The L. E. phenomenon and systemic lupus erythematosus

Louis, J; Limarzi, Louis R.

doi:10.1016/0021-9681(58)90052-3

Cited by 9 publications

(3 citation statements)

References 23 publications

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“…Clinically, many cases have indeed a fairly uniform course, and few distinctive features have been recognized, other than the widely accepted predominance of the lymphocytic type in childhood. The introduction of new forms of treatment has, however, shown a need for a re-assessment of this question, since there are reports from several authors that the various types may respond differentially to a chemotherapeutic approach (Haut, Altman, Wintrobe, and Cartwright, 1959;Freireich, Gehan, Sulman, Boggs, and Frei, 1961;Boggs et al, 1962), while others have found factors such as the patient's age of greater importance (Ellison, 1956;Louis, Sanford, and Limarzi, 1958 Of all the haematological criteria used in the attempted classification by far the most useful was the presence of signs pointing to a transition of the blasts to more mature members of one or the other cell series. Thus many cases classed as granulocytic showed some degree of cytoplasmic granulation in at least a proportion of the primitive cells; others had a predominance of early myelocytes.…”

mentioning

confidence: 99%

Cellular types in acute leukaemia: diagnosis and significance

Gunz¹,

Burry²

1963

J Clin Pathol

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confidence: 99%

Cellular types in acute leukaemia: diagnosis and significance

Gunz¹,

Burry²

1963

J Clin Pathol

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“…The presence of LE cells was included in the list of the classification criteria for SLE [ 14 , 17 ] and related to more severe clinical manifestations [ 22 , 23 ]. The LE cell was rarely observed in other rheumatic [ 24 ] and non-rheumatic disorders [ 25 ], but published data on the diagnostic accuracy of the LE cell test in unselected patients are still missing [ 22 , 26 , 27 ]. Previous studies showed that the phenomenon is dependent on anti-dsDNA antibodies [ 21 ] and anti-histone antibodies, in particular anti-histone H1 antibodies [ 28 ].…”

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confidence: 99%

The assessment of serum-mediated phagocytosis of necrotic material by polymorphonuclear leukocytes to diagnose and predict the clinical features of systemic lupus erythematosus: an observational longitudinal study

et al. 2016

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BackgroundSerum-mediated phagocytosis of antibody- and complement-opsonized necrotic cell material (NCM) by polymorphonuclear leukocytes can be quantified by using a flow cytometry–based assay. The phagocytosis of necrotic cell material (PNC) assay parallels the well-known lupus erythematosus cell test. In this study, we aimed to investigate the diagnostic accuracy of the assay and the relationship with clinical manifestations and disease activity in systemic lupus erythematosus (SLE).MethodsThe diagnostic accuracy for SLE diagnosis of the PNC assay was studied by cross-sectional assessment of blood samples from 148 healthy control subjects and a multicenter rheumatic group (MRG) of 529 patients with different rheumatic symptoms. A cohort of 69 patients with an established SLE diagnosis (SLE cohort) underwent longitudinal clinical and laboratory follow-up for analysis of the temporal relationships between PNC positivity and specific clinical manifestations.ResultsIn 35 of 529 MRG patients, 13 of whom had SLE, the PNC assay result was positive. Combined positivity of the PNC assay and anti–double-stranded DNA antibodies increased specificity and positive predictive value for SLE diagnosis to 0.99 and 0.67, respectively. In the longitudinal study, 42 of 69 SLE cohort patients had positive results in the PNC assay at least once. PNC assay positivity was associated with current hematological manifestations and could predict mucocutaneous manifestations. When combined with hypocomplementemia, PNC positivity preceded increased Systemic Lupus Erythematosus Disease Activity Index 2000 score, glomerulonephritis, and alopecia.ConclusionsSerum-mediated PNC by polymorphonuclear leukocytes is commonly but not exclusively seen in patients with SLE. The PNC assay may be used in follow-up of patients with SLE and, especially in combination with other routinely assessed laboratory tests, may help to predict flares and different clinical manifestations, including glomerulonephritis. Our results encourage further development of the PNC assay as a complementary laboratory tool in management of patients with SLE.

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“…cell phenomenon, although Louis and Limarzi (1958) have recently shown that the number of positive tests may be increased by examining blood and marrow in parallel.…”

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confidence: 99%

Marrow biopsy in the diagnosis of pyrexia of undetermined origin

Gower¹

1963

Journal of Clinical Pathology

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The L. E. phenomenon and systemic lupus erythematosus

Cited by 9 publications

References 23 publications

Cellular types in acute leukaemia: diagnosis and significance

Cellular types in acute leukaemia: diagnosis and significance

The assessment of serum-mediated phagocytosis of necrotic material by polymorphonuclear leukocytes to diagnose and predict the clinical features of systemic lupus erythematosus: an observational longitudinal study

Marrow biopsy in the diagnosis of pyrexia of undetermined origin

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