3CR1+ Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis

et al. 2018

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“…Sir Francis Drake and John Hawkins (the first English slave trader) described a village in the vicinity of LaSoye in the 1590s where Indigenous people “groweth great store of Tobacco: where most of our English and French men barter knives, hatchets, sawes and such like yron tooles in truck of Tobacco” (Honychurch 1997; Andrews 2017 [1972]: 185). This industry, combined with regular raids by the Kalinago on other islands and on European ships, meant Dominica emerged as a locus of commercial activity.…”

Section: Lasoye In Historic Contextmentioning

confidence: 99%

Where strangers met: evidence for early commerce at LaSoye Point, Dominica

Hauser¹,

Armstrong

Wallman

et al. 2019

Antiquity

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“…This negative effect on T cell function is exerted through a poorly understood but unique amino acid sequence (KIEELE) in the intracellular domain (Workman et al, 2002). Importantly, LAG-3 and PD-1 are co-expressed at high levels in tumor-infiltrating lymphocytes (TILs) from murine ovarian tumor and EG7-bearing mice, and blockade of both molecules enhances CD8 + effector T cell frequency and function, thus enhancing anti-tumor immunity (Andrews et al, 2017;Huang et al, 2015;Woo et al, 2012).…”

Section: Introductionmentioning

confidence: 99%