The lack of acute effect of low-to-moderate-dose ionising radiation on endothelial proteome

Radiation-induced Changes in the Electrophoretic Profile of Serum Albumin

“…Recently, proteomic analysis from radiation exposure subjects has been addressed 12 . Tapio et al, 2013, described a series of changes for different blood proteins, as SILAC, which is very sensitive to radiation, due to inhibition of its synthesis 13 .By contrast, Nylund et al, 2013, reported no changes in the protein expressions of the endothelial cell line (EA.hy926) submitted to radiation 13,14 .Yan et al, 2010, described the metabolism increase of skin fibroblasts and concluded that such behavior is due to resistance mechanisms of radiation cells 15 .Further studies, Yuasa et al, 2006, showed that the changes in protein expressions shall start with the interactions of radiation in the process of DNA replication, which can be occasional or permanent, and this gene reprogramming transmitted to new populations or new cell generations 16 . In additional studies, involving electromagnetic radiation such as cell phone signal or computer, Karinem et al, 2008, based on a female volunteer group, showed small changes in skin protein expressions although not conclusive 17 .…”

“…Falcão et al also found TGF and MMP9 metalloproteinase alterations in skin induced by UV radiation, which may be related to cancer induction 20 .Thus, protein transcription and proteomic irradiation effects causing physiological changes and the pathological establishment had already been observed. All proteomicreviewedstudies [10][11][12][13][14][15][16][17][18][19][20] were specific and targeted a physiological condition, and their findings cannot be generalized. However, those demonstrated the possibility of protein modulation induced by radiation in diverse human tissues.…”