The landscape of long noncoding RNA expression in the goat brain

Varela-Martínez, Endika; Luigi-Sierra, María Gracia; Guan, Dailu; López-Béjar, Manel; Casas, Encarna; Olvera-Maneu, Sergi; Gardela, Jaume; Palomo, Maria Jesús; Osuagwuh, Uchebuchi Ike; Ohaneje, Uchechi Linda; Mármol-Sánchez, Emilio; Amills, Marcel

doi:10.3168/jds.2023-23966

Cited by 2 publications

(1 citation statement)

References 79 publications

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“…A total of 10,254 lncRNAs were identified according to rigorous screening criteria, including 1,676 known lncRNAs and 8,954 novel identified lncRNAs. Characterization of lncRNAs revealed that the majority of them consisted of 2–3 exons (84%), and approximately 54% were under 1 kb in length, consistent with previously reported profiles of lncRNAs in goats ( 32 ). A total of 236 DELs were identified by differential analysis of lncRNAs.…”

Section: Discussionsupporting

confidence: 89%

Transcriptome analysis revealed the characteristics and functions of long non-coding RNAs in the hypothalamus during sexual maturation in goats

Li,

Chao,

Wang

et al. 2024

Front. Vet. Sci.

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The hypothalamus is an essential neuroendocrine area in animals that regulates sexual development. Long non-coding RNAs (lncRNAs) are hypothesized to regulate physiological processes related to animal reproduction. However, the regulatory mechanism by which lncRNAs participate in sexual maturity in goats is poorly known, particularly from birth to sexual maturation. In this study, RNAseq analysis was conducted on the hypothalamus of four developmental stages (1day (D1, n = 5), 2 months (M2, n = 5), 4 months (M4, n = 5), and 6 months (M6, n = 5)) of Jining grey goats. The results showed that a total of 237 differentially expressed lncRNAs (DELs) were identified in the hypothalamus. Among these, 221 DELs exhibited cis-regulatory effects on 693 target genes, while 24 DELs demonstrated trans-regulatory effects on 63 target genes. The target genes of these DELs are mainly involved in biological processes related to energy metabolism, signal transduction and hormone secretion, such as sphingolipid signaling pathway, adipocytokine signaling pathway, neurotrophic signaling pathway, glutamatergic synapse, P53 signaling pathway and GnRH signaling pathway. In addition, XR_001918477.1, TCONS_00077463, XR_001918760.1, and TCONS_00029048 and their potential target genes may play a crucial role in the process of goat sexual maturation. This study advances our understanding of lncRNA in hypothalamic tissue during sexual maturation in goats and will give a theoretical foundation for improving goat reproductive features.

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Section: Discussionsupporting

confidence: 89%

Transcriptome analysis revealed the characteristics and functions of long non-coding RNAs in the hypothalamus during sexual maturation in goats

Li,

Chao,

Wang

et al. 2024

Front. Vet. Sci.

View full text Add to dashboard Cite

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Long non-coding RNA (LncRNA) and epigenetic factors: their role in regulating the adipocytes in bovine

Jilo,

Abebe,

Wang

et al. 2024

Front. Genet.

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Investigating the involvement of long non-coding RNAs (lncRNAs) and epigenetic processes in bovine adipocytes can provide valuable new insights into controlling adipogenesis in livestock. Long non-coding RNAs have been associated with forming chromatin loops that facilitate enhancer-promoter interactions during adipogenesis, as well as regulating important adipogenic transcription factors like C/EBPα and PPARγ. They significantly influence gene expression regulation at the post-transcriptional level and are extensively researched for their diverse roles in cellular functions. Epigenetic modifications such as chromatin reorganization, histone alterations, and DNA methylation subsequently affect the activation of genes related to adipogenesis and the progression of adipocyte differentiation. By investigating how fat deposition is epigenetically regulated in beef cattle, scientists aim to unravel molecular mechanisms, identify key regulatory genes and pathways, and develop targeted strategies for modifying fat deposition to enhance desirable traits such as marbling and meat tenderness. This review paper delves into lncRNAs and epigenetic factors and their role in regulating bovine adipocytes while focusing on their potential as targets for genetic improvement to increase production efficiency. Recent genomics advancements, including molecular markers and genetic variations, can boost animal productivity, meeting global demands for high-quality meat products. This review establishes a foundation for future research on understanding regulatory networks linked to lncRNAs and epigenetic changes, contributing to both scholarly knowledge advancement and practical applications within animal agriculture.

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The landscape of long noncoding RNA expression in the goat brain

Cited by 2 publications

References 79 publications

Transcriptome analysis revealed the characteristics and functions of long non-coding RNAs in the hypothalamus during sexual maturation in goats

Transcriptome analysis revealed the characteristics and functions of long non-coding RNAs in the hypothalamus during sexual maturation in goats

Long non-coding RNA (LncRNA) and epigenetic factors: their role in regulating the adipocytes in bovine

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