The lactam‐amino acid equilibria for ethylpyrrolidone and polyvinylpyrrolidone

Frank, H. P.

doi:10.1002/pol.1954.120120149

Cited by 27 publications

(16 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PSf is highly hydrophobic and does not swell appreciably. When PSf is used to fabricate medical devices such as dialysis membranes, either the whole device or only its surface needs to be covered with a hydrophilizing agent such as PVP, which is an amphiphilic and chemically inert polymer having a lactam with an internal amide bond [4].…”

Section: Introductionmentioning

confidence: 99%

Poly(N-vinyl-2-pyrrolidone) elution from polysulfone dialysis membranes by varying solvent and wall shear stress

et al. 2012

View full text Add to dashboard Cite

Some dialysis patients are treated with post-hemodiafiltration (HDF); the blood viscosity of the patients who undergo post-HDF is higher than that of the patients who undergo conventional hemodialysis. This study aims to evaluate poly(N-vinyl-2-pyrrolidone) (PVP) elution from PSf dialysis membranes by varying solvents and high wall shear stress caused by blood viscosity. We tested three commercial membranes: APS-15SA (Asahi Kasei Kuraray), CX-1.6U (Toray) and FX140 (Fresenius). Dialysate and blood sides of the dialyzers were primed with reverse osmosis (RO) water and saline. RO water, saline and dextran solution (2.9 and 5.8 mPa s) were circulated in the blood side. The amount of eluted PVP was determined by 0.02 N iodometry. The hardness and adsorption force of human serum albumin (HSA) on the membrane surfaces were measured by the atomic force microscope. When wall shear stress was increased using dextran, the amount of PVP eluted by the 2.9 mPa s solution equaled that eluted by the 5.8 mPa s solution with APS-15SA and CX-1.6U sterilized by gamma rays. The amount of PVP eluted by the 5.8 mPa s solution was higher than that eluted by the 2.9 mPa s solution with FX140 sterilized by autoclaving. The wall shear stress increased the PVP elution from the surface, hardness and adsorption force of HSA. Sufficient gamma-ray irradiation is effective in decreasing PVP elution.

show abstract

Section: Introductionmentioning

confidence: 99%

Poly(N-vinyl-2-pyrrolidone) elution from polysulfone dialysis membranes by varying solvent and wall shear stress

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Dependence of G h , on pH (5% G-2, persulfate/PVP = 0.5, SOOC). Lower line is the equilibrium conversion of PVP to polymeric amino acid at 100°C 21. …”

mentioning

confidence: 99%

Crosslinking aqueous poly(vinyl pyrrolidone) solutions by persulfate

Anderson

Rodriguez

Thurston

1979

J. Appl. Polym. Sci.

View full text Add to dashboard Cite

SynopsisAqueous solutions with 1.5 to 6.5 wt-% poly(viny1 pyrrolidone), PVP, are converted to stable gels by reaction with potassium persulfate. Large quantities of persulfate are needed for high-modulus gels, 50% to 150% of the weight of PVP being required typically. The shear modulus G' can be measured during reaction by making the gel the restoring element in a simple torsion pendulum. The increase in modulus to a maximum plateau value of GLm can be expressed as a first-order process:where t is elapsed time of reaction and K increases with the square root of polymer concentration. G-varies with the second power of the polymer concentration. It also increases rapidly with increasing temperature of reaction and with persulfateIPVP ratio.

show abstract

“…Because of remarkable amphiphilic properties, good solubility in water and many conventional organic solvents resulting in high biocompatibility, adhesive and binding power, this non-toxic compound belonging to polymeric lactam with an internal amide group [1] is applied as amorphous binder for many drug substrates to form the tablets of promising pharmaceutical functionality [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…Polyvinylpyrrolidone (PVP), (C6H9ON)n, has been widely used in pharmaceuticals industry as high-efficient nonionic stabilizer, dispersant and delivery agent in production of many drugs [1][2][3].…”

Section: Introductionmentioning

confidence: 99%