Abstract:SUMMARYExtracts of rabies-infected suckling mouse brains purified by precipitation at pH 4"5, freed from smaller antigens by sedimentation at 161, I8og and digested with RNase, DNase and trypsin show in the ultracentrifuge a component of $20 ~ I6 to I8 which is lacking in extracts of normal suckling mouse brains similarly treated. The largest rabies soluble antigen ('outer antigen': Mead, I962b) has a sedimentation constant S~0 ~ I6 estimated by the 'biological' method of Poison & van Regenmortel 0960. The pur… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.