The Lantern: An ultra-light micro-drive for multi-tetrode recordings in mice and other small animals

Battaglia, Francesco P.; Kalenscher, Tobias; Cabral, Henrique; Winkel, Jasper; Bos, Jeroen J.; Manuputy, Ron; Lieshout, Theo van; Pinkse, Frans; Beukers, Harry; Pennartz, Cyriel M. A.

doi:10.1016/j.jneumeth.2008.12.024

Cited by 50 publications

(48 citation statements)

References 27 publications

(47 reference statements)

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“…The 330 mg system described here weighs ∼1.5% of an adult mouse, representing a substantial improvement over other systems with comparable numbers of recording sites, when considering the combined weight of the electrode and amplifier assemblies [26], [27]. We implanted a system containing a 64 site array into the mouse hippocampus (Figure 8A).…”

Section: Resultsmentioning

confidence: 99%

Multiplexed, High Density Electrophysiology with Nanofabricated Neural Probes

et al. 2011

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Extracellular electrode arrays can reveal the neuronal network correlates of behavior with single-cell, single-spike, and sub-millisecond resolution. However, implantable electrodes are inherently invasive, and efforts to scale up the number and density of recording sites must compromise on device size in order to connect the electrodes. Here, we report on silicon-based neural probes employing nanofabricated, high-density electrical leads. Furthermore, we address the challenge of reading out multichannel data with an application-specific integrated circuit (ASIC) performing signal amplification, band-pass filtering, and multiplexing functions. We demonstrate high spatial resolution extracellular measurements with a fully integrated, low noise 64-channel system weighing just 330 mg. The on-chip multiplexers make possible recordings with substantially fewer external wires than the number of input channels. By combining nanofabricated probes with ASICs we have implemented a system for performing large-scale, high-density electrophysiology in small, freely behaving animals that is both minimally invasive and highly scalable.

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Section: Resultsmentioning

confidence: 99%

Multiplexed, High Density Electrophysiology with Nanofabricated Neural Probes

et al. 2011

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“…Chronically implanted multi-electrode arrays have been increasingly used in neurophysiology experiments with behaving animals (Nicolelis et al, 1997; deCharms et al, 1999; Fee and Leonardo, 2001; Hoffman and McNaughton, 2002; Ainsworth and O'Keefe, 2002; Sinha and Moss, 2007; Eliades and Wang, 2008b; Battaglia et al 2009). The Warp-16 drive (Neuralynx, Inc., 105 Commercial Dr, Bozeman, MT, USA) shown in Figs.…”

Section: Methodsmentioning

confidence: 99%

“…To derive realistic models of the cortical neuronal networks, it is crucial to simultaneously record and study multiple neurons in a cortical region of interest during behavior (Nicolelis and Ribero 2002, Buzsaki 2004). Previous studies have used multi-electrode arrays with sharp metal wires, tetrodes, multi contact silicon probes and microelectromechanical systems (MEMS) electrodes to record neural activity in population of neurons from various animal species (e.g., Nicolelis et al, 1997; deCharms et al, 1999; Fee and Leonardo, 2001; Hoffman and McNaughton, 2002; Ainsworth and O'Keefe, 2002; Muthuswamy et al, 2005; Suner et al, 2005; Sinha and Moss, 2007; Eliades and Wang, 2008b; Battaglia et al, 2009). However single-unit neural recording over an extended period of time from naturally behaving and freely moving animals has posed a number of technical challenges.…”

Section: Introductionmentioning

confidence: 99%

Wireless multi-channel single unit recording in freely moving and vocalizing primates

Roy

Wang

2012

Journal of Neuroscience Methods

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The ability to record well-isolated action potentials from individual neurons in naturally behaving animals is crucial for understanding neural mechanisms underlying natural behaviors. Traditional neurophysiology techniques, however, require the animal to be restrained which often restricts natural behavior. An example is the common marmoset (Callithrix jacchus), a highly vocal New World primate species, used in our laboratory to study the neural correlates of vocal production and sensory feedback. When restrained by traditional neurophysiological techniques marmoset vocal behavior is severely inhibited. Tethered recording systems, while proven effective in rodents pose limitations in arboreal animals such as the marmoset that typically roam in a three-dimensional environment. To overcome these obstacles, we have developed a wireless neural recording technique that is capable of collecting single-unit data from chronically implanted multi-electrodes in freely moving marmosets. A lightweight, low power and low noise wireless transmitter (headstage) is attached to a multi-electrode array placed in the premotor cortex of the marmoset. The wireless headstage is capable of transmitting 15 channels of neural data with signal-to-noise ratio (SNR) comparable to a tethered system. To minimize radio-frequency (RF) and electro-magnetic interference (EMI), the experiments were conducted within a custom designed RF/EMI and acoustically shielded chamber. The individual electrodes of the multi-electrode array were periodically advanced to densely sample the cortical layers. We recorded single-unit data over a period of several months from the frontal cortex of two marmosets. These recordings demonstrate the feasibility of using our wireless recording method to study single neuron activity in freely roaming primates.

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“…With the help of the base screw, the microelectrode can move in the dorso-ventral, anterio-posterior and medio-lateral directions. Several previously described drives are composed of a relatively large number of separate components to prevent electrode rotation during advancement in the brain tissue, many of which require fairly sophisticated machining (Bland et al 1990;Malpeli et al 1992;Korshunov 1995;Battaglia et al 2009). In the present design, the movement of the driving screw is transferred firstly to the microelectrode holder and then to the microelectrode, in a manner that the microelectrode does not rotate or twist during the advancement and retraction movements.…”

Section: Discussionmentioning

confidence: 99%

“…Investigators have developed techniques to record activity within the brain of behaving animals (Korshunov 1995;Kralik et al 2001;Battaglia et al 2009;Galashan et al 2011). These techniques usually involve electrodes attached to a device, in a manner that allows for their gradual advancement into the brain structure of interest.…”

Section: Introductionmentioning

confidence: 99%

A miniature microdrive for recording auditory evoked potentials from awake anurans

Mohammed

Radwan²,

Walkowiak³

et al. 2014

gpb

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Abstract. Electrical activity recording from the brains of awake animals is a corner stone in the study of the neurophysiological basis of behavior. To meet this need, a microelectrode driver suitable for the animal of interest has to be developed. In the present study a miniature microdrive was developed specifically for the leopard toad, Bufo regularis, however, it can be used for other small animals. The microdrive was designed to meet the following requirements: small size, light weight, simple and easy way of attaching and removing, advancing and withdrawing of microelectrode in the animal brain without rotation, can be reused and made from inexpensive materials. To assess the performance of the developed microdrive, we recorded auditory evoked potentials from different auditory centers in the toad's brain. The potentials were obtained from mesencephalic, diencephalic and telencephalic auditory sensitive areas in response to simple and complex acoustic stimuli. The synthetic acoustical tones introduced to the toad were carrying the dominant frequencies of their mating calls.

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The Lantern: An ultra-light micro-drive for multi-tetrode recordings in mice and other small animals

Cited by 50 publications

References 27 publications

Multiplexed, High Density Electrophysiology with Nanofabricated Neural Probes

Multiplexed, High Density Electrophysiology with Nanofabricated Neural Probes

Wireless multi-channel single unit recording in freely moving and vocalizing primates

A miniature microdrive for recording auditory evoked potentials from awake anurans

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The Lantern: An ultra-light micro-drive for multi-tetrode recordings in mice and other small animals

Cited by 50 publications

References 27 publications

Multiplexed, High Density Electrophysiology with Nanofabricated Neural Probes

Multiplexed, High Density Electrophysiology with Nanofabricated Neural Probes

Wireless multi-channel single unit recording in freely moving and vocalizing primates

A miniature microdrive for recording auditory evoked potentials from awake anurans

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Product

Resources

About

A miniature microdrive for recording auditory evoked potentials from awake anurans