The Korean urban rural elderly cohort study: study design and protocol

Lee, Eun Young; Kim, Hyeon Chang; Rhee, Yumie; Youm, Yoosik; Kim, Kyoung Min; Lee, Ju Mi; Choi, Dong Phil; Yun, Young; Kim, Chang Oh

doi:10.1186/1471-2318-14-33

Cited by 39 publications

(45 citation statements)

References 16 publications

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“…A total of 2942 participants have been recruited to date, and this cohort will be followed for over 10 years. Additional details can be found in the previously outlined study protocol . Briefly, all participants undergo health examinations, including physical examination, face‐to‐face interview and laboratory tests.…”

Section: Methodssupporting

confidence: 92%

“…The Korean version of the activities of daily living and the geriatric depression scale‐short form, were used to assess functional status and depressive symptoms, respectively. Major depression was defined as a score of more than 10 points . Smoking and alcohol consumption were also investigated, and exercise was assessed by frequency and intensity.…”

Section: Methodssupporting

confidence: 92%

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Association of metabolic syndrome and 25‐hydroxyvitamin D with cognitive impairment among elderly Koreans

Lee

Kim

et al. 2016

Geriatrics Gerontology Int

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Section: Methodssupporting

confidence: 92%

Section: Methodssupporting

confidence: 92%

Association of metabolic syndrome and 25‐hydroxyvitamin D with cognitive impairment among elderly Koreans

Lee

Kim

et al. 2016

Geriatrics Gerontology Int

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“…The KURE study is a community-based cohort study involving community-dwelling elderly persons aged 65 years and older [13]. All subjects underwent a full health examination, including blood analysis, BMD analysis, and fracture risk assessment.…”

Section: Methodsmentioning

confidence: 99%

“…Accordingly, we hypothesized that normal TSH levels in the lower range could negatively affect not only the BMD, but also femoral geometry parameters, thereby leading to an increased risk of hip fractures. In this report, in order to estimate bone geometry parameters of the proximal femur based on TSH levels, we analyzed data from the Korean Urban Rural Elderly (KURE) study [13], a cohort study of the Korean elderly population.…”

mentioning

confidence: 99%

Low Normal TSH levels are Associated with Impaired BMD and Hip Geometry in the Elderly

Lee¹,

Kim²,

Lee³

et al. 2016

Aging and disease

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Subclinical hyperthyroidism is known to be associated with the risk of fractures in elderly people. However, there are few studies assessing whether low normal thyroid-stimulating hormone (TSH) levels affect bone density and geometry. Here, we aimed to assess the influence of the TSH level on bone mineral density (BMD) and geometry in elderly euthyroid subjects. This was a cross-sectional cohort study. A total of 343 men and 674 women with euthyroidism were included and analyzed separately. The subjects were divided into tertiles based on the serum TSH level. The BMD and geometry were measured using dual-energy X-ray absorptiometry and a hip structural analysis program. Multiple regression analysis was used to compute the odds ratios of osteoporosis in the lower TSH tertile group and the association between geometry parameters and the TSH level. We found that the femoral neck and total hip BMDs were lower in the lower TSH tertile group. In women, the cross-sectional area and cortical thickness of the femur were negatively associated with the TSH level in all three regions (the narrow neck, intertrochanter, and femoral shaft); however, in men, these geometry parameters were significantly associated with the TSH level only in the intertrochanter region. The buckling ratio, a bone geometry parameter representing cortical instability, was significantly higher in the lower TSH tertile group in all three regions in women, but not in men. Our results indicated that lower TSH levels in the euthyroid range are related to lower BMD and weaker femoral structure in elderly women.Key words: TSH, euthyroidism, elderly people, bone density, bone geometry Maintaining normal thyroid function is important for achieving appropriate bone development and peak bone mass in young age, as well as for regulating the rate of bone turnover in adults [1]. It is well known that bone mineralization is reduced and that the rate of bone turnover is increased in thyrotoxicosis [1][2][3], leading to an increased risk of hip fractures [4,5]. Bauer et al. showed an association between low thyroid-stimulating hormone (TSH) levels and hip fractures in subclinical hyperthyroidism [6] and a recent meta-analysis [7] revealed increased fracture risk in cases of subclinical hyperthyroidism. Moreover, Murphy et al. reported that higher free thyroxine (fT4) levels were associated with reduced hip bone mineral density (BMD), even in

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“…Although most of the earlier research has been centered around Western countries, recent studies have started to examine the drastic urban–rural health disparity in East Asian countries as well . East Asia draws a unique picture compared with the West due to differences in pathways of urbanization.…”

Section: Introductionmentioning

confidence: 99%

Urban–rural differences in multimorbidity and associated factors in China and Korea: A population‐based survey study

Kim

Chi

2019

Geriatrics Gerontology Int

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Aim To analyze differences in multimorbidity rates and associated factors between urban and rural regions of Korea and China. Methods Data were drawn from the Gateway to Global Aging Datasets. We describe multimorbidity patterns across rural and urban settings in each of the countries. Multivariate regression was used to identify factors associated with multimorbidity in each of the countries by region. Results In China, 31% of the sample had multimorbidity, with significantly higher proportions in the cities. In Korea, 24% had multimorbidity, with higher proportions in rural areas. However, multivariate analyses showed that rurality was associated with a lower risk of multimorbidity in both countries. Also, although there was significant socioeconomic disparity regarding multimorbidity in both rural and urban China, the disparity was focused around urban areas for Korea. Conclusions Multimorbidity rates and associated socioeconomic factors varied by country and region. The concentration of socioeconomic disparities associated with multimorbidity in urban regions call to attention the vulnerability of “urban poor” in East Asia against chronic conditions. Geriatr Gerontol Int 2019; 19: 1157–1164.

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The Korean urban rural elderly cohort study: study design and protocol

Cited by 39 publications

References 16 publications

Association of metabolic syndrome and 25‐hydroxyvitamin D with cognitive impairment among elderly Koreans

Association of metabolic syndrome and 25‐hydroxyvitamin D with cognitive impairment among elderly Koreans

Low Normal TSH levels are Associated with Impaired BMD and Hip Geometry in the Elderly

Urban–rural differences in multimorbidity and associated factors in China and Korea: A population‐based survey study

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