The language production system and senile dementia of Alzheimer's type: Neuropathological implications

Patel, P.G.; Satz, Paul

doi:10.1080/02687039408248638

Cited by 13 publications

(9 citation statements)

References 78 publications

(56 reference statements)

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“…The individuals in our study produced phonological paraphasias, false-start errors, and perseverations, and a number also showed the effortful, hesitant speech characteristic of the nonfluent aphasias. This is contrary to claims that phonological processing and phonetic articulation are preserved until the late stages of the disease (Cohn et al, 1991;Patel & Satz, 1994). Given that articulatory and/or phonological disruption appear to be relatively rare in DAT, it is possible that some studies reporting intact speech production have happened not to enroll patients with these disruptions.…”

Section: Discussioncontrasting

confidence: 68%

Phonological and Articulatory Impairment in Alzheimer's Disease: A Case Series

et al. 2000

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Section: Discussioncontrasting

confidence: 68%

Phonological and Articulatory Impairment in Alzheimer's Disease: A Case Series

et al. 2000

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“…This finding argues against the presumed preservation of morpho-syntactic features of language in AD (Forbes et al, 2002;Glosser & Deser, 1991;Patel & Satz, 1994) and is in keeping with a degree of multi-modal language impairment in this group of patients. Altmann and colleagues have previously reported a similar finding in a cohort of probable AD patients (Altmann, Kempler, & Andersen, 2001).…”

Section: Clinical Comparison Of Connected Speechmentioning

confidence: 39%

Abnormalities of connected speech in semantic dementia vs Alzheimer's disease

et al. 2012

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Background: Neurodegenerative syndromes are associated with varying degrees of language impairment. Connected speech analysis provides the most realistic measure of language function but its use has been restricted by operational constraints. Aims: In this prospective study we assessed the relative utility of a picture description task and a semi-structured interview in exposing the language decline in semantic dementia (SD) and typical mild Alzheimer's disease (AD), compared to each other and to healthy volunteers. Methods & Procedures:Our cohort comprised 16 patients with a clinical diagnosis of SD, 20 with mild typical AD, and 30 healthy participants. All speech samples were recorded during a face-to-face interview and were subjected to a well-controlled quantitative analysis.Outcomes & Results: Our results suggest that (a) the picture description task is more sensitive to abnormalities in the semantic measures, whereas the interviews are better at exposing morpho-syntactic deficits; (b) circumlocution is not, as has sometimes been claimed, a salient feature of speech in SD; (c) increases in the frequency of hesitation markers and of phonological and syntactic errors are prominent features of language decline in mild AD; and (d) a 150-word interview sample is adequate to provide a realistic reflection of language impairment. Conclusions: This study compared, for the first time, the two most commonly used methods of eliciting connected speech and documented many similarities in results from the two but also some salient differences in their sensitivity to specific aspects of language deficit. In addition, although replicating some aspects such as anomia, of what is already known about the language impairments in these two conditions, the study provides novel findings for both that could help clinicians in syndromic classification of anomic speech.

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“…Bayles and Kaszniak [46] concluded that phonologic knowledge can be applied by Alzheimer patients who are incapable of meaningful communication. And in a study of phonologic function in mild late-onset DAT patients, Patel and Satz [54] concluded that there were no deficits in sound combination, stress, and general rhythm of sounds. Further, Patel and Satz [54] concluded that phonologic preservation in early-onset DAT applied also to spelling; early-onset patients were able to sound out and spell words they could no longer assign meaning to.…”

Section: Phonologic Impairment In Datmentioning

confidence: 99%