The lack of age as a significant prognostic factor in nonmetastatic breast cancer

Ezzat, A.; Raja, M. A.; Zwaan, F.; Brigden, Malcolm L.; Rostom, A.Y.; Bazarbashi, Shouki

doi:10.1016/s0748-7983(98)80120-0

Cited by 21 publications

(6 citation statements)

References 13 publications

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“…However, some authors have demonstrated otherwise, that young age is not an adverse prognosticating factor 30−34 . One of the larger studies supporting this was reported by Schmidt et al.…”

Section: Discussionmentioning

confidence: 89%

Breast cancer in young Asian women: Study on survival

Foo

Chong

et al. 2005

ANZ Journal of Surgery

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Section: Discussionmentioning

confidence: 89%

Breast cancer in young Asian women: Study on survival

Foo

Chong

et al. 2005

ANZ Journal of Surgery

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“…[2][3][4] However, at the time of diagnosis, older adult patients more often have an advanced-stage breast cancer and larger tumors. 1 There has been conflicting data on lymph node involvement and aging; some studies showed decreased involvement in older adult patients, [5][6][7] whereas others did not find an effect 3,4,8 or showed increased involvement with increasing age. 1,9 Because of discordant results between previous studies, we decided to perform a retrospective analysis as-sessing the connection between age and lymph node involvement, while adjusting for other clinicopathologic variables.…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Age and Axillary Lymph Node Involvement in Women With Breast Cancer

Wildiers

Calster

Poll‐Franse

et al. 2009

JCO

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Axillary LN involvement varies with age at diagnosis; its probability decreases with increasing age up to the age of approximately 70 years, but increases again thereafter. However, this increase is mainly seen in smaller tumors and suggests a different behavior of small breast cancers in older adult patients. We hypothesize that decreased immune defense mechanisms, related with aging, may play a role in earlier invasion into LNs.

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“…H. S. Shukla features, and outcome of treatment has been widely reported [1][2][3]. It has been established that BC in many Asian and African countries, affect younger females, who present themselves in advanced stage with poor prognostic features and has worse outcome when compared to their counterparts in the Western countries [4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Significance of Her-2/neu protein over expression in Indian breast cancer patients

et al. 2007

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Background Racial disparity in presentation and outcome of breast cancer is established but cause is unexplained . Many studies show various molecular markers for racial differences in the prognosis of breast cancer. There is scarcity of data on prognostic signifi cance of HER-2/neu in Indian breast cancer. Aims and ObjectiveTo know incidence and prognostic signifi cance of HER-2/neu expression in Indian patients.To correlate HER-2/neu Expression with other prognostic markers and ER/PR Receptor status. Statistical Analysis Data was analyzed by univariate and multivariate analysis for all prognostic factors. Signifi cance was calculated by using Chi square test and survival analysis by using Kaplan Meier survival curve. Material and MethodsResults The median age of 112 patients was 46.56 (±9.55) years. HER-2/neu over expression was present in 46.37%. Signifi cant correlation was found between HER-2/neu over expression and lymph node status, grade of tumor and ER/ PR receptor status. Median follow up period of 23 months. There was signifi cant tumour free survival advantage (p < 0.01) and overall survival advantage (p < 0.001) in patients with HER-2/neu negative expression.Conclusion HER-2/neu oncogene over expression is higher (46.37%) among Indian patients in comparison to 25-30% shown in most western literature. HER-2/neu oncogene over expression signifi cantly correlates with grade, lymph node involvement, ER/PR status and also affects survival.

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The lack of age as a significant prognostic factor in nonmetastatic breast cancer

Cited by 21 publications

References 13 publications

Breast cancer in young Asian women: Study on survival

Breast cancer in young Asian women: Study on survival

Relationship Between Age and Axillary Lymph Node Involvement in Women With Breast Cancer

Significance of Her-2/neu protein over expression in Indian breast cancer patients

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