The landscape of circular RNAs and mRNAs in bovine milk exosomes

Wang, Yanhong; Li, Dewei; Wang, Yanhuan; Li, Menglu; Fang, Xingtang; Chen, Hong; Zhang, Chunlei

doi:10.1016/j.jfca.2018.12.004

Cited by 20 publications

(14 citation statements)

References 58 publications

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“…Conservation of many circRNAs between human, cow, and mouse was reported. This conservation may confirm the possible role of circRNAs in biological functions (Wang, Li, et al, 2019). Due to the importance of the biomarker role of circRNAs in noninvasive detection and personalized medicine and also their critical roles in cancer biogenesis and development, more supplementary studies are needed to discover molecular mechanisms of their biological functions.…”

Section: Discussionmentioning

confidence: 60%

Circular RNA; a new biomarker for breast cancer: A systematic review

Jahani

Nazeri

Majidzadeh‐A

et al. 2020

Journal Cellular Physiology

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Circular RNAs (circRNAs) were recently discovered as a looped subset of competing endogenous RNAs, with an ability to regulate gene expression by microRNA sponging. There are several studies on their potential roles in cancer development, such as colorectal cancer and basal cell carcinoma. However, there is still a significant gap in the knowledge about circRNA functions in breast cancer (BC) progression. The current study systematically reviewed circRNA biogenesis and their potential roles as a novel biomarker in BC on published studies of the MEDLINE®/PubMed, Cochrane®, and Scopus® databases. The obtained results showed a general dysregulation of circRNAs expression in BC cells with a cell‐type and stage‐specific manner. The potential connection between circRNAs and BC cell proliferation, apoptosis, metastasis, and chemotherapy sensitivity and resistance were discussed.

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Section: Discussionmentioning

confidence: 60%

Circular RNA; a new biomarker for breast cancer: A systematic review

Jahani

Nazeri

Majidzadeh‐A

et al. 2020

Journal Cellular Physiology

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“…Circular RNAs (circRNAs) are a recently identified genetic element that are abundantly expressed, highly conserved between different animal species (Hanan et al, 2017), and are involved in the foundation of mammary gland growth and development (Zhang et al, 2015;Zhu et al, 2016), milk synthesis (Zhang C. et al, 2016), and secretion and transportation (Wang et al, 2019). HS greatly impacts circRNA biogenesis, and heat-induced circRNAs perform substantial regulatory functions through circRNA-mediated competing endogenous RNA (ceRNA) networks (Pan et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Emerging Roles of Heat-Induced circRNAs Related to Lactogenesis in Lactating Sows

Sun

Zhang

et al. 2020

Front. Genet.

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Heat stress negatively influences milk production and disrupts normal physiological activity of lactating sows, but the precious mechanisms by which hyperthermia adversely affects milk synthesis in sows still remain for further study. Circular RNAs are a novel class of non-coding RNAs with regulatory functions in various physiological and pathological processes. The expression profiles and functions of circRNAs of sows in lactogenesis remain largely unknown. In the present study, long-term heat stress (HS) resulted in a greater concentration of serum HSP70, LDH, and IgG, as well as decreased levels of COR, SOD, and PRL. HS reduced the total solids, fat, and lactose of sow milk, and HS significantly depressed CSNas1, CSNas2, and CSNk biosynthesis. Transcriptome sequencing of lactating porcine mammary glands identified 42 upregulated and 25 downregulated transcripts in HS vs. control. Functional annotation of these differentially-expressed transcripts revealed four heat-induced genes involved in lactation. Moreover, 29 upregulated and 21 downregulated circRNA candidates were found in response to HS. Forty-two positively correlated circRNA-mRNA expression patterns were constructed between the four lactogenic genes and differentially expressed circRNAs. Five circRNA-miRNA-mRNA post-transcriptional networks were identified involving genes in the HS response of lactating sows. In this study we establish a valuable resource for circRNA biology in sow lactation. Analysis of a circRNA-miRNA-mRNA network further uncovered a novel layer of post-transcriptional regulation that could be used to improve sow milk production.

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“…circRNAs appear to be highly conserved across mammals, and exosomal circRNAs are detected in bovine milk by high-throughput RNA sequencing analysis. The conserved nature might confirm the role of circRNAs in biological functions (Wang Y. H. et al, 2018 ). Exosomal circRNAs can regulate signaling pathways and participate in cell proliferation, tumor metastasis, and drug resistance progression in cancer (Wang et al, 2019 ).…”

Section: Discussionmentioning

confidence: 88%

Circular RNA as a Potential Biomarker for Melanoma: A Systematic Review

Tang

Zhang

et al. 2021

Front. Cell Dev. Biol.

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Circular RNAs (circRNAs) are newly discovered RNAs with covalently looped structures. Due to their resistance to RNAase degradation and tissue-specific expression, circRNAs are expected to be potential biomarkers in early diagnosis and target treatment of many diseases. However, the role of circRNAs in melanoma still needs to be systematically reviewed for better understanding and further research. Based on published articles in PubMed, Embase, Cochrane Library, and Web of Science database, we systematically reviewed the implications and recent advances of circRNAs in melanoma, focusing on function, mechanism, and correlation with melanoma progression. According to inclusion and exclusion criteria, a total of 19 articles were finally included in this systematic review. Of the 19 studies, 17 used human samples, including melanoma tissues (n = 16) and blood serum of patients with melanoma (n = 1). The sample size of the study group ranged from 20 to 105 based on the reported data. Several studies explored the association between circRNAs and clinicopathological characteristics. circRNA dysregulation was commonly observed in melanoma patients. circRNAs function in melanoma by miRNA sponging and interaction with RNA binding proteins (RBP), ultimately controlling several important signaling pathways and cancer-related cellular processes, including proliferation, migration, invasion, metastasis, apoptosis, and glucose metabolism. circRNA expression could be associated with prognostic factors and drug responses, consolidating the potential clinical value in melanoma. Herein, we clarified the functional, prognostic, and predictive roles of circRNAs in melanoma in this systematic review, providing future directions for studies on melanoma-associated circRNAs.

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The landscape of circular RNAs and mRNAs in bovine milk exosomes

Cited by 20 publications

References 58 publications

Circular RNA; a new biomarker for breast cancer: A systematic review

Circular RNA; a new biomarker for breast cancer: A systematic review

Emerging Roles of Heat-Induced circRNAs Related to Lactogenesis in Lactating Sows

Circular RNA as a Potential Biomarker for Melanoma: A Systematic Review

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