Abstract:Myocardial infarction (MI) is a dynamic process that leads to ventricular remodeling (VR) and heart failure (HF). Previous studies established that Galectin‐3 (Gal‐3), is increased during infarction and it is a prognostic marker of HF. Here, we aimed to study the effects of genetic mutation of Gal3 on macrophages infiltration, fibrosis and MMP‐2 as well as VR after MI in mice. Adult male C57 and Gal3KO mice were subjected to permanent coronary artery ligature and sham. After 1 week (w) post‐MI, echocardiograph… Show more
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