The Krüppel-like factor 4 controls biosynthesis of thyrotropin-releasing hormone during hypothalamus development

Pérez‐Monter, Carlos; Martínez-Armenta, Miriam; Miquelajáuregui, Amaya; Furlan-Magaril, Mayra; Varela‐Echavarría, Alfredo; Recillas‐Targa, Félix; May, Víctor; Charlí, Jean-Louis; Pérez-Martı́nez, Leonor

doi:10.1016/j.mce.2010.12.020

Cited by 17 publications

(19 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2), which likely explains some of the previously reported KLF-mediated steatotic effects [29]. Once identified, we designed specific oligonucleotides encompassing these Krüppel sites (KEM) [22] (Fig. 2 & Supplementary Fig.…”

Section: The Pparg Gene Promoter Recruits Klf6 and Klf9 Under Steatomentioning

confidence: 99%

“…Western-blot was performed as described elsewhere [22] using 30 mg of nuclear extracts and the following antibodies: anti-KLF6…”

Section: Rt-pcr and Western Blottingmentioning

confidence: 99%

“…ChIP was performed as described previously [22]. The chromatin (fragmented to 300e600 bp) was subjected to immunoprecipitation using 5 mg of anti-KLF5 (sc-20691), anti-KLF6 (sc-7158) or anti-KLF9 antibody (sc-12994), anti-POL-II or control IgG.…”

Section: Chromatin Immunoprecipitation (Chip)mentioning

confidence: 99%

“…Confluent HepG2 cells were subjected to transient plasmid transfection as previously described [22]. The pIG-mKLF5 (kindly donated by Dr. J. M. Wells), pCMV-Tag2-KLF6 (A gift from Dr. G.J.…”

Section: Transient Plasmid Transfection Experimentsmentioning

confidence: 99%

See 3 more Smart Citations

The activation of peroxisome proliferator-activated receptor γ is regulated by Krüppel-like transcription factors 6 & 9 under steatotic conditions

Escalona-Nandez

Guerrero-Escalera

Estanes-Hernández

et al. 2015

Biochemical and Biophysical Research Communications

Self Cite

View full text Add to dashboard Cite

Section: The Pparg Gene Promoter Recruits Klf6 and Klf9 Under Steatomentioning

confidence: 99%

“…Western-blot was performed as described elsewhere [22] using 30 mg of nuclear extracts and the following antibodies: anti-KLF6…”

Section: Rt-pcr and Western Blottingmentioning

confidence: 99%

Section: Chromatin Immunoprecipitation (Chip)mentioning

confidence: 99%

Section: Transient Plasmid Transfection Experimentsmentioning

confidence: 99%

See 2 more Smart Citations

The activation of peroxisome proliferator-activated receptor γ is regulated by Krüppel-like transcription factors 6 & 9 under steatotic conditions

Escalona-Nandez

Guerrero-Escalera

Estanes-Hernández

et al. 2015

Biochemical and Biophysical Research Communications

Self Cite

View full text Add to dashboard Cite

“…It has been shown that KLFs can regulate and contribute to a variety of normal neurobiological activities, including neurite outgrowth and axon regeneration (Moore et al, 2009; Caiazzo et al, 2010; Avci et al, 2012; Blackmore et al, 2012), neuronal differentiation and migration (Caiazzo et al, 2010; Ohtsuka et al, 2011; Qin et al, 2011; Qin and Zhang, 2012; Seo et al, 2012), neuronal development and plasticity (Laub et al, 2006; Bonett et al, 2009; Scobie et al, 2009; Caiazzo et al, 2011; Bagamasbad et al, 2012), astroglial activation (Qin et al, 2011), microglial activation (Kaushik et al, 2010; Kaushik et al, 2012), oligodendrocyte differentiation and myelin regeneration (Duncan et al, 2012), neurogenesis (Scobie et al, 2009; Perez-Monter et al, 2011), and cell reprogramming (Kim et al, 2011) (Table 1). Interestingly, more attention has been paid to the physiological functions of KLF 4, 6, 7, and 9 in the nervous system.…”

Section: Role Of Klfs In Nervous System Development and Regenerationmentioning

confidence: 99%

Krüpple-like factors in the central nervous system: novel mediators in Stroke

et al. 2013

View full text Add to dashboard Cite

Transcription factors play an important role in the pathophysiology of many neurological disorders, including stroke. In the past three decades, an increasing number of transcription factors and their related gene signaling networks have been identified, and have become a research focus in the stroke field. Krüppel-like factors (KLFs) are members of the zinc finger family of transcription factors with diverse regulatory functions in cell growth, differentiation, proliferation, migration, apoptosis, metabolism, and inflammation. KLFs are also abundantly expressed in the brain where they serve as critical regulators of neuronal development and regeneration to maintain normal brain function. Dysregulation of KLFs has been linked to various neurological disorders. Recently, there is emerging evidence that suggests KLFs have an important role in the pathogenesis of stroke and provide endogenous vaso- or neuro- protection in the brain’s response to ischemic stimuli. In this review, we summarize the basic knowledge and advancement of these transcriptional mediators in the central nervous system, highlighting the novel roles of KLFs in stroke.

show abstract

Hypothalamus‐Pituitary‐Thyroid Axis

Ortiga-Carvalho

Chiamolera

Pazos‐Moura

et al. 2016

Comprehensive Physiology

293

222

View full text Add to dashboard Cite

The hypothalamus-pituitary-thyroid (HPT) axis determines the set point of thyroid hormone (TH) production. Hypothalamic thyrotropin-releasing hormone (TRH) stimulates the synthesis and secretion of pituitary thyrotropin (thyroid-stimulating hormone, TSH), which acts at the thyroid to stimulate all steps of TH biosynthesis and secretion. The THs thyroxine (T4) and triiodothyronine (T3) control the secretion of TRH and TSH by negative feedback to maintain physiological levels of the main hormones of the HPT axis. Reduction of circulating TH levels due to primary thyroid failure results in increased TRH and TSH production, whereas the opposite occurs when circulating THs are in excess. Other neural, humoral, and local factors modulate the HPT axis and, in specific situations, determine alterations in the physiological function of the axis. The roles of THs are vital to nervous system development, linear growth, energetic metabolism, and thermogenesis. THs also regulate the hepatic metabolism of nutrients, fluid balance and the cardiovascular system. In cells, TH actions are mediated mainly by nuclear TH receptors (210), which modify gene expression. T3 is the preferred ligand of THR, whereas T4, the serum concentration of which is 100-fold higher than that of T3, undergoes extra-thyroidal conversion to T3. This conversion is catalyzed by 5'-deiodinases (D1 and D2), which are TH-activating enzymes. T4 can also be inactivated by conversion to reverse T3, which has very low affinity for THR, by 5-deiodinase (D3). The regulation of deiodinases, particularly D2, and TH transporters at the cell membrane control T3 availability, which is fundamental for TH action. © 2016 American Physiological Society. Compr Physiol 6:1387-1428, 2016.

show abstract

The Krüppel-like factor 4 controls biosynthesis of thyrotropin-releasing hormone during hypothalamus development

Cited by 17 publications

References 35 publications

The activation of peroxisome proliferator-activated receptor γ is regulated by Krüppel-like transcription factors 6 & 9 under steatotic conditions

The activation of peroxisome proliferator-activated receptor γ is regulated by Krüppel-like transcription factors 6 & 9 under steatotic conditions

Krüpple-like factors in the central nervous system: novel mediators in Stroke

Hypothalamus‐Pituitary‐Thyroid Axis

Contact Info

Product

Resources

About