The Lack of Utility of the Latex Agglutination Test for Detection of Candida Antigen in the Diagnosis of Systemic Candidiasis

Df, Battafarano; Jefferies, B; Ck, McAllister; Jw, Kelly

doi:10.1093/milmed/156.6.283

Cited by 3 publications

(2 citation statements)

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“…The development of an- (7,118). However, the specificity and sensitivity of the Cand-Tec assay vary among reports (7,8,47,156). Furthermore, false-positive results due to rheumatoid factor have been observed (28).…”

Section: Invasive Candidiasismentioning

confidence: 99%

Current Status of Nonculture Methods for Diagnosis of Invasive Fungal Infections

2002

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The incidence of invasive fungal infections has increased dramatically in recent decades, especially among immunocompromised patients. However, the diagnosis of these infections in a timely fashion is often very difficult. Conventional microbiologic and histopathologic approaches generally are neither sensitive nor specific, and they often do not detect invasive fungal infection until late in the course of disease. Since early diagnosis may guide appropriate treatment and prevent mortality, there has been considerable interest in developing nonculture approaches to diagnosing fungal infections. These approaches include detection of specific host immune responses to fungal antigens, detection of specific macromolecular antigens using immunologic reagents, amplification and detection of specific fungal nucleic acid sequences, and detection and quantitation of specific fungal metabolite products. This work reviews the current status and recent developments as well as problems in the design of nonculture diagnostic methods for invasive fungal infections

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Section: Invasive Candidiasismentioning

confidence: 99%

Current Status of Nonculture Methods for Diagnosis of Invasive Fungal Infections

2002

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“…There have been several studies on the detection of serum Candida antigen in the diagnosis of invasive candidiasis in adults; the results, however, are controversial (9)(10)(11)(12)(13)(14)(15)(16)(17). Serum Candida antibodies, in contrast, have been studied less extensively.…”

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confidence: 99%

Prospective evaluation of Candida antigen and antibody assays for detection of Candida infections in children with malignant disease

Örmälä

Korppi

et al. 1995

Acta Paediatrica

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The clinical efficacy of assays for Candida albicans antigens by latex agglutination and for antibodies by indirect haemagglutination were prospectively evaluated in the diagnosis of invasive Candida infections in 38 children suffering from acute leukaemia or other malignant disease. The controls were 74 other patients without any malignancy; 72 of these had no signs or symptoms of fungal infections, but 2 had an invasive C. albicans infection. During a period of 21 months, 302 serum samples were tested by both assays, and the results were compared with clinical and other microbiological data. Invasive fungal infection was diagnosed on clinical grounds in 2 of the immunocompromised children, and periodic gut colonization was demonstrated in 11 of 36 (31%) children in this group. Positive Candida antigen was detected in 14 patients (37%) and a positive antibody titre in 7 patients (18%). Colonization was not correlated with antigen or antibody titre. Compared with the presence of invasive fungal infection, the antibody assay detected all four infections, whereas the antigen assay detected one of the two C. albicans septicaemias. Although the Candida antibody assay performed well, a detectable change in antibody titres appeared only slowly. Thus it was of no clinical help when antifungal treatment was to be considered. Follow-up of antibody titres, however, gave confirmation of the presence of fungal infection as well as the response to antifungal treatment.

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Rapid simultaneous detection and identification of six species Candida using polymerase chain reaction and reverse line hybridization assay

Xiang

Xiong²,

Liu³

et al. 2007

Journal of Microbiological Methods

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The Lack of Utility of the Latex Agglutination Test for Detection of Candida Antigen in the Diagnosis of Systemic Candidiasis

Cited by 3 publications

References 0 publications

Current Status of Nonculture Methods for Diagnosis of Invasive Fungal Infections

Current Status of Nonculture Methods for Diagnosis of Invasive Fungal Infections

Prospective evaluation of Candida antigen and antibody assays for detection of Candida infections in children with malignant disease

Rapid simultaneous detection and identification of six species Candida using polymerase chain reaction and reverse line hybridization assay

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